Whether it is for recreational or medicinal purposes, Kratom has been shown to be quite beneficial and this includes the use of Kratom as a nootropic. With increased cognition, enhanced mood and reduced anxiety, there are many benefits to including this supplement in your diet.
To learn more about how you can take advantage of what Kratom as a nootropic can do for you read on!
What Is Kratom?
Kratom is a drug that can be used for both medicinal and recreational purposes. This herbal supplement comes from the leaves of a tree that grows in Southeast Asia. Kratom has been traditionally used to help alleviate pain, and although it has powerful effects on the body, it is considered non-addictive.
Kratom has also been shown to have pain-relieving properties, as well as anti-inflammatory properties, which makes it unique. Kratom has been used for centuries as a natural cure-all in South East Asia, and many Westerners are now experimenting with it.
The other uses of Kratom include
Used As A Nootropic – The anti-inflammatory properties of Kratom have been shown to help brain function, which makes this beneficial for those who use it as a nootropic. Many users report that they experience increased mental focus and clarity when using Kratom on a regular basis.
Used As A Mood Enhancer – When taken in low doses, this supplement can help to reduce anxiety and increase mood. Many users experience increased energy while taking Kratom for the first time due to its ability to relax the body and mind.
What Are The Benefits Of Taking Kratom For Nootropic Use?
Many people believe that Kratom is a natural way of speeding up pre-existing brain function, but it actually has the opposite effect in that it slows down dementia and Alzheimer's symptoms.
When used as a nootropic, Kratom can help to improve memory retention and overall cognitive function. Using Kratom in this capacity has been called "one of the best things to happen to humanity" by many users.
Studies have been conducted on the use of Kratom for medicinal purposes, such as using it to treat symptoms of depression, chronic pain and anxiety. Many people are now using Kratom as a daily supplement in order to enhance their health and lifestyle due to the numerous benefits it can provide.
Kratom is legal in many places, such as Canada and the United States, although it is illegal in some regions of the world. If you are looking to experience the benefits of Kratom for yourself, be sure that you do your research on where to buy it in your area.
How To Take Kratom For Nootropic Use?
Kratom is most commonly taken by mouth for its nootropic effects. Most people who take Kratom prefer to take it in the morning, so they can be more productive throughout the day!
When used as a nootropic, most users will experience:
Increased focus and alertness
Improved mental clarity and decreased stress levels
Reduced anxiety and depression
Improved memory retention
Enhanced mood and increased motivation
When looking to use Kratom to help with cognitive impairment, be sure to purchase from a reputable dealer who provides you with the correct information about how much to take for your desired effects.
Users who take this supplement regularly report that it is better for them when they have first eaten a small meal prior to taking the supplement. This is because it helps to absorb the ingredients of the substance more easily into the body.
Why Is Kratom Considered A Nootropic?
Kratom is considered a nootropic because it helps to improve brain function and cognitive ability, while also reducing stress and anxiety. It has been used for centuries as a natural cure-all in Southeast Asia, and it is now gaining popularity all over the world.
The compounds found in Kratom have been shown to increase focus and clarity, while also helping people to get through everyday tasks with ease. The active ingredient in Kratom, the primary alkaloid mitragynine, has been found to have powerful effects on the brain which can improve cognition.
When taking Kratom, you will feel a slight euphoric effect along with reduced anxiety. This is why many people use Kratom as a natural alternative to prescription drugs or to illegal substances such as marijuana. This supplement has been reported to help treat symptoms of depression, chronic pain and anxiety due to its mood enhancement properties.
Can You Buy Kratom Online?
When looking to buy Kratom online, there are a number of websites that offer this product for sale. Although it is legal to buy Kratom in most parts of the world, be sure to do your research before you place an order.
There are many people who have reported that they purchased Kratom from a website and had their product seized by customs. In addition, some companies have been found to be selling fake kratom products that do not contain the ingredients they advertise on their sites.
Make sure you do your research about the seller and make sure they are providing you with a legitimate product. You should also try to determine if the online shop is legal in the country you live in as Kratom is still illegal in some areas of the world.
In Summary
Although Kratom can be found in many countries, it is still considered by many to be an alternative nootropic. It can provide a number of benefits for users including increased focus, decreased anxiety and improved mood.
Kratom is legal in many countries and jurisdictions, but you should always make sure that you are buying a legitimate product. If you are looking to purchase Kratom as a nootropic supplement, make sure you have done your research about the vendor before making your purchase.
Kratom can be found online and it is often sold in powder form or as a capsule for convenience. When looking to buy Kratom, always be sure to read reviews about where you are purchasing from so that you can receive a high-quality product.
The supplement has been used for centuries as a natural alternative and is now gaining popularity all over the world.
Throughout my years of delving deep into the complex world of nootropics, I've encountered myriad compounds, each holding its unique allure and promise.
Yet, amidst the vast ocean of 'brain boosters', the Magnolia Bark Extract (MBE) stands out as a fascinating chapter in this ongoing exploration. Its whispers echo not just in today's cutting-edge labs but reverberate through the ancient corridors of traditional Chinese medicine.
For over a millennium, these very halls have revered the bark of the Magnolia tree, particularly from the species Magnolia officinalis and Magnolia obovata, as a remedy for stress, anxiety, and even digestive issues.
So, today, let's take a scientific deep-dive into the world that is Magnolia Bark and see how effective it is as a nootropic.
Magnolia Bark Extract Nootropic Summary
Source & Constituents: Magnolia Bark Extract (MBE) is derived from the barks of Magnolia officinalis and Magnolia obovata. Its primary active constituents are magnolol and honokiol.
Nootropic Benefits: MBE offers a range of cognitive enhancements including: Memory improvement, Focus and attention enhancement, anxiolytic and potential anti-depressant properties.
