Oleamide is a naturally occurring chemical that has been studied for its neuroprotective and antidepressant effects.
It is also known as an endocannabinoid, which means it can bind to the same receptors in the brain that are targeted by marijuana.
Oleamide was discovered when scientists were doing research on oleic acid metabolism in rats.
They found that one of the metabolites they had created, called oleamide, had some interesting properties.
In this article, we're going to talk about what oleamide is, its effects on the brain and body.
We'll also look at some potential uses for this compound as a nootropic supplement. So without further ado, let's get started.
What is Oleamide?
Oleamide is a chemical that is derived from oleic acid.
It was first discovered in the blood of humans and animals as an endogenous compound, which means it occurs naturally within your body.
Oleamide works by binding to cannabinoid receptors CB1 and CB2, just like other cannabinoids such as tetrahydrocannabinol (THC) and THCV.
Oleamide is considered an endocannabinoid because it can produce effects similar to cannabinoids found in the cannabis plant, without causing any mind-altering or intoxicating effects at all.
It's metabolized by enzymes that are part of your body's innate immune system called fatty acid amide hydrolase (FAAH).
In addition to binding cannabinoid receptors in your brain, oleamide also binds serotonin and dopamine receptors.
This action has been found to help regulate other neurotransmitters, such as glutamate and GABA (gamma-aminobutyric acid).
Oleamide is able to bind all of these receptors because it has a similar structure to the endogenous cannabinoids that your body produces, called anandamide and arachidonoylethanolamine (AEA).
Oleamide's Effects on the Body and Brain
In a study looking at oleamide's effects on rats, scientists found that it increased their appetite.
They also saw an increase in locomotor behavior when they injected oleamide into rats' brains.
This is believed to be caused by its ability to bind to CB1-receptors in the hypothalamus, which is responsible for regulating locomotor behavior.
Oleamide also has neuroprotective effects.
It binds to adenosine A-type receptor sites and GABA C receptor sites both of which are known to be involved with mood regulation and stress response.
This helps protect your brain cells from damage, which is why it has been studied as a potential treatment for neurodegenerative diseases.
Oleamide also acts as an antidepressant in mice by binding to serotonin receptors and increasing the synthesis of serotonin.
It's currently being investigated for its therapeutic effects on human depression.
As you can see, oleamide has many interesting effects on the brain and body.
What is Oleamide Used For?
Oleamide has recently gained a lot of interest as a potential treatment for neurodegenerative diseases.
It has been studied in animal models of Alzheimer's Disease, Parkinson's Disease, and Huntington's disease to help protect brain cells from damage caused by these conditions.
Oleamide has also shown some promise as an antidepressant drug.
This is because it binds serotonin receptors and helps increase serotonin production in the brain.
It's also been shown to bind dopamine receptors, which may contribute to its antidepressant effects as well.
Oleamide is often combined with choline sources like Alpha GPC or Citicoline because its neuroprotective effects depend on an adequate supply of acetylcholine in your brain.
Biohackers also experiment with stacking oleamide together with other supplements like L-theanine, ashwagandha, or curcumin to help improve their focus and mood.
Some people have also found that taking oleamide together with a low dose of THC can produce interesting effects as well.
The combination has been called "the Entourage effect", which refers to the idea that cannabinoids work better together than they do alone.
This is because oleamide helps increase the permeability of cannabinoid receptors in your blood-brain barrier, which allows THC to cross into your brain more easily.
What are the benefits?
As briefly mentioned above, the benefits of Oleamide, when used as a Nootropic, are:
Protection of brain cells from damage
Helps regulate neurotransmitters such as serotonin, dopamine, and GABA
May act as an antidepressant in humans
Helps regulate mood and behavior
The benefits of Oleamide are well-established in the scientific literature.
However, there are also some potential side effects of taking oleamide as a nootropic supplement.
Let's take a closer look at those below.
What are the side effects?
Oleamide has been shown to have some side effects in clinical trials.
Some of these include headaches, nausea, and vomiting, stomach aches or pain, dizziness, or drowsiness.
However, it's important to note that oleamide is still being studied for its therapeutic potentials so there could be more negative side effects yet to be discovered.
That being said, most people don't experience any side effects when taking oleamide as a nootropic supplement.
What's the optimal dosage?
In terms of dosage, most studies have used a dose of around 200mg to 800mg per day for oleamide's nootropic effects.
It's important to note that the optimal dosage of Oleamide in a nootropic stack will depend on your goals and how it affects you personally.
People react differently to supplements, so it might be best for you to start with a low dose and work yourself up from there if necessary.
What I like about Oleamide
I like Oleamide for a number of reasons.
First, I have personally experienced the antidepressant effects of oleamide firsthand and found it to be quite effective in helping regulate my mood when dealing with anxiety or depression.
Second, oleamide is very well-tolerated by most people who take it as a nootropic supplement.
This makes it easier to experiment with different dosages and find what works best for you, without worrying about negative side effects.
