Friday 31 May 2024

8 Most Powerful Nootropics In 2024

the-most-powerful-nootropics

In this article, I'll look at the 8 most powerful nootropics. I'll also cover the potential risks and side effects you may run into and the benefits you can expect.

Nootropics come in all shapes and sizes, and it can be challenging to determine which one is best for you. The market is full of options, and it can sometimes be difficult to know which will work best.

Today I'll be discussing the 8 most powerful nootropics available in 2023. These have a proven track record and are backed by research, so you can be sure they'll provide the results you're looking for.

Let's see what Science says about these 8 brain boosters, shall we?

The most powerful nootropics, according to scientific evidence, are:

  • Nooceptin
  • Modafinil
  • Armodafinil
  • Phenibut
  • Piracetam
  • Noopept
  • L-Theanine + Caffeine
  • CDP-Choline

1. Nooceptin

Nooceptin (FDG-117) is a powerful nootropic blend scientifically developed to help unlock your full mental capacity. Its amazing formula contains 7 carefully selected nootropic ingredients designed to provide energy and clarity of mind.

These ingredients work synergistically to improve focus and performance, allowing you to maximize your potential.

Nooceptin contains the following nootropic ingredients:

  1. Citicoline (as CDP Choline aka cytidine 5'-phosphocholine, sodium)
  2. Rhodiola Rosea 150 mg Extract (3% rosavins & 1% salidroside) 
  3. Bacopa Monnieri Extract - 150 mg (40% bacosides)
  4. L-Theanine (L-γ-glutamylethylamide) - 200 mg 
  5. Ginkgo Biloba Extract - 100 mg (24% ginkgo flavone glycosides & 6% terpene lactones) 
  6. Lion's Mane Mushroom Extract - 400 mg (30% polysaccharides)
  7. Panax Ginseng Extract - 200 mg

With the synergistic combination of Ginkgo Biloba, L-Theanine, Citicoline, and Rhodiola Rosea, you can unleash peak performance in all aspects of your life.

This powerful stack not only boosts mental alertness but also offers protection from stress, increasing concentration capabilities and improving cognitive abilities for maximum focus.

Rhodiola Rosea, in particular, has been shown to increase cognitive function, memory, attention span, and reduce stress.[1]

Nooceptin Pros

  • An all-natural blend containing 7 nootropics
  • Increases mental alertness and cognitive abilities
  • Protects from stress Improves memory, attention span, and focus
  • You don't need a prescription from your doctor

Nooceptin Cons

  • Shipping times can take up to 2 weeks

Nooceptin in Summary

Nooceptin is a nootropic blend, meaning it contains several different ingredients that have been scientifically tested and proven to help increase your focus, mental alertness, and cognitive abilities. This powerful combination of 7 nootropics will give you the energy and clarity of mind to reach peak performance in all aspects of your life.

2. Modafinil

Modafinil (Provigil) is a eugeroic (wakefulness-promoting) nootropic used to treat excessive sleepiness caused by narcolepsy, shift work disorder, and obstructive sleep apnea.

It is one of the most popular nootropics on the market as it has a long history of clinical use for treating excessive daytime fatigue in patients with narcolepsy.[2]

Modafinil has been found to remarkably affect the human brain, boosting dopamine levels far beyond what is considered clinically relevant. Remarkably, it does this by occupying and blocking the same binding site for cocaine in the striatum - an important area associated with reward motivation.[3]

While the precise mechanism of Modafinil is yet to be elucidated, Volkow, Nora D et al. suggest that it may act on certain areas in our brain related to hypocretin, histamine, epinephrine, γ-aminobutyric acid (GABA), and glutamate.

Modafinil Pros

  • Increases wakefulness and alertness
  • Improves cognitive abilities and focus
  • Reduces fatigue
  • One of the most powerful nootropics currently on the market

Modafinil Cons

  • You need a prescription from your doctor

Modafinil in Summary

Considered one of the most powerful nootropics currently on the market, Modafinil is a wakefulness-promoting drug widely used to treat narcolepsy and shift work disorders. It is known for increasing alertness and cognitive abilities and reducing fatigue. While it does require a prescription from your doctor, Modafinil can be a great choice for those looking to take their cognitive performance to the next level.

3. Armodafinil

Armodafinil (Nuvigil) is a newer version of Modafinil and shares many of the same benefits. It is slightly more powerful than Modafinil and has been found to have longer-lasting effects.

Armodafinil is the longer-acting isomer of Modafinil and is used to treat obstructive sleep apnea, narcolepsy, and shift work disorder. Compared with Modafinil, Armodafinil maintains higher plasma concentrations later in the day in healthy subjects.[4]

If you're looking for a powerful nootropic lasting up to 15 hours, then Armodafinil should be your go-to choice.

Armodafinil Pros

  • Longer lasting effects than Modafinil
  • Increases wakefulness and alertness
  • Improves cognitive abilities and focus
  • Reduces fatigue

Armodafinil Cons

  • Requires a prescription from your doctor

Armodafinil in Summary

Armodafinil is the newer and more powerful version of Modafinil. It maintains higher plasma concentrations later in the day and lasts up to 15 hours. Like its predecessor, Armodafinil increases wakefulness, alertness, cognitive abilities, and focus while reducing fatigue.

4. Phenibut

Phenibut (beta-phenyl-gamma-aminobutyric acid HCl) is an amazing neuropsychotropic drug that was discovered and first used in Russia during the 1960s.

Not only does it have anxiolytic properties, but it also increases cognition by mimicking GABA receptors of both types A and B.[5] Phenibut is considered a tranquilizer and nootropic drug and is widely used to ease anxiety, improve sleep quality, and reduce stress.

More recently, Phenibut has gained popularity among people with social anxiety and is often used to promote feelings of well-being. The downside of Phenibut is that it can be addictive and cause withdrawals in people who take it for too long.

That said, Phenibut is one of the most powerful nootropics on the market and can be a great choice for those looking to reduce anxiety and improve cognition.

Phenibut Pros

  • Anxiolytic properties
  • Improves sleep quality and cognitive abilities
  • Reduces stress levels
  • Promotes feelings of well-being

Phenibut Cons

  • It can be addictive with overuse
  • Tolerance can develop quickly with regular use

Phenibut in Summary

Phenibut is an amazing neuropsychotropic drug that has gained popularity among people with social anxiety. It is a tranquilizer and nootropic drug used to ease anxiety, improve sleep quality, reduce stress levels, and promote feelings of well-being. Despite its many benefits, Phenibut can be addictive and cause withdrawal when taken for too long. Therefore, using this nootropic wisely and taking breaks during long-term use is important.

5. Piracetam

Piracetam (2-oxo-1-pyrrolidine-acetamide) is one of the most widely used nootropic drugs and holds tremendous promise for optimizing brain function.

It's a cyclic derivative of gamma-aminobutyric acid, which increases learning abilities, memory retention capacity, and overall metabolism in cerebral activity.

Studies have demonstrated that Piracetam can modify the physical attributes of plasma membranes by making them more liquid and safeguarding cells from hypoxia (low levels of oxygen in body tissues).[6]

Piracetam is a versatile nootropic compound possessing antithrombotic, neuroprotective, and rheological properties. Restoring membrane fluidity through its interaction with phospholipids in the membranes of cells is highly efficacious for various disorders, from dementia and vertigo to myoclonus and stroke.