Mechanism of Action (MoA): MBE's cognitive benefits stem from its interactions with GABA receptors, antioxidative properties, and modulation of neurotransmitter systems.
Stacking: MBE can be combined with other nootropics like L-Theanine, Bacopa Monnieri, and Rhodiola Rosea for synergistic effects. Adjusting dosages and monitoring for interactions is crucial.
Dosage Recommendations: For cognitive benefits, a dosage ranging from 200 mg to 400 mg of standardized MBE (around 90% magnolol and honokiol) is recommended daily. Dosages can vary based on individual sensitivity and the desired effect.
Magnolia Bark Extract: Origin and Composition
Magnolia Bark Extract, sourced from the Magnolia tree, has long been a revered ingredient in Traditional Chinese Medicine (TCM). The Magnolia genus, comprising over 200 species, has its roots deep in evolutionary history, with certain species dating back nearly 100 million years.
Predominantly, Magnolia officinalis and Magnolia obovata have been the species of choice in medicinal preparations.
In TCM, the bark, referred to as "Houpu," is used not just as an isolated remedy but often in conjunction with other herbs in formulas such as "Banxia Houpu Tang," a concoction believed to address stagnation in the body and regulate the flow of 'Qi' or energy.
Chemical Composition: A Dive into Phytochemistry
At the heart of Magnolia Bark Extract's therapeutic properties lies its rich phytochemical profile. Two neolignan compounds, in particular, have piqued the interest of the scientific community:
Magnolol (MAG): A bioactive compound, magnolol is a hydroxylated biphenyl compound, possessing a range of pharmacological activities. From its notable anti-inflammatory actions to its neuroprotective capabilities, magnolol offers an extensive therapeutic profile.[1]
Honokiol: Another biphenyl compound, honokiol is often studied in tandem with magnolol due to their structural similarity. It showcases a range of pharmacological actions, from antioxidative to anxiolytic effects. Notably, honokiol can readily cross the blood-brain barrier (BBB), making it particularly relevant for neurological and cognitive applications.[2]
Furthermore, the bark extract also contains an assortment of essential oils, tannins, and flavonoids, each contributing to its multifaceted therapeutic potential.
It's worth noting that the precise composition of MBE can vary based on extraction methods, the specific species of Magnolia utilized, and environmental factors influencing the growth of the tree.
How Does Magnolia Bark Extract Work (Mechanism of Action)?
The intricate dance of molecules within Magnolia Bark Extract doesn’t merely stop at offering traditional benefits; they have, over the years, showcased a promising potential to act on cognitive and neurological pathways, aligning with the attributes of nootropics.
Interaction with GABA Receptors: The Calm Beneath the Cognitive Storm
The brain's neurotransmitters are the key players in dictating our mood, cognition, and overall neurological health. One such crucial neurotransmitter is gamma-aminobutyric acid (GABA). GABA is an inhibitory neurotransmitter, pivotal in reducing neuronal excitability and inducing relaxation.[3]
Compounds like honokiol, found in MBE, are known to interact with GABA receptors, specifically the benzodiazepine site of the GABA_A receptors.
By modulating these receptors, honokiol can promote anxiolytic effects, thus enhancing mood and reducing stress—a critical element in the pursuit of cognitive clarity.[4]
Anti-inflammatory Properties: A Guardian for the Brain
Inflammation, when unchecked, can be detrimental to brain health, often serving as a precursor to cognitive decline. Magnolol, one of MBE's primary bioactive compounds, has shown significant anti-inflammatory properties.[5]
By inhibiting the NF-kB pathway—a key player in inflammatory responses—magnolol can potentially offer neuroprotection. The relevance? A reduction in neural inflammation can enhance cognitive function, memory recall, and delay onset of neurodegenerative conditions.[6]
Neuroprotective Impact: Shielding the Brain's Fortress
Neurodegeneration is an alarming reality of our times, with conditions like Alzheimer's and Parkinson's affecting millions worldwide. MBE's honokiol has showcased potential neuroprotective effects, attributed to its antioxidative properties.
By scavenging free radicals and reducing oxidative stress, honokiol could play a role in staving off neurodegenerative conditions, thus ensuring cognitive longevity.[7]
To truly appreciate the magnitude of Magnolia Bark Extract's potential as a nootropic, we must further explore its direct cognitive benefits and effects below.
Magnolia Bark Extract's Nootropic Benefits
In the realm of cognitive enhancement, Magnolia Bark Extract offers a blend of ancient wisdom and modern scientific validation.
Its complex phytochemistry reveals a myriad of benefits, many of which have direct implications for cognitive enhancement and overall brain health.
Cognitive Enhancement: Memory Improvement
Memory, the cornerstone of cognitive function, is often vulnerable to age, stress, and external toxins. Magnolol, abundant in MBE, has shown promise in improving memory impairment.
Studies on rodents have demonstrated its potential in reversing scopolamine-induced memory deficits, thus indicating its role in cholinergic pathway modulation—a pivotal system for memory processes.[8]
Focus and Attention
In our hyper-stimulated world, maintaining focus is a formidable challenge.
MBE’s anxiolytic properties, primarily stemming from its interaction with GABA receptors, can result in reduced mental noise, thereby promoting sustained attention.
This has implications not just for day-to-day tasks but also for conditions like ADHD where focus is intrinsically compromised.
Mood Regulation: Anxiety Reduction
As previously discussed, honokiol's affinity for the GABA_A receptors, particularly the benzodiazepine site, gives MBE its potent anxiolytic effects.
With reduced anxiety, the brain can function more efficiently, process information rapidly, and improve decision-making capacities.[9]
Potential Anti-depressant Properties
Depression, often a result of neurotransmitter imbalances, can significantly hamper cognitive function.