Finally, oleamide seems to work synergistically with other nootropics like Alpha GPC or L-theanine, which means you can stack it together with these supplements for enhanced cognitive effects.
What I don't like about Oleamide
However, there are also some potential side effects of taking oleamide as a nootropic supplement.
Some of these include headaches, nausea, and vomiting, stomach aches or pain, dizziness, or drowsiness.
It's also unclear how oleamide works in our body at the molecular level to produce its beneficial effects on brain health and neurotransmitter regulation.
There are anecdotal reports online that taking Oleamide can cause a "strange" feeling in your body.
Some people have also reported negative effects such as jitters or irritability, which can be quite unpleasant if you don't take the right dosage for your individual needs.
Personally, I have only experienced drowsiness which can be quite annoying if you need to be alert and focused on a task.
In Summary
Oleamide is a natural nootropic supplement that has been shown to have neuroprotective and antidepressant effects in clinical trials.
It also doesn't seem to cause negative side effects when taken at the right dosage for your needs.
Luckily, Oleamide is very well-tolerated by most people who take it as a nootropic supplement.
This makes it easier to experiment with different dosages and find what works best for you, without worrying about negative side effects.
However, there are also some potential side effects of taking oleamide as a nootropic supplement.
Some of these include headaches, nausea, and vomiting, stomach aches or pain, dizziness, or drowsiness.
In this article, I'll look at the 8 most powerful nootropics. I'll also cover the potential risks and side effects you may run into and the benefits you can expect.
Nootropics come in all shapes and sizes, and it can be challenging to determine which one is best for you. The market is full of options, and it can sometimes be difficult to know which will work best.
Today I'll be discussing the 8 most powerful nootropics available in 2023. These have a proven track record and are backed by research, so you can be sure they'll provide the results you're looking for.
Let's see what Science says about these 8 brain boosters, shall we?
The most powerful nootropics, according to scientific evidence, are:
Lion's Mane Mushroom Extract - 400 mg (30% polysaccharides)
Panax Ginseng Extract - 200 mg
With the synergistic combination of Ginkgo Biloba, L-Theanine, Citicoline, and Rhodiola Rosea, you can unleash peak performance in all aspects of your life.
This powerful stack not only boosts mental alertness but also offers protection from stress, increasing concentration capabilities and improving cognitive abilities for maximum focus.
Rhodiola Rosea, in particular, has been shown to increase cognitive function, memory, attention span, and reduce stress.[1]
Nooceptin Pros
An all-natural blend containing 7 nootropics
Increases mental alertness and cognitive abilities
Protects from stress Improves memory, attention span, and focus
You don't need a prescription from your doctor
Nooceptin Cons
Shipping times can take up to 2 weeks
Nooceptin in Summary
Nooceptin is a nootropic blend, meaning it contains several different ingredients that have been scientifically tested and proven to help increase your focus, mental alertness, and cognitive abilities. This powerful combination of 7 nootropics will give you the energy and clarity of mind to reach peak performance in all aspects of your life.
2. Modafinil
Modafinil (Provigil) is a eugeroic (wakefulness-promoting) nootropic used to treat excessive sleepiness caused by narcolepsy, shift work disorder, and obstructive sleep apnea.
It is one of the most popular nootropics on the market as it has a long history of clinical use for treating excessive daytime fatigue in patients with narcolepsy.[2]
Modafinil has been found to remarkably affect the human brain, boosting dopamine levels far beyond what is considered clinically relevant. Remarkably, it does this by occupying and blocking the same binding site for cocaine in the striatum - an important area associated with reward motivation.[3]
While the precise mechanism of Modafinil is yet to be elucidated, Volkow, Nora D et al. suggest that it may act on certain areas in our brain related to hypocretin, histamine, epinephrine, γ-aminobutyric acid (GABA), and glutamate.
Modafinil Pros
Increases wakefulness and alertness
Improves cognitive abilities and focus
Reduces fatigue
One of the most powerful nootropics currently on the market
Modafinil Cons
You need a prescription from your doctor
Modafinil in Summary
Considered one of the most powerful nootropics currently on the market, Modafinil is a wakefulness-promoting drug widely used to treat narcolepsy and shift work disorders. It is known for increasing alertness and cognitive abilities and reducing fatigue. While it does require a prescription from your doctor, Modafinil can be a great choice for those looking to take their cognitive performance to the next level.
3. Armodafinil
Armodafinil (Nuvigil) is a newer version of Modafinil and shares many of the same benefits. It is slightly more powerful than Modafinil and has been found to have longer-lasting effects.
Armodafinil is the longer-acting isomer of Modafinil and is used to treat obstructive sleep apnea, narcolepsy, and shift work disorder. Compared with Modafinil, Armodafinil maintains higher plasma concentrations later in the day in healthy subjects.[4]
If you're looking for a powerful nootropic lasting up to 15 hours, then Armodafinil should be your go-to choice.