Piracetam Pros

  • Improves learning abilities and memory retention capacity
  • Reduces hypoxia
  • Modifies physical attributes of plasma membranes
  • Antithrombotic, neuroprotective, and rheological properties

Piracetam Cons

  • It can be difficult to obtain because it is unregulated in many countries

Piracetam in Summary

Piracetam is one of the most widely used nootropics and holds tremendous promise for optimizing brain function. It increases learning abilities, memory retention capacity, and overall metabolism in cerebral activity.

6. Noopept

Noopept (GVS-111), a proline-containing dipeptide, has both nootropic and neuroprotective properties. This remarkable compound can stimulate inhibitory interneurons in the hippocampus stratum radiatum, which is the area of the brain responsible for learning and memory.[7]

Noopept has shown remarkable potential in protecting the brain from various damaging forces, such as ionic disruption, excessive excitation of nerve cells, free radical formation, and pro-inflammatory cytokine accumulation.[8]

Its ability to prevent neurotrophin deficits - which are common features of neurological diseases like Alzheimer's Disease (AD) – has led researchers to investigate its neuroprotective action in various studies.

Noopept is a powerful ally in the fight against cognitive decline and numerous neurological diseases.

Noopept Pros

  • Stimulates inhibitory interneurons in the hippocampus stratum radiatum
  • Protects the brain from various damaging forces
  • Prevents neurotrophin deficits common to neurological diseases like Alzheimer’s Disease

Noopept Cons

  • More long-term studies are needed to understand the risks of long-term use

Noopept in Summary

Noopept is a proline-containing dipeptide with nootropic and neuroprotective properties. It can stimulate inhibitory interneurons in the hippocampus stratum radiatum, a brain area responsible for learning and memory. It has demonstrated the potential to protect the brain from various damaging forces.

7. L-Theanine + Caffeine

L-Theanine and Caffeine are two natural nootropic ingredients that, on their own, have powerful cognitive benefits. But when combined, they form a powerful duo that can improve mental performance, focus, alertness, energy levels and promote relaxation and well-being.

L-Theanine is an amino acid found in green tea that has been shown to reduce stress, relaxation, anxiety, and sleep quality.[9] It can also reduce the stimulating effects of caffeine, improving its overall efficacy.

Caffeine is a powerful stimulant that increases alertness and concentration; it has been used for centuries to improve cognitive performance. Caffeine also enhances memory, mood, reaction time, and decision-making skills.

One study aimed to compare the effects of 50 mg of caffeine with and without 100 mg of L-theanine on cognition and mood in healthy volunteers.[10]

The cognitive abilities tested included word recognition, rapid visual information processing, critical flicker fusion threshold, and attention switching. The mood was also assessed. 27 participants were tested at baseline and again 60 min and 90 min after each treatment (separated by a 7-day washout).

The results showed that caffeine improved subjective alertness at the 60 min mark and accuracy on the attention-switching task at 90 min.

Furthermore, the combination of L-theanine and caffeine improved both speed and accuracy of performance for the attention-switching task at 60 min. It also reduced susceptibility to distracting information in the memory task at both 60 min and 90 min marks.

This research indicates that when L-theanine and caffeine are combined, cognitive performance is heightened significantly, while distraction during memory tasks becomes a thing of the past.

These outcomes mirror other studies, demonstrating that combining these two nootropic ingredients can be highly advantageous for excelling in activities requiring intense mental focus.

L-Theanine + Caffeine Pros

  • An all-natural nootropic stack widely available in stores
  • Improves mental performance, focus, alertness, and energy levels
  • Reduces stress, relaxation, anxiety, and sleep quality

L-Theanine + Caffeine Cons

  • L-Theanine can cause drowsiness in high dosages

L-Theanine + Caffeine in Summary

L-Theanine and caffeine are two natural nootropics that have powerful cognitive benefits when used together. They can heighten mental performance, focus, alertness, and energy levels while reducing stress levels and promoting relaxation.

8. CDP-Choline

CDP-choline (cytidine-5'-diphosphocholine) is a phospholipid clinically proven to aid in treating cognitive disorders. It works by restoring and preserving brain cell membranes, thus allowing for improved mental health and performance.

It is a nootropic supplement that has been used to optimize cognitive performance by enhancing neurotransmission in the brain. It works by increasing the synthesis of acetylcholine (ACh), which is essential for many cognitive functions such as memory and learning.

CDP-choline acts on the Alpha7 nicotinic receptor, a type of receptor found in neurons throughout the brain, enabling improved communication between neurons. This can lead to faster and more efficient processing of information in the brain.[11]

According to Knott, Verner et al., CDP-choline can modulate brain waves and neural oscillations associated with cognitive processes through EEG (electroencephalography) recordings.

The EEG recordings have revealed that CDP-choline can induce dose-dependent changes in delta and alpha oscillations in healthy volunteers given both low (500 mg) and moderate (1000 mg) doses of CDP-choline when compared to placebo.

This effect is thought to be driven by increased cholinergic transmission resulting from increased acetylcholine synthesis with CDP-choline administration. 

This makes CDP-choline a powerful nootropic if you're looking to optimize brain function and cognition.

CDP-Choline Pros

  • Can help treat cognitive disorders
  • Enhances neurotransmission in the brain
  • Increases acetylcholine synthesis for improved cognition

CDP-Choline Cons

  • Not as potent as other nootropics like Nooceptin and Modafinil

CDP-Choline in Summary

CDP-choline is a powerful nootropic compound clinically proven to aid cognition and brain function. It works by increasing acetylcholine synthesis, an essential neurotransmitter for many cognitive functions such as memory and learning.

What Are The Most Powerful Nootropics?

the most powerful nootropics

According to my market research, clinical trials, and user reviews, the 8 most powerful nootropics are:

  1. Nooceptin
  2. Modafinil
  3. Armodafinil
  4. Phenibut
  5. Piracetam
  6. Noopept
  7. L-Theanine + Caffeine
  8. CDP-Choline

My list contains a mix of natural and pharmaceutical compounds that have been tested for their cognitive enhancement capabilities.

All of these nootropics can be used to improve mental performance, focus, alertness, and energy levels while reducing stress levels and promoting relaxation.

If you're brand spanking new to the world of nootropic supplements, I highly recommend looking into nootropic blends like Nooceptin. With Nooceptin you get 7 all-natural nootropic ingredients that have been clinically tested and proven effective for cognitive enhancement.

It's a great starting point for anyone looking to experience the power of nootropics without having to take multiple supplements.

How to Choose The Most Powerful Nootropics?

When choosing which nootropic to take, it’s important to do your research and consider the pros and cons of each. Consider your goals for using a nootropic, as different types will be better suited for certain tasks.

Also, read up on reviews from other people who have used the product in question and the manufacturer’s instructions on how to safely use the nootropic. Your health should always be a priority, so ensure you read up on potential side effects before taking a new supplement.

There's a big difference between synthetic and natural nootropics, and it's important to be aware of the pros and cons of each type. Synthetics tend to be more effective but can also have more side effects than natural nootropics.

What Are the Benefits of The Most Powerful Nootropics?

The benefits of using some of the most powerful nootropics on the market are numerous. They range from improved mental performance, focus, and alertness to reduced stress levels and cognitive enhancement.

Synthetic nootropics such as Phenibut and Modafinil are some of the best for improving your productivity while providing you with long-term benefits such as better memory formation, learning speed, and increased relaxation.

Natural nootropics such as Nooceptin and L-Theanine + Caffeine are some of the healthiest alternatives as they are derived from natural sources and lack the harsh side effects often associated with synthetics.