Preliminary studies indicate that MBE might exert anti-depressant effects by modulating serotonergic and dopaminergic systems, though more research is needed to ascertain its full potential in this realm.[10]
Sleep and Relaxation: Natural Sedative Properties
Sleep is vital for cognitive rejuvenation.
Honokiol's interaction with GABA_A receptors not only confers anxiolytic effects but also has sedative properties. Improved sleep quality can subsequently lead to enhanced cognitive functions, improved memory recall, and increased focus.[11]
Neuroprotective Benefits
As discussed, the antioxidative properties of MBE's constituents, especially honokiol, play a significant role in neuroprotection.
By reducing oxidative stress, they contribute to a healthy neural environment, crucial for optimal cognitive function.
Magnolia Bark Extract is not just another natural compound; it's a symphony of molecules, each playing its part in the grand orchestra of cognitive enhancement. In the next section, we will look into its side effects and safety profile. So without further ado, let's continue.
Analysis: Magnolia Officinalis Extracts in Alzheimer's Disease
According to a study conducted on Magnolia officinalis and its impact on memory impairment and amyloidogenesis in a transgenic mouse model of Alzheimer's Disease[12] Lee et al. showcased the historical use of Magnolia bark in oriental traditional medicine. These traditional practices emphasize the bark's role in treating neurosis, anxiety, and headaches.
What this means is that the bark of the Magnolia family possesses potent bioactive components. Lee et al. identified these components as honokiol, obovatol, magnolol, and 4-O-methylhonokiol.
They found that extracts, especially 4-O-methylhonokiol, demonstrated memory-improving functions in several animal models. This discovery positions Magnolia officinalis as a potential nootropic agent.
Lee et al. further reported that both the nutritional supplement (Magnolia Extract™) and the ethanol extract of Magnolia officinalis showed promise in ameliorating memory dysfunction in Alzheimer's Disease mouse models. Notably, the ethanol extract seemed to have a more pronounced effect.
However, it's essential to note the variability in efficacy. Lee et al. suggest that the therapeutic benefits of Magnolia extracts could differ based on cultivation areas and manufacturing methods.
Magnolia Bark Extract Side Effects & Safety Profile
Magnolia Bark Extract, like any therapeutic agent, is not without its caveats.
While it boasts a broad spectrum of benefits, it's paramount to remain cognizant of its potential side effects and interactions.
Here's an overview of the most common Magnolia Bark Extract side effects:
Sedation: Due to its interaction with the GABA_A receptors, particularly via honokiol, one of the most reported side effects is sedation or drowsiness. While this can be advantageous for sleep induction, it might not be desirable during activities that demand alertness.
Allergic Reactions: Though rare, some individuals might exhibit allergic reactions to MBE, manifesting as skin rashes, itching, or even respiratory issues.
Digestive Issues: In higher doses, MBE can cause gastrointestinal disturbances such as nausea, diarrhea, or abdominal discomfort.
Interactions with Other Drugs
Given MBE's sedative properties, concurrent use with other sedatives or benzodiazepines may potentiate the sedative effects, leading to excessive drowsiness or even respiratory depression.
Anti-depressants
MBE's potential modulation of serotonergic and dopaminergic systems suggests caution when co-administered with certain antidepressants, especially SSRIs or MAOIs, to avoid the risk of serotonin syndrome.
Navigating the optimal dosage of Magnolia Bark Extract (MBE) for cognitive enhancement can be intricate. Not only does it vary based on individual sensitivity and desired effects, but also on the context in which it's taken, such as standalone use versus stacking with other nootropics.
Here's a detailed guide on how to approach MBE dosing for nootropic purposes.
Standalone MBE Dosage
When consumed solely for its nootropic benefits:
Standard Dosage: For cognitive enhancement, dosages ranging from 200 mg to 400 mg of standardized MBE (containing around 90% magnolol and honokiol) are recommended. This range can help enhance memory, focus, and mood regulation.
Sleep Aid: If leveraging its sedative properties for improved sleep, a higher end of the dosage range or slightly above, approximately 400 mg to 500 mg, taken an hour before bedtime, might be more effective.
Nootropic Stacks
Stacking refers to the practice of combining multiple nootropics to achieve synergistic benefits. When stacking MBE with other nootropics, it's important to adjust dosages and monitor for interactions.
MBE and L-Theanine: L-Theanine, commonly found in tea, is known for promoting relaxation without sedation. A combination of 200 mg MBE with 100 mg L-Theanine can offer enhanced focus and reduced anxiety.
MBE and Bacopa Monnieri: Bacopa is a revered adaptogen and nootropic herb. Stacking 200 mg MBE with 150 mg Bacopa Monnieri can potentiate memory enhancement and cognitive clarity.
MBE and Rhodiola Rosea: Rhodiola is known for combating fatigue and enhancing cognition. Combining 200 mg MBE with 200 mg Rhodiola Rosea might offer balanced energy, focus, and mood elevation.
Clinical Dosages
In clinical settings, the dosage of MBE varies depending on the condition being treated.
Stress and Anxiety: Clinical studies often employ dosages ranging from 250 mg to 500 mg daily, divided into two doses.
Depression: Clinical trials investigating MBE's antidepressant properties might use dosages of up to 500 mg daily, though results and recommendations remain preliminary.
Considerations and Caveats
Tolerance: Over time, the body might develop tolerance to MBE, necessitating an upward adjustment in dosage. It's advisable to occasionally cycle off MBE to prevent tolerance buildup.
Purity and Source: Ensure that the MBE supplement chosen is of high quality, standardized, and devoid of contaminants. The purity of magnolol and honokiol content can significantly influence dosage requirements.
Individual Sensitivity: Like all nootropics, individual sensitivity to MBE can vary. It's wise to start with a lower dose and gradually titrate upwards while monitoring for effects and side effects.