When you use nootropic blends like Nooceptin you get the added bonus of having multiple nootropic ingredients working synergistically, meaning that they can provide greater benefits than a single nootropic.

What Are the Side Effects of The Most Powerful Nootropics?

The side effects come from various factors, including the type of nootropic you’re taking, your body chemistry, and pre-existing medical conditions.

That being said, some common side effects associated with the most powerful nootropics include headaches, nausea, and dizziness. Modafinil and Phenibut can cause more serious side effects. Phenibut can cause severe withdrawals when used in high doses, so it’s important to discuss with your doctor how much is safe for you.

Modafinil has been associated with a rare skin condition called Stevens-Johnson Syndrome. It’s important to pay attention to any changes in your skin after taking Modafinil and discuss them with your doctor.

Do The Most Powerful Nootropics Really Work?

So do these powerful nootropics on my list really work? The answer is yes.

These nootropics have been clinically tested and proven to provide cognitive enhancement, focus, alertness, improved mental performance, and energy levels while reducing stress and promoting relaxation.

Synthetics may be more effective, but they come with the risk of possible side effects, so it’s important to discuss with your doctor which type of nootropic would be best for you.

Natural nootropics are safer and have fewer risks, so they’re great for beginners or people who are more sensitive to the effects of synthetic nootropics.

Final Thoughts

So what do we know about the most powerful nootropics?

We know they can help improve mental performance, focus, alertness, and cognitive function while reducing stress levels. Some synthetic nootropics can be more effective than natural nootropics but come with the risk of side effects.

We also know that nootropic blends like Nooceptin can provide greater benefits than a single nootropic on its own. This is because different ingredients work together synergistically, meaning that they can provide more efficient and greater results.

So if you're looking for a powerful ally to help you stay sharp and focused, the most powerful nootropics are definitely worth considering!

References
  1. Ivanova Stojcheva, Emilija, and José Carlos Quintela. “The Effectiveness of Rhodiola rosea L. Preparations in Alleviating Various Aspects of Life-Stress Symptoms and Stress-Induced Conditions-Encouraging Clinical Evidence.” Molecules (Basel, Switzerland) vol. 27,12 3902. 17 Jun. 2022, doi:10.3390/molecules27123902
  2. da Silva Behrens, Nilce Sanny Costa et al. “Experience with the use of modafinil in the treatment of narcolepsy in a outpatient facility specialized in diurnal excessive sleepiness in São Paulo.” Sleep science (Sao Paulo, Brazil) vol. 7,1 (2014): 65-8. doi:10.1016/j.slsci.2014.07.017
  3. Volkow, Nora D et al. “Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications.” JAMA vol. 301,11 (2009): 1148-54. doi:10.1001/jama.2009.351
  4. Darwish, Mona et al. “Armodafinil and modafinil have substantially different pharmacokinetic profiles despite having the same terminal half-lives: analysis of data from three randomized, single-dose, pharmacokinetic studies.” Clinical drug investigation vol. 29,9 (2009): 613-23. doi:10.2165/11315280-000000000-00000
  5. Lapin, I. “Phenibut (beta-phenyl-GABA): a tranquilizer and nootropic drug.” CNS drug reviews vol. 7,4 (2001): 471-81. doi:10.1111/j.1527-3458.2001.tb00211.x
  6. Winnicka, Katarzyna et al. “Piracetam--an old drug with novel properties?.” Acta poloniae pharmaceutica vol. 62,5 (2005): 405-9.
  7. Kondratenko, Rodion V et al. “Effect of nootropic dipeptide noopept on CA1 pyramidal neurons involves α7AChRs on interneurons in hippocampal slices from rat.” Neuroscience letters vol. 790 (2022): 136898. doi:10.1016/j.neulet.2022.136898
  8. Ostrovskaya, Rita U et al. “Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation.” Journal of biomedical science vol. 21,1 74. 6 Aug. 2014, doi:10.1186/s12929-014-0074-2
  9. Hidese, Shinsuke et al. “Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.” Nutrients vol. 11,10 2362. 3 Oct. 2019, doi:10.3390/nu11102362
  10. Owen, Gail N et al. “The combined effects of L-theanine and caffeine on cognitive performance and mood.” Nutritional neuroscience vol. 11,4 (2008): 193-8. doi:10.1179/147683008X301513
  11. Knott, Verner et al. “Effects of acute CDP-choline treatment on resting state brain oscillations in healthy volunteers.” Neuroscience letters vol. 591 (2015): 121-125. doi:10.1016/j.neulet.2015.02.032


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Wednesday 29 May 2024

Functional Yeast Extract: The Overlooked Nootropic

functional_yeast_extract
functional_yeast_extract

It's been a while since we have seen any new nootropic developments.

This is what makes the recent discovery of functional yeast extract so exciting.

In this article, I'm going to introduce you to a new type of nootropic that has been gaining popularity recently among students and professionals alike - functional yeast extract.

We will look at what functional yeast extract is, its potential benefits, and how to take it. So without further ado, let's get started!

What is Functional Yeast Extract?

The term "yeast extract" refers to yeast extracts produced by removing the cell walls from the yeast cells and extracting the cell contents.

Yeast extract is commonly used in foods as a flavor enhancer and food additive.

Yeast extract is a liquid or powdery form of yeast. Yeast extract can be found in a variety of foods including crackers, gravy, and frozen meals.

Saccharomyces cerevisiae is a strain of yeast that has been used in the production of bread, beer, and winemaking for thousands of years. It was discovered by dipping grape skins into wine.

Yeast extracts are high in B vitamins, especially B1-3, B6, and B12.

B Vitamins have been implicated in the breakdown of carbohydrates, proteins, and fats into usable energy. Vitamin B12 has been observed to improve mood in several studies.

During fermentation, yeasts produce beta-glucans.

Beta-glucans are sugars that may be found in the cell walls of yeasts, fungus, bacteria, algae, and other plants.

Beta-glucans have been used for health benefits on occasion.

The primary advantage of yeast extract is the presence of beta-glucans.

What are Beta Glucans?

As briefly mentioned above, beta-glucans are sugars that may be found in the cell walls of yeasts, fungus, bacteria, algae, and other plants.

Beta-glucan is a soluble fiber known as "yeast polysaccharide."

Yeast extract contains up to 50% beta-glucans by weight! That's an incredible amount.

In fact, yeast extract contains more beta-glucans than other dietary sources of soluble fiber.

Beta-glucan is a type of polysaccharide that has been associated with the maintenance and improvement of overall immune function in humans, but it can benefit your brain as well!

When you take it as a Nootropic supplement, the beta-glucans in yeast extract may enhance cognition by stimulating neuron growth and protecting neurons.

What are the benefits of yeast extract?

The benefits of yeast extract are often attributed to the presence of beta-glucans.

Beta-glucan is known for its anti-viral and anti-bacterial properties, but it also has a number of cognitive benefits as well!

In addition to improving your immune system and supporting cardiovascular health, beta-glucan may enhance cognition by stimulating neuron growth and protecting neurons in the brain.

The abundance of beta-glucans in yeast extract may also enhance overall cognitive function, improving memory and focus in healthy individuals.

How do I take yeast extract?

While you can find yeast extracts in a variety of foods, the best way to obtain them is through supplementation.

If you are interested in taking functional yeast extract as a supplement, make sure that it contains at least 50% beta-glucans by weight!