Frequently Asked Questions (FAQ)
What is Magnolia Bark Extract (MBE) and its primary constituents?
Magnolia Bark Extract (MBE) is derived from the bark of magnolia trees, primarily Magnolia officinalis and Magnolia obovata. Its primary active constituents, known for their therapeutic properties, are magnolol and honokiol.
How does MBE function as a nootropic?
MBE functions as a nootropic by enhancing memory, promoting focus, regulating mood through its anxiolytic and potential anti-depressant properties, and by aiding in sleep due to its natural sedative effects. Its interactions with GABA receptors, antioxidative properties, and modulation of neurotransmitter systems play pivotal roles in these cognitive benefits.
Can MBE be stacked with other nootropics?
Yes, MBE can be stacked with other nootropics such as L-Theanine, Bacopa Monnieri, and Rhodiola Rosea. However, when stacking, it's essential to adjust dosages and be aware of potential synergistic effects or interactions.
What is the recommended dosage of MBE for cognitive enhancement?
For cognitive enhancement, a typical recommended dosage ranges from 200 mg to 400 mg of standardized MBE (containing around 90% magnolol and honokiol) daily. However, this can vary based on individual sensitivity and desired effects.
Is it safe to take MBE every day?
Generally, MBE is considered safe for daily consumption, especially within the recommended dosage range. However, it's wise to occasionally cycle off MBE to prevent tolerance buildup and ensure its continued effectiveness.
How does MBE compare to synthetic nootropics?
MBE offers a more holistic approach to cognitive enhancement, leveraging natural compounds with multi-faceted benefits. While synthetic nootropics might have targeted and potent effects, MBE combines cognitive enhancement with additional benefits like mood regulation, antioxidative properties, and natural sedative effects, all with a generally milder side effect profile.
My Final Thoughts: Magnolia Bark Extract as a Nootropic
Navigating the intricate landscape of supplements, it's evident that not all are created equal. Magnolia Bark Extract stands out, not only as a potent herbal treatment but also as a noteworthy member within the vast family of vitamins and supplements. The broad spectrum of its uses, from managing symptoms of various conditions to potential cancer treatments, sets it apart.
Preliminary studies, especially those involving mice, have indicated significant antioxidant activity, hinting at its potential to combat oxidative stress—a common culprit behind many ailments.
Furthermore, while animal models like mice have given us valuable insights, human studies are crucial. They not only validate the findings from mice studies but also ensure the results are directly translatable to our physiology. Recent human studies have begun to corroborate many of the claims traditionally associated with this extract.
Products that harness the benefits of MBE often tout its antioxidant properties, but it's the potential liver-protective activity that piques the interest of many scientists. Given the liver's role in detoxification, any supplement or treatment that supports its function holds immense value.
However, as with all supplements and herbal products, discernment is key. While the allure of MBE is undeniable, grounded in both ancient wisdom and modern science, it's paramount to approach its consumption with an informed perspective, being aware of its multifaceted benefits and potential caveats.
Hydrafinil (9-Fluorenol) is the newest, most promising nootropic to hit the market in the last few years.
It is a stimulant that can improve focus, mood, and wakefulness without the jitters or anxiety of caffeine. It won't make you feel like you need to take a nap when the effects wear off.
If you're looking for a safer alternative to Modafinil and Adderall that doesn't have the same addictive properties, Hydrafinil may be worth looking into.
In this post we break down what you need know about Hydrafinil as well as exploring its benefits and risks in more detail.
How Does Hydrafinil Work?
The primary function of Hydrafinil is to promote wakefulness by affecting levels of the neurotransmitter adenosine, which regulates sleep and wakefulness.
It also improves attention and reaction time but without the jitters or anxiety commonly associated with stimulants like caffeine and Adderall.
These effects are similar to those of modafinil, another popular nootropic. The main difference is that Hydrafinil has not been as widely studied or is not yet fully understood by scientists – which makes it a more interesting and promising alternative.
Recent studies have shown that Hydrafinil helped improve the ability to concentrate, increase wakefulness, and even enhance mood – without the side effects of jitters or anxiety. It's more similar in this way to nootropics like Aniracetam and Pramiracetam.
In animal trials, it has been observed that Hydrafinil can protect against cognitive impairments associated with lack of sleep.
According to the FDA, Hydrafinil is a product that: "enhances wakefulness and alertness without the undesirable side effects of amphetamine-like stimulants.
Effects & Benefits of Hydrafinil
The effects of Hydrafinil are similar to Modafinil, but more powerful and longer lasting.
It takes more than a single dose to feel its effects – so start with a low dose (100 mg) and work your way up. Here's how you'll feel after taking it:
Hydrafinil has the potential to improve concentration, mood, motivation, and reaction time. It is also reported to help users lose weight by increasing their metabolism and suppressing their appetite.
Unlike caffeine, Modafinil, and other stimulants, Hydrafinil is reported to have little to no side effects.
As a result, it can be taken for long periods of time without the fear of developing an addiction. That being said, the long term effects are unknown – but probably similar to those of known nootropics like Modafinil, Aniracetam and Pramiracetam.
This makes it worth considering as an alternative if you're looking for something less potent than Modafinil but still want the advantage it provides over Adderall.
Hydrafinil's Side Effects
As mentioned, Hydrafinil has not been extensively studied or is not fully understood by science.
As a result, the long term effects of its use are unknown.
However, it has been reported to be safe and well tolerated in short term studies and many users report no side effects. Some possible side effects include headaches or gastrointestinal distress.
In addition, high dosages can lead to anxiety and insomnia. Start with a small dose (100 mg) and work up if you experience significant anxiety or insomnia after consumption.
Where to Buy Hydrafinil Online
Hydrafinil is not approved by the FDA and has not been evaluated as a drug by the agency. You can't buy it in stores or through your local pharmacy.
It is available for sale on Amazon but there have been reports of fake products that are actually just caffeine pills disguised as Hydrafinil.
My advice is to stay away from these sites because you don't know what you're getting – which can be dangerous.
What is the Difference Between Hydrafinil and Adrafinil?
Adrafinil is the parent molecule and precursor to Hydrafinil.
It must be metabolized in the body before it turns into an active form. That being said, Adrafinil is said to have a greater adverse effect on the liver compared to hydrafinil.
Cyclazodoneis aCNS stimulantwith amphetamine-like and antidepressant effects. Biohackers use it for better focus, energy & increased motivation (Cyclazodone is not meant for human consumption).
So I was doing some light research on a new potential Nootropic for a stack I'm currently trying to make and came across an interesting Smart Drug called; Cyclazodone.
One of the things that I find interesting about Cyclazodone is that the effects have been compared to those of amphetamine (but without all the negative side effects).
This, obviously, made me want to dive a little bit deeper into it - especially since people are reporting better focus, sociability, and elevated mood when they take this stimulant.
So in this article, I will take a closer look at the following;
What is Cyclazodone?
What does Cyclazodone do in the body?
What are the benefits and side effects?
Is Cyclazodone legal in your country?
What are people on Reddit saying about it?
.... So without further ado, let's jump straight to it!
What is Cyclazodone?
As I briefly mentioned in the beginning, Cyclazodone is a central nervous system stimulant with amphetamine-like effects with possessed anorexic efficacy.
The chemical name is; 2-(cyclopropylamino)-5-phenyl-1,3-oxazole-4-one. The molecular weight is 216.24 and the formula is C12H12N2O2.
Cyclazodone was first synthesized back in the '60s by an American company called; The American Cyanamid Company.
The idea behind Cyclazodone was to develop a safer CNS-stimulant to Pemoline and other similar derivatives.
Pemoline was used in the treatment of ADHD and narcolepsy but is no longer available in the US.
The FDA withdrew the approval of pemoline due to its negative side effects in children - some leading to liver failure.
Compared to Pemoline, Cyclazodone is a much safer CNS stimulant and closely related. That being said, it is only available for scientific research purposes in the US.
Cyclazodone is proven in clinical trials to be extremely effective as an energy booster in animal models withanorexigenic effects. It has unique features that set it apart from other sympathomimetic drugs with less stimulatory activity and toxicity compared to amphetamines.
What does it do in the body?
Cyclazodone is a 4-oxazolidinone stimulant that produces focus enhancing, wakefulness, and alertness effects.
When it comes to how it affects the body we have very limited data available. However, it has been shown to be extremely effective for cognitive fatigue with its nootropic properties.
That being said, it is speculated that it likely possesses a hepatotoxic, negative impact on blood pressure, and other not-known toxic effects.
We do, however, have some animal models where Cyclazodone has been shown to exhibit powerful CNS and antidepressant effects.
It also possesses anorexic efficacy and potency and the toxicity of cyclazodone is low compared to other amphetamine-like agonists.
Cyclazodone impacts the TAAR1-receptor in the brain. TAAR1 is the main regulator of serotonin, dopamine, and noradrenaline.
This leads to the release of increased concentrations of these 3 neurotransmitters in the brain which in turn enhances cognition through better concentration, mood, and energy levels.
What are the benefits and side effects?
It's worth noting that most of the benefits and side effects experienced on Cyclazodone are anecdotal.
The Subjective Effect Index is basically just a huge collection of articles designed to serve as an in-depth reference work for the subjective effects people are experiencing when taking psychoactive substances.
Here's what people are reporting in terms of the Benefits:
Stimulating - Weaker than methamphetamine, but stronger than Modafinil and caffeine.
Cognitive euphoria
Appetite suppression
Pain relief
Anxiety suppression
Empathy, affection, and sociability enhancement
Here's what people are reporting in terms of the Side Effects:
Abnormal heartbeat
Nausea - only seems to occur when higher dosages are used
Teeth grinding- but less intense compared to amphetamines
The benefits it has on cognition is the main reason why people see Cyclazodone as a potent Nootropic with the only downside being the potential side effects.
In addition, when it comes to the toxicity and long-term use of Cyclazodone, we don't have any studies (and only very limited history of human usage) which are why the exact toxic dose is still unknown.
Is it addictive?
Given the similarities that Cyclazodone and amphetamines have, a question that comes to mind is if Cyclazodone has addictive properties or not.
Whenever it comes to amphetamine-like stimulants, addiction is always a serious concern.
Compared to Pemoline, Cyclazodone doesn't seem to show any addictive properties. That being said caution is always advised like it's the case with all monoamine agents.
It's worth noting that tolerance to the effects of it only seems to develop with prolonged use. Hence, why people need larger dosages in order to feel the effects.
If you stop taking Cyclazodone, it usually takes anywhere from 4 to 7 days for the tolerance to be reduced to half.
Cognitive and physical stimulation
Cyclazodone enhances cognitive performance and is used as a study aid.
One of the possible reasons why that might be is because of how it elevates arousal, energy, pleasure, and other positive stimulatory effects through TAAR1-receptors.
In addition to increasing focus, prolonging attention span, and improving memory recall, the positively stimulating effects from Cyclazodone can also be beneficial for those that suffer from fatigue, chronic exhaustion, and other forms of mental and physical lethargy caused by certain medical conditions.
Central Nervous System Stimulants
A central nervous system stimulant like Cyclazodone is often used to treat ADHD, narcolepsy, and other sleep disorders.
It's also used as an adjunct therapy for the treatment of obesity and smoking cessation.
Cyclazodone is a potent monoamine agonist that acts as a serotonin, dopamine, and norepinephrine releasing agent.