This ensures that your dosage will be potent and effective.

If you'd like to try functional yeast extract as a nootropic, I recommend taking between 250mg-500mg daily with food!

This is the standard dose used in studies on this supplement so far.

Remember that all supplements should be taken responsibly and if you have any questions about how to take functional yeast extract as a supplement, consult your doctor.

What foods should I avoid?

If you are taking yeast extract as a supplement, make sure that you do not eat any food containing yeast!

Yeast is naturally high in beta-glucans and it may cancel out the effects of supplementation.

Yeast extract supplements typically come with this warning, but keep an eye on your diet to make sure you don't eat any food with yeast in it!

What else should I know?

There is not much known about the long-term effects of supplementation on human subjects, but there are some concerns that have been raised.

Supplements containing beta-glucans may increase blood sugar levels and interact with diabetes medications or insulin in some cases.

You should also be aware that yeast extract may affect how other medications and supplements are metabolized.

Can I stack Functional Yeast with other Nootropics?

As long as you avoid food that contains yeast, then stacking functional yeast extract with other nootropics is perfectly fine!

Functional yeast extract can provide a variety of cognitive benefits and it may enhance the effects of other supplements.

You should also be aware that there are some reports indicating beta-glucans in functional yeasts could interact with MAO-inhibitors and thyroid medications.

The effects of yeast extract may also be enhanced by stacking it with other nootropic supplements such as L-theanine and Lion's mane mushroom.

What are the side effects of yeast extract?

While there is not much known about the safety and long-term efficacy of supplementation, some studies have indicated that beta-glucans may interact with certain medications.

In theory, yeast extracts containing high concentrations of functional beta-glucan could increase blood sugar levels or alter insulin regulation in diabetics.

Additionally, yeast extract supplements could increase the risk of bleeding when taken in conjunction with blood thinners like warfarin or aspirin.

However, there is not much known about these interactions at this time!

It's still recommended that anyone taking medications seek the advice of their doctor before beginning supplementation.

So how do I get my hands on Functional Yeast Extract?

If you are interested in trying functional yeast extract as a nootropic, then your best bet is to purchase it online!

While this supplement isn't available at most brick and mortar stores yet, you can find it online (Nootropicsdepot for instance.)

If you are interested in trying this nootropic, then make sure to purchase it from reputable suppliers that clearly list the number of beta-glucans present in each dose.

Keep an eye out for supplements containing high concentrations of beta-glucans by weight to ensure you are getting a potent dosage!

Conclusion

In summary, functional yeast extract provides a variety of cognitive benefits and it is particularly effective at improving memory!

It may also enhance the effects of other nootropics or supplements you take to further boost your brainpower.

However, there are some concerns about its long-term efficacy as well as interactions with medications that should be considered before supplementation.

It's also important to note that functional yeast extract is not available in local stores, so you'll need to purchase it online if you want this nootropic!

Make sure the supplier lists the number of beta-glucans present in each dose and always consult with your doctor before starting supplementation.



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Tuesday 28 May 2024

Glutathione: Is It Worth Trying as a Nootropic?

nootropics_that_work
nootropics_that_work

In recent years, the use of Glutathione Powder as a nootropic supplement has been on the rise.

It is sold by companies such as LifeExtension and NootropicsDepot and it is often marketed for its antioxidant properties.

However, there are not many studies that have looked into whether or not this supplement actually provides any cognitive benefits to people who take it.

In this article, we will explore some of the possible reasons why taking glutathione powder could be beneficial to your brain health and what you should know about using it safely before trying it out yourself.

So without further ado, let’s look at why Glutathione could be a useful nootropic to take if you want to improve your brain function.

What is Glutathione?

Glutathione is a substance that is naturally produced within the body and it has been called “the mother of all antioxidants” as it helps with detoxification.

It also plays a role in making sure that cells are healthy, repairing DNA damage, and preventing cell death from occurring by protecting against free radicals which can cause oxidative stress on our bodies if there isn’t enough glutathione present.

Glutathione is used by the body to make sure that there are enough antioxidants available in order to fight oxidative stress, but many of us do not get optimal levels due to our lifestyles and diet choices.

This can lead to impairments in cognitive function as well as other health problems such as atherosclerosis and neurodegenerative diseases.

For this reason, many people are now taking glutathione supplements in order to increase their antioxidant levels but do it really work?

What Does the Research Say?

There is some evidence that suggests that organic forms of Glutathione (GSH) could be useful as a nootropic supplement for people who want to improve their brain function.

In a study, older adults were given either GSH or placebo for 16 weeks and results showed that those who took the glutathione performed better on cognitive function tests than those who hadn’t.

The researchers concluded by saying “Oral GSH supplementation was effective at reversing age-related cognitive decline in healthy older adults.”

In another study using animal models, it has been suggested that glutathione could be useful for improving memory and learning ability as well as protecting the brain against oxidative stress caused by neurotoxicity (which can occur when substances such as mercury bind with glutathione).

In this study, it was found that the glutathione actually restored many of the cognitive dysfunctions caused by neurotoxicity and it reduced oxidative stress in order to protect against further damage.

The researchers concluded, “These findings highlight a novel mechanism for GSH neuroprotection following [mercury] exposure and suggest that GSH preconditioning may be a promising neuroprotective strategy against neurotoxicity-mediated oxidative stress.”

In both of these studies, there was no evidence to suggest that the glutathione supplementation had any negative effects on cognition and it actually helped improve cognitive function.

What are the benefits of Glutathione?

There are many benefits associated with taking Glutathione as a nootropic supplement and these can be very useful for people who want to improve their brain function.

These include:

  • Helping reduces oxidative stress which has been linked to the development of neurodegenerative diseases such as Parkinson’s disease, Alzheimer’s disease, and multiple sclerosis.
  • Protecting against the damage caused by neurotoxicities such as mercury poisoning or other environmental toxins which could affect brain health.
  • Decreasing levels of homocysteine in the body, helping to reduce cardiovascular risks such as atherosclerosis and stroke which can also affect cognitive function.
  • Helping increase white blood cells in order to help fight infection.
  • Increasing the production of natural killer cells which are important for fighting off cancerous tumors and improving immune system function.
  • Improving mood by helping produce dopamine, serotonin, and norepinephrine in the brain can help improve cognitive functions but also affect our psychological health too.

It's worth noting that some people may experience side effects when taking glutathione. Let's take a closer look at those below.

Are There Any Negatives?

The only downside to taking glutathione for cognitive benefits is that it can cause some unpleasant side effects such as nausea, vomiting, and diarrhea.

However, this only happens in a very small percentage of people who take these supplements so it isn’t something to be overly concerned about.

In addition, there have been no studies that show that there are any negative effects on people who take glutathione for cognitive benefits.

Glutathione is an antioxidant that has many health benefits in the body and it could also be useful as a nootropic supplement, but make sure to talk to your doctor before using it yourself.

This will ensure that you know how much you should be taking and what the potential side effects may be.

If you’re interested in using glutathione as a nootropic, make sure to take the organic form and start at low dosages before building up to avoid any side effects.

You should also consider taking it with an absorption support supplement such as alpha-lipoic acid or NAC (which will improve its uptake within the body) and be sure to drink plenty of water throughout the day, especially on an empty stomach.

Glutathione's role in cognitive function

Glutathione helps to protect and regenerate neurons in the brain which can help improve cognitive function.

Glutathione protects against neurotoxicities such as mercury poisoning or other environmental toxins which can affect levels of glutathione within the body, leading to oxidative stress and impaired cognition.

It has also been shown to increase the production of natural killer cells (important for fighting off cancerous tumors) and improve immune system function to help with overall cognitive health.

People also take it for its mood-boosting properties which can affect cognitive function too.

How does glutathione work to improve cognition?

As briefly mentioned above, glutathione helps protect, regenerate and repair neurons which are important for cognitive function.

It does this by protecting the mitochondria within cells from oxidative damage caused by free radicals (by acting as an antioxidant) but also because it has been shown to strengthen neuronal membranes too.

Glutathione is not only useful in helping improve cognitive function but it can also help improve mood which in turn contributes to cognitive function.

As well as helping produce dopamine, serotonin and norepinephrine (known as the ‘happy neurotransmitters’) glutathione has been shown to increase levels of BDNF (brain-derived neurotrophic factor), an important growth hormone for neural tissue.

All in all, taking glutathione as a nootropic can be useful for protecting and repairing neurons which is important for cognitive function.

Who is Glutathione good for?

Glutathione is good for anyone who wants to improve cognitive function and protect themselves from neurotoxicity or environmental toxins.

If you’re interested in boosting mood, it may also help with that too although there are other supplements which can be used more specifically for this purpose such as Rhodiola Rosea.

Those looking to use glutathione for its antioxidant properties should know that it is not a general antioxidant and does not have the same effect as other antioxidants such as vitamin C.

It’s also good for anyone who wants to improve their immune system function which can help with cognitive health too by protecting against illnesses or infections of the brain, eyes or ears.

In particular, those with autoimmune conditions such as Lupus and Parkinson’s disease may find it particularly useful.

However, just like with any health supplement or nootropic, you should always check with your doctor before using glutathione to make sure that there are not any contraindications for use (such as current medical issues) and ensure the dosage is appropriate.

Conclusion

Glutathione is a useful supplement to use as part of your nootropic stack.

It can be particularly helpful for protecting and repairing neurons which are important for cognitive function.

It also has mood-boosting properties which contribute to cognitive function too.

You can use glutathione as a standalone supplement or combine it with other nootropics such as Rhodiola Rosea for an even greater effect on your cognition and brain health.



source https://nootropicology.com/glutathione/
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Monday 27 May 2024

5 Benefits of Sabroxy: Powerful Nootropic For Cognitive function

Oroxylum_sabroxy
Oroxylum_sabroxy


There are many benefits to taking Sabroxy.

First off, it is a very powerful nootropic that has the ability to improve cognitive function and facilitate an increase in mental energy.

In this article, I'll be looking at 5 of the benefits of this product, so you can decide if it is right for you!

So without further ado, let's just get straight into it, shall we?

First things first, what is Sabroxy?

Sabroxy (or Oroxylum Indicum) has been used in traditional Ayurvedic medicine to treat and prevent a variety of ailments and may have neuroprotective effects.

Sabroxy® is a standardized extract comprised of the dried bark, which contains at least 10% Oroxylin A to help boost memory and support cerebral functions.

Oroxylin A is a flavone that is O-methylated from Scutellaria baicalensis and Scutellaria lateriflora plants as well as the Oroxylum Indicum tree.

Oroxylum Indicum is an Asian plant that has a long history of usage in Ayurveda.

In Ayurveda, the bark of the tree, which is high in Oroxylin A, is used to enhance the immune system and cognitive function.

Oroxylin A has been studied in several countries and has a varied profile of effects, ranging from:

  • Increases focus, motivation, and energy
  • Supports healthy inflammation levels
  • Provide better skin health and immune system function.

Oroxylin A has also been found to enhance CREB and BDNF, two important brain proteins that are critical for cognitive function and neurogenesis.

This study reveals that these interactions enhance NMDA signaling as well, which aids in neurogenesis.

It is also important to note that Oroxylin A has been shown to aid in the release of dopamine and acetylcholine, which are two neurotransmitters that play a key role in cognitive function.

Let's take a closer look at each benefit down below.

5. Improves cognitive function

As I mentioned previously, Sabroxy contains Oroxylin A which has been shown to increase the production of CREB and BDNF proteins in your brain.

These are two proteins that play a key role in memory formation.

A study conducted on mice found that Oroxylin A increased long-term potentiation (LTP) and memory formation in these animals.

Other studies have found that it can also aid the release of dopamine, which is important for focus and concentration during cognitive tasks.

Another study on rats with Alzheimer's Disease (AD), showed a significant improvement in cognition when compared to the control group after treatment with Oroxylin A over an extended period of time.

If you are looking for a nootropic that can improve your memory, then Sabroxy is a perfect choice!

4. It can improve memory recall

Memory recall, or the ability to quickly remember information that you have recently learned is another benefit of taking Sabroxy.

BDNF and CREB are proteins in your brain that are critical for proper cognitive function and neurogenesis.

In a study, Oroxylin A was shown to improve memory recall and learning ability in animals that were given a dose of the extract prior to taking part in an exercise designed for cognitive training.

Oroxylin A also improved short-term working memory as well as long-term memory formation during this process.

In addition, it was able to increase NMDA receptor activity which promotes neurogenesis.

3. It can improve your mood

In a study in mice, Oroxylin A was shown to have powerful antidepressant effects.

It was able to decrease fear and anxiety in these animals by blocking the NMDA receptor.

Similar results were found in another rat study that looked at how this extract affects depressive behaviors after traumatic brain injury (TBI).

Oroxylin A was able to reduce depressive symptoms in these animals when given before, during, and after TBI.

It also reversed the deficits in memory formation associated with brain injury and reduced anxiety levels as well.

Since many individuals who suffer from depression have underlying inflammation issues within their bodies, it is important to note that Oroxylin A has been shown to aid in healthy inflammation levels as well.

In a study, it was found that Oroxylin A reduced depressive symptoms and inhibited the release of pro-inflammatory cytokines when compared to the control group.

This shows how Oroxylin A in Sabroxy can not only improve your mood but also reduce any underlying inflammation that may be causing depressive behavior.

2. Improves skin quality

When it comes to skin health, Oroxylin A has been shown to be a powerful antioxidant that can aid in the formation of collagen and elastin as well.

In tests, it was found that this extract increased both proteins by stimulating their respective synthesis enzymes.

It also had an anti-aging effect on these animals due to its ability to suppress the release of collagenase, an enzyme that breaks down collagen in your skin.

Oroxylin A also has potent anti-inflammatory properties which can aid with redness and inflammation on various parts of your body.

But it doesn't stop there; Oroxylin A is able to penetrate into deeper layers of the dermis and can aid in diminishing wrinkles and other signs of aging.

This is because it inhibits the release of MMP-2, an enzyme that breaks down collagen.

1. Promotes immune health

Sabroxy has powerful antioxidant properties that can help aid your body in fighting off free radicals and toxins.

In a study, Oroxylin A was shown to be effective against oxidative stress from glutamate toxicity by enhancing T-cell production.

In addition to this, Oroxylin A was able to reduce the production of inflammatory cytokines such as tumor necrosis factor (TNF) and interleukin 17a (IL17A).

It also reduced levels of nitric oxide which promotes diseases such as asthma and atherosclerosis.

Oroxylin A also has anti-inflammatory properties which help to reduce the symptoms of various autoimmune diseases such as lupus, rheumatoid arthritis, and type I diabetes.

What is the most optimal Sabroxy dosage?