It has been shown to be anorexic, euphoric, and cognitively stimulating.
Cyclazodone is one of the most popular central nervous system stimulants on the market.
It's worth noting that the majority of studies done on Cyclazodone were in rats and mice, not humans.
In addition, due to the lack of safety data, it should be used with caution and only by those who are experienced with similar stimulants.
Dopaminergic Stimulant
A stimulant drug that increases the activity of dopamine in the brain is considered a dopaminergic stimulant.
The typical dopaminergic central nervous system is responsible for regulating movement, motivation, pleasure, and reward.
D Amphetamine, methamphetamine, cocaine, and methylphenidate are all examples of dopaminergic stimulants.
Cyclazodone is one of the more typical dopaminergic stimulants on the market.
It's worth noting that Cyclazodone, as well as amphetamines, have a high potential for abuse and should be used with caution.
Minimal Sympathomimetic Side Effects
When we're talking about the side effects of stimulants, one thing that comes to mind is how they affect your heart.
Since Cyclazodone acts as a mild sympathomimetic, it has the potential to elevate blood pressure and heart rate by increasing norepinephrine release.
Norepinephrine is the neurotransmitter responsible for regulating both energy levels and heart rate.
Because of this, it's always important to be aware of your individual tolerance and to monitor your vitals if you are taking Cyclazodone.
In general, Cyclazodone has a lower potential for abuse and causes significantly fewer adverse effects than other stimulants like amphetamines.
That being said, it does still retain some degree of risk, and caution is advised when using it.
Due to the lack of long-term safety data on Cyclazodone, it should never be used unless you have experience with similar agents.
Antidepressant efficacy
As briefly mentioned in the beginning, Cyclazodone is also an antidepressant.
While the mechanism of action is not fully understood, it's believed that Cyclazodone increases the availability of serotonin, dopamine, and norepinephrine in the brain by blocking their reuptake.
This can lead to a variety of therapeutic benefits such as increased energy, improved mood, and decreased anxiety.
Cyclazodone is a fast-acting antidepressant that can provide relief within hours of taking it.
It's also been shown to be effective for the long-term treatment of depression.
Again, it should be noted that Cyclazodone has not been studied in humans as extensively as other antidepressants like Fluoxetine (Prozac).
Is it legal in your country?
As is the case with most Smart Drugs, Cyclazodone is in a gray area when it comes to its legality.
This means that within certain parts of the world, its regulation is in a legal gray area, and in some areas, it is a banned stimulant (we don't know if it's illegal to possess or not).
That's why some people can be charged for their possession while others won´t.
What we do know, however, is that in 2006 the World Anti-Doping Agency banned its use and put it on The Prohibited List.
From what I could find, Cyclazodone is not a controlled substance in;
Germany
Switzerland
This means that it may in some instances be considered legal. In the US it's considered a Schedule IV controlled substance.
Read Also: My Favourite Nootropics
What people on Reddit are saying about Cyclazodone
I thought it would be interesting to find 1 or 2 threads on Reddit to see what people that are actually taking Cyclazodone have to say.
I have linked to each thread so you can go over and read it for yourself.
The first thread I found is by a user called; u/-redan.
Redan starts off by saying that Cyclazodone is pretty amazing. He recently tried it and was impressed by the focus enhancement.
That being said, he did notice an anxiogenic effect.
He then goes on to say the following;
"There's a noticeable mood lift, anti-anxiety effects, combined with strong focusing enhancement effects..."
He then finishes off by saying that tolerance buildup doesn't seem to be a problem with N-Methyl-Cyclazodone and the other related compounds.
Another user called; u/Engenderling is talking about the negative side effects of N-Methyl-Cyclazodone.
The thread is a pretty detailed explanation of his Cyclazodone use.
Triacetyluridine, or TAU, is a nootropic that converts to Uridine in the body. It's proven to help alleviate the symptoms of depression by increasing dopamine levels in the brain.
If you've just recently come across Triacetyluridine you might have been wondering what exactly this relatively popular Nootropic is, what it does and if it has any potential side effects/benefits?
In this article I will take a closer look at the following topics:
What is Triacetyluridine?
What are the benefits and side effects?
What's the best dosage?
Can you stack it with other Nootropics?
What are people on Reddit saying about?
Where can you buy it?
... So without further ado, let's just jump straight to it, shall we?
What Is Triacetyluridine & How Does It Work?
As briefly mentioned in the beginning Triacetyluridine converts to Uridine in the body. Uridine is just one of the five standard nucleosides. The other four are;
Cytidine
Guanosine
Adenosine
Thymidine
When Triacetyluridine converts to Uridine Triphosphate in the body it can deliver up to 6 time as much uridine than just consuming uridine alone.
Uridine is a precursor of ribonucleic acid which supports healthy functioning of the central nervous system.
Clinically, Triacetyluridine is used in the treatment of fluorouracil overdose or toxicity. I found a study about Triacetyluridine right here where they show the efficacy in treating fluorouracil overdoses.
It's worth noting that Triacetyluridine received an FDA approval in 2015.
Triacetyluridine is found to activate the P2Y2receptors in the brain. This study shows that the P2Y2R plays a neuroprotective role during inflammation in the CNS.
The reason why people are using Triacetyluridine as a Nootrpic is because it enhances functioning in synaptic connections and improves mitochondrial functioning.
What Are The Benefits And Side Effects?
The data on potential benefits and side effects when taking Triacetyluridine is well documented.
From the studies I could find about Triacetyluridine here's what they show:
As is the case with most Nootropics, it's always a good idea to start off with a low dose to access its effects on your body/mental health.
If it's your first time trying Triacetyluridine I wouldn't recommend stacking it with other Nootropics either until you're 100% certain that it doesn't have any negative side effects.