Sabroxy can be taken in one of two ways, either by purchasing capsules or buying the powder.

If it's your first time taking Sabroxy, I recommend taking 100mg in the morning on an empty stomach.

Beginners should start off with 100mg and work their way up from there until they find out what dosage works best for them.

You can also stack Sabroxy with other popular nootropics like; L-theanine and caffeine.

FAQ

What is Sabroxy?

Sabroxy is a standardized extract derived from the Indian trumpet tree's dried bark, which has at least 10% Oroxylin A to aid memory and neurodendritic functioning.

How do you take Sabroxy?

The best Sabroxy dosage to start off with is 100 mg taken once a day on an empty stomach. Preferably earlier in the day.

Where can I buy Sabroxy?

You can find Sabroxy in powder and capsule form on Nootropicdepot.



source https://nootropicology.com/sabroxy/
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Sunday 26 May 2024

8 Best Nootropic Stacks In 2024

best-nootropic-stacks

In this article, I'll take a closer at the 8 best nootropic stacks. I'll cover the potential risks and side effects you may run into, as well as the benefits you can expect.

As the world of nootropics expands, it can be difficult to know which stacks are worth trying. Nootropic stacks offer a powerful way to enhance cognitive performance and unlock your full potential.

According to a recent report by Grand View Research[1], the global nootropics market size is expected to be valued at USD 29.24 billion by 2028 and is projected to grow at a compound annual growth rate (CAGR) of 15.0%.

The report also states that the market was valued at USD 10.67 billion in 2021. But with so many different options on the market, it’s easy to get overwhelmed.

To simplify things, let's look at the 8 most highly-rated nootropic stacks based on users' reviews, scientific studies, and clinical trials.

The 8 best nootropic stacks, according to scientific evidence, are:

  • Nooceptin
  • Vyvamind
  • Mind Lab Pro
  • NooCube
  • L-Theanine + Caffeine
  • Piracetam + Alpha GPC
  • Modafinil + CDP Choline
  • Noopept + Phenibut

1. Nooceptin

Unlock your full mental capacity with the help of Nooceptin (FDG-117). This amazing nootropic blend contains 7 scientifically verified nootropic ingredients, providing energy and clarity for excellent focus.

With this powerful brain enhancer in today's increasingly competitive climate, let its incredible benefits give you that extra edge to stay ahead of the game.

The Nooceptin nootropic ingredients are:

  1. Citicoline (as CDP Choline aka cytidine 5'-phosphocholine, sodium)
  2. Rhodiola Rosea 150 mg Extract (3% rosavins & 1% salidroside) 
  3. Bacopa Monnieri Extract - 150 mg (40% bacosides)
  4. L-Theanine (L-γ-glutamylethylamide) - 200 mg 
  5. Ginkgo Biloba Extract - 100 mg (24% ginkgo flavone glycosides & 6% terpene lactones) 
  6. Lion's Mane Mushroom Extract - 400 mg (30% polysaccharides)
  7. Panax Ginseng Extract - 200 mg

With the power of Ginkgo Biloba, L-Theanine, Citicoline, and Rhodiola Rosea combined into one powerful stack, your brain will function optimally while feeling energized all day long.

Combining these nootropic ingredients is a powerful way to combat stress. They can offer you the perfect balance between calming mental alertness and, according to research on Citicoline, improvements in cognitive abilities as well[2] and Rhodiola Rosea can increase concentration capabilities, memory, and learning for peak focus.[3]

Nooceptin Pros

  • An all-natural nootropic stack available without a prescription
  • Contains 7 scientifically verified nootropic ingredients
  • Improves cognitive abilities, and mental alertness
  • You get more bang for your buck

Nooceptin Cons

  • The shipping time may take up to 2 weeks

Nooceptinin in Summary

If you're looking for a potent nootropic stack that can help unlock your full mental capacity and provide energy for peak focus, then Nooceptin is an excellent choice. It contains 7 nootropic ingredients scientifically verified to improve cognitive abilities and mental alertness.

You get more bang for your buck with its fast-acting ingredients and affordable cost.

2. Vyvamind

Unveiling the hidden potential of your brain, Vyvamind (NSV-313) is a culmination of 6 all-natural nootropic ingredients in perfect harmony. Experience unparalleled cognitive enhancement to take on any intellectual challenge.

Vyvamind is a complete nootropic stack that provides mental clarity, focus, and energy that can last for hours and accumulate effects lasting for weeks. Its powerful ingredients are:

  1. Vitamin B6 (2.5 mg)
  2. Vitamin B12 (50 mcg)
  3. L-Tyrosine (300 mg)
  4. Citicoline (CDP Choline) - 200 mg
  5. L-Theanine (150 mg)
  6. Caffeine Anhydrous (75 mg)

CDP Choline acts as the fundamental precursor to Acetylcholine (ACh), replenishing this essential neurotransmitter, emboldening learning and memory formation while also conferring neuroprotection - which scientific studies have demonstrated can protect against Alzheimer's Disease and other neurological illnesses.[4]

L-Tyrosine has the potential to unlock remarkable benefits for mental performance.

By leveraging this amino acid's natural properties, it is possible to bolster alertness and vigilance and increase levels of dopamine, norepinephrine, and epinephrine - 3 powerful neurotransmitters that can lead to superior cognitive functioning.[5]

Vyvamind Pros

  • Contains 6 scientifically verified and potent nootropic ingredients
  • Improves cognitive abilities, focus, and energy
  • Utilizes natural ingredients with minimal side effects
  • A potent nootropic stack for beginners and advanced users alike

Vyvamind Cons

  • Not ideal for people on a tight budget

Vyvamind in Summary

If you're looking for a powerful nootropic stack that can help unleash your hidden potential and provide energy for peak focus, Vyvamind is an excellent choice. It contains 6 nootropic ingredients scientifically verified to improve cognitive abilities, focus, and mental alertness.

You get full value from its potent ingredients with minimal side effects and fast-acting results. The downside is that it may be a bit pricey for some, but it's well worth the price.

3. Mind Lab Pro

Mind Lab Pro is a complete nootropic stack containing 11 natural ingredients synergistically formulated to unlock your brain's full potential.

If you're looking for a powerful nootropic stack that can help enhance cognitive performance without any jitters or crashes, Mind Lab Pro is an excellent choice.

Mind Lab Pro's ingredients include:

  1. Vitamin B6, 2,5 mg
  2. Vitamin B9, 100 mcg
  3. Vitamin B12, 7.5 mcg
  4. L-theanine, 100 mg
  5. Citicoline, 250 mg
  6. Bacopa monnieri, 150 mg
  7. Organic lion’s mane mushroom, 500 mg
  8. Phosphatidylserine, 100 mg
  9. N-acetyl L-tyrosine, 175 mg
  10. Rhodiola rosea, 50 mg
  11. Maritime pine bark extract, 75 mg

Mind Lab Pro provides your brain with essential nourishment to help you stay ahead of the mental fatigue that may come from a life in motion.

Vitamin B complex is one such nutrient, breaking down into ATP[6], which serves as fuel for your most vital organ's energy needs - without it, no ideas can sparkle or bloom! Keep up an active lifestyle, and know Mind Lab Pro has got you covered.

Mind Lab Pro Pros

  • Contains 11 scientifically verified and potent nootropic ingredients
  • It provides brain-boosting effects without any jitters or crashes
  • Utilizes natural ingredients with minimal side effects
  • An excellent nootropic stack for beginners and experts alike

Mind Lab Pro Cons

  • More expensive than other stacks on the market

Mind Lab Pro in Summary

Mind Lab Pro is a powerful nootropic stack that not only provides essential nutrition for your brain but also helps to enhance cognitive performance without any jitters or crashes. It contains 11 nootropic ingredients scientifically verified to improve cognitive abilities and focus while providing mental alertness.

You get full value from its potent nootropic ingredients with minimal side effects and fast-acting results.

4. NooCube

Like Mind Lab Pro, Vyvamind, and Nooceptin, NooCube is a nootropic stack that offers remarkable cognitive benefits. It contains 13 scientifically tested ingredients designed to help you stay focused and energized for longer periods.

NooCube’s ingredients include:

  1. Lutemax® 2020
  2. Bacopa Monnieri 12:1 (20% bacosides) 250 mg
  3. Huperzia Serrata (0.5% huperzine-a) 20 mg
  4. Pterostilbene 140 mcg
  5. Resveratrol 99% 14.3 mg
  6. L-Theanine 100 mg
  7. L-Tyrosine 250 mg
  8. Alpha GPC (Glycerylphosphorylcholine) 50 mg
  9. Oat Straw Extract 10:1
  10. Cat's Claw 4:1
  11. Vitamin B1 1.1 mg
  12. Vitamin B7 50 mcg
  13. Vitamin B12 2.5 mcg

An intriguing addition to NooCube is Resveratrol (3,5,4′-trihydroxystilbene), a polyphenol found in red wine and blueberries. Besides its antioxidant properties, research has shown that Resveratrol can enhance memory and cerebral blood flow.[7]

NooCube Pros

  • Contains 13 scientifically backed ingredients
  • It provides brain-boosting effects
  • Provides mental alertness and focus
  • Increases cerebral blood flow
  • A complete nootropic stack

NooCube Cons

  • The dosage of each ingredient could be higher

NooCube in Summary

NooCube is a complete nootropic stack that combines 13 scientifically tested ingredients specifically designed to help you stay focused and energized. Its unique blend of ingredients provides brain-boosting benefits, mental alertness, and increased cerebral blood flow.

It’s an excellent nootropic stack for those looking for a cognitive boost without the side effects of many prescription medications.

5. L-Theanine + Caffeine

L-Theanine and Caffeine is one of the most popular nootropic stacks available and is an excellent choice for those looking for an immediate boost in mental alertness. The combination of L-Theanine and Caffeine helps to improve focus and cognitive performance by calming the mind while simultaneously providing a light energy boost.

L-Theanine is an amino acid shown to help reduce stress, anxiety, depression, and improve cognitive performance.[8] Caffeine, on the other hand, is a powerful stimulant that can help boost energy and alertness.

When stacked in the right dosage, L-Theanine + Caffeine offers an ideal balance of calming effects and increased mental alertness without any jitters or crashes.[9]

L-Theanine + Caffeine Pros

  • An all-natural nootropic stack
  • L-Theanine helps buffer the effects of caffeine
  • Provides calming and mental alertness
  • No jitters or crashes

L-Theanine + Caffeine Cons

  • It can cause drowsiness in high dosages due to L-Theanine

L-Theanine + Caffeine in Summary

Available in most supplement stores, L-Theanine + Caffeine is an all-natural nootropic stack that combines the calming effects of L-Theanine with the stimulatory benefits of caffeine. This stack offers a balance of calming and energy effects without any jitters or crashes.

It’s an excellent choice for those looking for a quick boost in mental energy and alertness without the side effects of many prescription medications.

6. Piracetam + Alpha GPC

Piracetam + Alpha GPC is a powerful nootropic combination that helps to improve learning, memory, and overall cognitive performance. Piracetam is considered the original nootropic and is a derivative of the neurotransmitter GABA.[10] It helps to improve mental energy, focus, and alertness.

Alpha GPC is a natural choline compound that helps to promote the production of acetylcholine, a neurotransmitter responsible for learning and memory.[11] When stacked together, Piracetam and Alpha GPC offer a potent cognitive boost for those looking to improve their learning and memory. Both Alpha GPC and Piracetam have robust scientific evidence backing up their efficacy.

Piracetam + Alpha GPC Pros

  • Powerful nootropic stack for learning and memory
  • Piracetam and Alpha GPC have robust scientific evidence behind them
  • No jitters or crashes
  • Improves cognitive performance
  • Increases the production of acetylcholine (ACh)

Piracetam + Alpha GPC Cons

  • It can be hard to find high-quality Piracetam online

Piracetam + Alpha GPC in Summary

Piracetam + Alpha GPC is a powerful nootropic stack with robust scientific evidence. This stack helps to boost learning, memory, and cognitive performance while also increasing the production of acetylcholine (ACh). It’s ideal for those looking to improve their overall mental performance.

7. Modafinil + CDP Choline

Modafinil, otherwise known as Provigil, is a powerful CNS stimulant that helps those suffering from narcolepsy, shift work disorder, and obstructive sleep apnea to combat exhaustion.

Yet this medication does more than just fight fatigue - it has the potential to enhance focus on concentration for students studying hard or professionals searching for improved productivity. It works by increasing catecholamines like dopamine and norepinephrine, resulting in improved focus, alertness, and mental energy.[12]

CDP Choline, otherwise known as Citicoline, cytidine diphosphate-choline or cytidine 5'-diphosphocholine, is a powerful intermediary in the transformation of choline into phosphatidylcholine. This biochemical reaction is found ubiquitously throughout cell membranes and human/animal tissue - especially in organs.[13]

Citicoline itself occurs naturally within cells and helps to improve mental energy and focus. Combined with Modafinil, it produces a powerful nootropic stack that helps enhance alertness and concentration while reducing fatigue.

Since CDP Choline is a choline source, it helps buffer Modafinil from overstimulating the nervous system. This stack is great for those looking for improved concentration and focus without jitters, headaches, or crash.

Modafinil + CDP Choline Pros

  • CDP Choline occurs naturally within cells
  • Powerful nootropic stack for concentration and focus
  • The combination helps buffer Modafinil from overstimulating the nervous system
  • Increases catecholamines such as dopamine and norepinephrine
  • No jittery side effects or headaches

Modafinil + CDP Choline Cons

  • Modafinil is a prescription drug

Modafinil + CDP Choline in Summary

Modafinil is one of the most powerful nootropic drugs, and when combined with CDP Choline, it forms a potent cognitive stack. This combination helps improve concentration and focus while reducing fatigue.

It also helps buffer Modafinil from overstimulating the nervous system and increases catecholamines such as dopamine and norepinephrine.

8. Noopept + Phenibut

N-Phenylacetyl-l-prolylglycine ethyl ester, commonly known as Noopept, is a prodrug and nootropic discovered in 1996. It has additional names, such as GVS-111 and omberacetam.

Noopept is widely used as a brain enhancer in the nootropic community. According to preclinical studies, the mechanisms of action include boosting acetylcholine signaling, promoting BDNF and NGF expression, protecting against glutamate toxicity, and augmenting inhibitory neurotransmission within the brain.[14]

Phenibut is an engineered form of gamma-aminobutyric acid, more commonly referred to as GABA. It shares many similarities in structure but can yield powerful results when used correctly and safely.