Triacetyluridine vs Uridine Monophosphate
There isn't too much of a difference between Triacetyluridine and uridine monophosphate.
That being said Triacetyluridine is more potent and has a higher bioavailable when it comes to Uridine compared to Uridine Monophosphate.
Both supplements have the same effects and can take anywhere from 1 to 3 hours to kick in.
Utsukushii says that he just recently bought Triacetyluridine and has been getting really great results but is curious to know if stacking it with anti-depressants is a bad idea.
He then goes on to say that after taking Triacetyluridine his memory is much sharper and his mood has improved quite a bit.
He then finishes off by asking the following question:
"My question is would combining my daily anti depressants be a bad idea?"
Triacetyluridin, when converted in the body, has a direct impact on serotonin and dopamine (so would make sense why he is asking this question.)
Utsukushii doesn't get any definitive answer from people in the thead, so I'll try to answer it here:
A good rule of thumb is to NEVER combine nootropics with SSRI's unless your doctor says otherwise. Do NOT play around with your brain chemistry.
Interesting enough he is talking about Triacetyluridine and smoking.
He starts off by saying how he never though that he would quit smoking. He goes on to say the following:
"I was ruining my lungs and I was having so much trouble breathing. I had tried everything."
He then came across Triacetyluridine.
He took 25mg/day every morning and noticed how he could bear working with only 1 cigarette break.
U/srubek tried vaping but compared to Triacetyluridine (TAU), TAU never left him wanting cigarettes.
The then states the following:
"I was amazed. I still am, tbh. 1.5 years cigarette-free, and healthy af"
He then goes on to say that people from work have made comments about his skin quality (asking what he did).
"I appeared shiny, smooth, clear, healthy."
The thread is extremely detailed so if you're thinking about quitting smoking I can highly recommend reading the entire thread here (U/srubek is going into much more details).
Where Can I Buy Triacetyluridine?
You can find Triacetyluridine on most Nootropic websites. TAU is sold in both powder form and capsules.
I only buy from one vendor which is called; NootropicsDepot. The reason being they lab test their products to ensure high quality and purity.
They also have a lot of reviews from verified buyers which is always a good thing.
Primavie Shilajit is a natural occurring compound found in the Himalayas. Shilajit is known to boost energy and testosterone levels.
Hey Guys!
If you've been in the Nootropic-space for some time you should know by now what Primavie Shilajit is.
If you don't, or you just simply want to find out more information about it, then this article is for you.
The information I share in this article will be based on my own personal experience and what the science says.
I will also try to see if I can find some anecdotes from people on Reddit to give a more nuanced picture of the benefits and side-effects that people are experiencing when taking Primavie.
Here are some of the topics I will be covering in today's article:
What is Primavie Shilajit?
How does it work?
How do you take it and how much should you take?
What are the benefits and side-effects?
What are people on Reddit saying about it?
Where can I buy it?
...... So without further ado, let's just jump straight to it!
What Is Primavie Shilajit & How Does It Work?
Primavie Shilajit is traditionally considered to be a divine medicine. It has been used for centuries in ancient cultures as a herbal for healing and vitality.
Due to its profound adaptogenic health benefits, and anti-aging powers, we have discovered (just recently) by combining this ancient knowledge with modern science that it derives its benefits by enhancing the upregulation of the collagen genes in our skeletal muscles.
This is why we can see that consumption Primavie Shilajit improves blood flow to the skin, testosterone levels in men, increases energy levels as well as supporting bone health.
I will talk more about the benefits later on in this article. But for now, let's just continue with some more background information.
Shilajit is a naturally occurring resin. A resin is just a solid substance from a plant.
It is found high in the Himalayan mountains as an organic substance containing a mixture of fulvic acid, minerals and other organic minerals.
It is then extracted and turned into an extraordinary Himalayan superfood and sold as Primavie Shilajit.
As I briefly stated above, Primavie Shilajit contains A LOT of different organic minerals. All of these minerals play a crucial role when it comes to improving our overall health.
Interesting enough it also has a profound effect on testosterone levels which I find fascinating.
I came across a randomised, double-blind, placebo-controlled clinical study where they measured the effects that Primavie Shilajit has on testosterone levels.
In the experiment they used purified Shilajit in healthy volunteers of age between 45 and 55 years.
What they found was that a treatment with Shilajit for 90 days in total, revealed that it has a significant effect on testosterone levels.
It increased total testosterone, free testosterone and dehydroepiandrosterone (DHEAS) compared with placebo.
As I have already alluded to earlier Primavie Shilajit has a lot of benefits. I will list the benefits right below which will be a combination of what I could find in the literature as well as from my own experience.
The most commonly reported benefits are:
Improved sleep quality
Increased testosterone levels
Improved energy levels
Improved mood
Enhanced cognition (better focus, more alertness and mental energy)
In terms of side-effects I couldn't really find any conclusive evidence/anecdotes that found anything noteworthy.
My Personal Experience With Primavie Shilajit
I can definitely attest to the cognitive benefits that people are reporting experiencing when taking Primavie Shilajit.
Although it's only been 9 days one of the things that I noticed almost instantly (could be placebo though?) is the effect it has on my mood.
I think it's safe to say that I'm a person that tends to be on the more 'neurotic side' of the spectrum (dealing with social anxiety etc.).
What I have found is not that Primavie Shilajit has a 'calming effect' on me per se but it gives me the mental and physical energy to get stuff done.
It's hard to describe but I feel like it gives me a subtle drive and groundedness to make things happen as well as an overall sense of well-being which especially has helped me out at social events.
The benefits I experience taking Primavie Shiljit is very similar to the benefits I get on Ashwagandha.