Phenibut is a tranquilizer that has anxiolytic properties and improves mood. It helps reduce stress, anxiety, fear, and depression while improving cognition.[15]

When Phenibut and Noopept are stacked together, it creates a powerful cognitive stack that is great for focus, productivity, relaxation, and mental energy. This stack helps to enhance cognition, reduce anxiety and stress levels, improve mood, and can be the ideal stack for socialization.

Noopept + Phenibut Pros

  • Powerful cognitive stack for focus and productivity
  • Reduces stress, anxiety, fear, and depression
  • It improves mood and can be beneficial for socialization

Noopept + Phenibut Cons

  • Phenibut can be addictive (cause withdrawals)
  • Hard to find high-quality Noopept

Noopept + Phenibut in Summary

Phenibut has powerful anti-anxiety and tranquilizer effects, while Noopept boosts cognition. They create a powerful cognitive stack that is great for focus, productivity, relaxation, and mental energy.

This combination helps to reduce stress and anxiety levels while improving mood and socialization skills.

What Are the Best Nootropic Stacks?

best nootropic stacks

The best nootropic stacks, according to my market research, are:

  1. Nooceptin
  2. Vyvamind
  3. Mind Lab Pro
  4. NooCube
  5. L-Theanine + Caffeine
  6. Piracetam + Alpha GPC
  7. Modafinil + CDP Choline
  8. Noopept + Phenibut

I've chosen a mix of nootropic blends, synthetic and natural compounds to provide a comprehensive list of the best nootropic stacks.

I've extensively researched each product and believe these are the most effective alternatives for optimizing cognitive function, mental performance, focus, motivation, creativity, and productivity.

The nootropic stacks on my list are reliable and have been tested in rigorous clinical trials. This means that whatever stack you choose will provide the desired results and help you achieve peak productivity.

It's worth pointing out that these nootropic stacks are meant to be combined with healthy lifestyles and nutrition habits. Diet, exercise, and a good night's sleep all play an important role in optimizing cognitive function.

How to Choose the Right Nootropic Stack?

Your right nootropic stack will depend on your needs, goals, and lifestyle.

If you're looking to optimize mental performance or focus, I recommend combining L-theanine and caffeine. This natural stack helps to improve concentration and alertness without causing any side effects. It can also help reduce stress, improve cognitive performance, and boost overall energy.

If you're looking for a more potent stack, I recommend Nooceptin or Vyvamind. These blends contain several active compounds that enhance cognition, boost focus and productivity, and provide long-lasting mental energy.

When choosing a nootropic blend, it's important to go with one with the right amount of active ingredients. Too much of a certain compound can cause side effects or even reduce the blend's effectiveness.

What Are the Benefits of Nootropic Stacks?

The benefits of nootropic stacks vary from person to person. However, there are some general benefits that most people experience:

  • Improved cognitive function: Nootropic stacks can improve memory recall and concentration while boosting mental energy.
  • Enhanced focus: The stimulants in nootropic blends boost alertness and help you focus on tasks for longer periods.
  • Better mood: Nootropic stacks can reduce stress and anxiety, which in turn helps to improve mood.
  • More productivity: The blend of stimulants and relaxants increases productivity by helping you stay focused on the task at hand.
  • More cost-effective: Nootropic stacks are more cost-effective than buying individual nootropic compounds.

Nootropic stacks are an excellent way to optimize cognitive function and mental performance. You can increase focus, reduce stress, and improve productivity with the right blend of ingredients.

What Are the Side Effects of Nootropic Stacks?

The most common side effects of nootropic stacks are headaches, irritability, and stomach upset. Many of the ingredients in these blends can have mild side effects if taken in large doses or used for extended periods of time.

It's important to use high-quality products from reputable sources and follow the dosage instructions carefully to minimize potential side effects. You should consult a physician if you experience any adverse effects.

It's worth noting that synthetic nootropics like Phenibut can be addictive and should be used cautiously. Plenty of personal stories on the internet serve as a cautionary tale for those considering using Phenibut as a part of their nootropic stack.

Do Nootropic Stacks Really Work?

So do I personally think that nootropic stacks work? Yes, I do.

I've seen first-hand the effects of these nootropic blends on my mental performance. I have personal experience using Nooceptin, Vyvamind, Mind Lab Pro, and NooCube, and I've experienced noticeable improvements in my concentration, focus, and productivity levels.

I've found that nootropic blends, like the above, contain just the right amount of each active ingredient. This helps to reduce any potential side effects and maximize their effectiveness in terms of improving cognitive performance.

Modafinil and CDP Choline used to be my main go-to nootropic stack, but now I prefer the natural nootropic stacks, like Nooceptin and Vyvamind. They are natural, have fewer side effects, and the long-lasting benefits are great for those who want to get more done over a longer period of time.

So if you're looking to optimize mental performance and increase concentration, my advice is to give one of these natural nootropic stacks a try.

My Final Thoughts

So what do we know about the best nootropic stacks?

We know that they can provide long-lasting increases in cognitive function, focus, and productivity. We also know they come with potential side effects if taken improperly.

When choosing a nootropic stack, make sure to do your research and select one that has the right amounts of each active ingredient. Pay attention to the dosage instructions, and consult a doctor if you experience any adverse effects.

Nootropic blends like Nooceptin, Vyvamind, Mind Lab Pro, and NooCube are all great options if you're looking to increase mental performance. My personal favorite is Nooceptin which contains an optimal blend of natural, clinically proven ingredients.

Thanks for reading! I hope this article has shed some light on the best nootropic stacks. Happy stacking! 🙂

References
  1. Nootropics market size & share analysis report, 2028. Nootropics Market Size & Share Analysis Report, 2028. (n.d.). Retrieved February 9, 2023, from https://www.grandviewresearch.com/industry-analysis/nootropics-market
  2. Al-Kuraishy, Hayder M, and Ali I Al-Gareeb. “Citicoline Improves Human Vigilance and Visual Working Memory: The Role of Neuronal Activation and Oxidative Stress.” Basic and clinical neuroscience vol. 11,4 (2020): 423-432. doi:10.32598/bcn.11.4.1097.1
  3. Ma, Gou-Ping et al. “Rhodiola rosea L. Improves Learning and Memory Function: Preclinical Evidence and Possible Mechanisms.” Frontiers in pharmacology vol. 9 1415. 4 Dec. 2018, doi:10.3389/fphar.2018.01415
  4. Caamaño, J et al. “Effects of CDP-choline on cognition and cerebral hemodynamics in patients with Alzheimer's disease.” Methods and findings in experimental and clinical pharmacology vol. 16,3 (1994): 211-8.
  5. Jongkees, Bryant J et al. “Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands--A review.” Journal of psychiatric research vol. 70 (2015): 50-7. doi:10.1016/j.jpsychires.2015.08.014
  6. Kennedy, David O. “B Vitamins and the Brain: Mechanisms, Dose and Efficacy--A Review.” Nutrients vol. 8,2 68. 27 Jan. 2016, doi:10.3390/nu8020068
  7. Cicero, Arrigo F G et al. “Resveratrol and cognitive decline: a clinician perspective.” Archives of medical science : AMS vol. 15,4 (2019): 936-943. doi:10.5114/aoms.2019.85463
  8. Hidese, Shinsuke et al. “Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.” Nutrients vol. 11,10 2362. 3 Oct. 2019, doi:10.3390/nu11102362
  9. Owen, Gail N et al. “The combined effects of L-theanine and caffeine on cognitive performance and mood.” Nutritional neuroscience vol. 11,4 (2008): 193-8. doi:10.1179/147683008X301513
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