So to summarize, here's the benefits I personally have experienced taking Primavie Shiljit
I have way more mental energy (I can think clearly and my memory has improved)
I feel a subtle 'groundedness' that has been EXTREMELY useful in social situations (dealing with social anxiety)
I have noticed positive improvements in terms of mental- and physical energy (I want to make things happen)
I feel less fatigued at the end of the day
In terms of fatigue, one thing that I have noticed is that I'm not mentally exhausted in the evening anymore.
This is the benefit that actually has been the most noticable.
I work a 9-5 job and will usually be exhausted by the time I get home. To put this into perspective I usually try to write an article for Nootropicology early in the morning because I know writing in the evening is a no-go for me.
After taking Primavie Shiljit I have actually changed my schedule. I now only write in the evening which is a HUGE deal for me.
Keep in mind I have only used it for 9 days so the benefits I have experienced thus far could just be a placebo effect, but whocares if it works, right :-)?!
Primavie Shilajit And Weight Training
Since I don't really work out anymore I can't give you guys an in-depth insight to the effects it has on weight training.
That being said, I did find a couple of YouTube videos with people who are doing weight training and using Primavie Shilajit.
The first video I could find is from a guy named; Tiger Fitness. He almost has 400k subscribers.
Here's what he's saying about Primavie Shilajit its effects on training, testosterone and libido:
Another guy called; The Nootropic Republic is sharing his own experience with Primavie Shilajit here:
The Nootropic Republic is basically saying how great of an impact Primavie has had on his exercise performance.
He then goes on to say that it has been shown to help you lift more in the gym. Whether you want to improve your bench, squat, deadlift etc. Primavie can have a beneficial effect on those goals.
He then goes on to say that he personally can notice a difference in his lift as well as feeling more powerful or 'dynamic' as he puts it.
He finishes off by saying that his recovery in the gym is shorter and how Primavie has helped improve his muscle density and muscle strength.
I would imagine that Primavie could help with the pump as well since it's proven to increase blood flow to the muscle (one of you guys would have to test that out for yourself and report back to me).
A question I often see on forums is; What does Primavie Shilajit taste like? First off, it's important to note that there are different grades of this compound.
Typically the darker powders are stronger in flavor with a somewhat 'earthy' bitter taste.
The powder I bought doesn't have that strong of a taste. That being said it does taste a little weird, but it's something you get used to.
This might not sound appealing for most of you guys but whocares, it's a 'superfood' so I just chug it down.
The way you take Primavie Shilajit is by blending it into hot drinks, shake or just put it in a glass of water and chug it down.
That being said, Primavie Shilajit is traditionally consumed with raw milk in parts of North India, Pakistan, and Nepal.
For those of you who don't enjoy the taste of the powder Primavie Shilajit can be consumed as capsules as well.
What's The Right Dosage?
As is the case with most Nootropics and supplements the dose you should take really comes down to your personal goals, body weight and tolerance.
That being said from the information I could find online prior to buying it, a regular dose is 250 mg once a day which is equivalent to 1 capsule if you buy Primavie Shilajit from NootropicsDepot.
I personally started out with 125mg (half a capsule) to measure any potential side-effects. I didn't notice anything and gradually increased my daily intake to 2 capsules (500mg) which seems to be the sweet-spot for me.
It's impossible to overdose on this mineral powder and it is known to be safe, to consume over a long period of time.
It should, however, be avoided when pregnant and it's always a good idea to get the advice of your healthcare provider when taking any supplement.
Where Can I Buy It?
Since Primavie Shilajit is a natural compound you can find it pretty much anywhere on the internet.
It comes in both powder form and capsules.
I only have experience buying Nootropics from Science.bio. The reason being they lab test their products to ensure that each batch is high in quality and purity.
I live in Europe and it took 9 business days to arrive using the standard shipping method.
What Do People On Reddit Say About Primavie Shilajit?
I came across a couple of interesting threads on Reddit. One in particular caught my eyes.
I thought it would be a good idea for me to share everything here. Hopefully you guys, like me, get some value out of this.
He starts off his thead by stating that Primavie Shilajit is NOT some snake oil.
Bobz216 then goes into his own personal experience with the mineral. The first thing he has noticed after taking Primavie Shilajit for a couple of days is the boost in cognition. He says:
"I have been taking shilajit for a couple days now, and notice an immense boost in my cognition and energy.."
Bobz216 has bought his Primavie Shilajit from NootropicsDepot which is purified (it doesn't put him in risk of heavy-metal poisening).
Interesting enough he also talks briefly about its altering effects;
"This substance exhibits strong subjective feelings and a sense of altered consciousness..."
Like myself, Bobz216 has noticed his lethargy is reduced greatly and energy is increased. He also states that the energy he gets from Primavie Shilajit feels 'natural' unlike caffeine etc.
Bobz216 also notices the effects on his libido or as he puts it:
"My sex drive, which has been an issue for me in the past thanks to PSSD from Lexapro, seems to have increased greatly as well. "
He then goes on to say that he feels more 'in the moment' when he has sex as well as lasting longer.
Bobz216 states that he has OCD and how effective Primavie Shilajit has been on his logical thinking. He finds his inner voice to be 'clearer' and is able to differentiate between obsessive and rational thoughts.
He finishes off by saying that he bought Primavie Shilajit not under the impression that it was going to exhibit any psychoactive effects (he bought it for the purported sexual effects) but was pleasantly surprised by the mental benefits he experienced on it.
In Conclusion
Primavie Shilajit is a natural occurring herb found in the Himalayas.
Shilajit is known to boost energy and testosterone levels as well as libido.
People are reporting increased energy levels, better focus, more clearity and vitality consuming it with no side effects.
From my own experience I can attest to the fact that Primavie Shilajit has had a profound effect on my mental health.
I have experienced more mental- and physical energy. A subtle groundedness that has been extremely beneficial in social situations.
Primavie Shilajit is legal and can be bought from most Nootropic Vendors online.