Armodafinil Pros
Longer lasting effects than Modafinil
Increases wakefulness and alertness
Improves cognitive abilities and focus
Reduces fatigue
Armodafinil Cons
Requires a prescription from your doctor
Armodafinil in Summary
Armodafinil is the newer and more powerful version of Modafinil. It maintains higher plasma concentrations later in the day and lasts up to 15 hours. Like its predecessor, Armodafinil increases wakefulness, alertness, cognitive abilities, and focus while reducing fatigue.
4. Phenibut
Phenibut (beta-phenyl-gamma-aminobutyric acid HCl) is an amazing neuropsychotropic drug that was discovered and first used in Russia during the 1960s.
Not only does it have anxiolytic properties, but it also increases cognition by mimicking GABA receptors of both types A and B.[5] Phenibut is considered a tranquilizer and nootropic drug and is widely used to ease anxiety, improve sleep quality, and reduce stress.
More recently, Phenibut has gained popularity among people with social anxiety and is often used to promote feelings of well-being. The downside of Phenibut is that it can be addictive and cause withdrawals in people who take it for too long.
That said, Phenibut is one of the most powerful nootropics on the market and can be a great choice for those looking to reduce anxiety and improve cognition.
Phenibut Pros
Anxiolytic properties
Improves sleep quality and cognitive abilities
Reduces stress levels
Promotes feelings of well-being
Phenibut Cons
It can be addictive with overuse
Tolerance can develop quickly with regular use
Phenibut in Summary
Phenibut is an amazing neuropsychotropic drug that has gained popularity among people with social anxiety. It is a tranquilizer and nootropic drug used to ease anxiety, improve sleep quality, reduce stress levels, and promote feelings of well-being. Despite its many benefits, Phenibut can be addictive and cause withdrawal when taken for too long. Therefore, using this nootropic wisely and taking breaks during long-term use is important.
5. Piracetam
Piracetam (2-oxo-1-pyrrolidine-acetamide) is one of the most widely used nootropic drugs and holds tremendous promise for optimizing brain function.
It's a cyclic derivative of gamma-aminobutyric acid, which increases learning abilities, memory retention capacity, and overall metabolism in cerebral activity.
Studies have demonstrated that Piracetam can modify the physical attributes of plasma membranes by making them more liquid and safeguarding cells from hypoxia (low levels of oxygen in body tissues).[6]
Piracetam is a versatile nootropic compound possessing antithrombotic, neuroprotective, and rheological properties. Restoring membrane fluidity through its interaction with phospholipids in the membranes of cells is highly efficacious for various disorders, from dementia and vertigo to myoclonus and stroke.
Piracetam Pros
Improves learning abilities and memory retention capacity
Reduces hypoxia
Modifies physical attributes of plasma membranes
Antithrombotic, neuroprotective, and rheological properties
Piracetam Cons
It can be difficult to obtain because it is unregulated in many countries
Piracetam in Summary
Piracetam is one of the most widely used nootropics and holds tremendous promise for optimizing brain function. It increases learning abilities, memory retention capacity, and overall metabolism in cerebral activity.
6. Noopept
Noopept (GVS-111), a proline-containing dipeptide, has both nootropic and neuroprotective properties. This remarkable compound can stimulate inhibitory interneurons in the hippocampus stratum radiatum, which is the area of the brain responsible for learning and memory.[7]
Noopept has shown remarkable potential in protecting the brain from various damaging forces, such as ionic disruption, excessive excitation of nerve cells, free radical formation, and pro-inflammatory cytokine accumulation.[8]
Its ability to prevent neurotrophin deficits - which are common features of neurological diseases like Alzheimer's Disease (AD) – has led researchers to investigate its neuroprotective action in various studies.
Noopept is a powerful ally in the fight against cognitive decline and numerous neurological diseases.
Noopept Pros
Stimulates inhibitory interneurons in the hippocampus stratum radiatum
Protects the brain from various damaging forces
Prevents neurotrophin deficits common to neurological diseases like Alzheimer’s Disease
Noopept Cons
More long-term studies are needed to understand the risks of long-term use
Noopept in Summary
Noopept is a proline-containing dipeptide with nootropic and neuroprotective properties. It can stimulate inhibitory interneurons in the hippocampus stratum radiatum, a brain area responsible for learning and memory. It has demonstrated the potential to protect the brain from various damaging forces.
7. L-Theanine + Caffeine
L-Theanine and Caffeine are two natural nootropic ingredients that, on their own, have powerful cognitive benefits. But when combined, they form a powerful duo that can improve mental performance, focus, alertness, energy levels and promote relaxation and well-being.
L-Theanine is an amino acid found in green tea that has been shown to reduce stress, relaxation, anxiety, and sleep quality.[9] It can also reduce the stimulating effects of caffeine, improving its overall efficacy.
Caffeine is a powerful stimulant that increases alertness and concentration; it has been used for centuries to improve cognitive performance. Caffeine also enhances memory, mood, reaction time, and decision-making skills.
One study aimed to compare the effects of 50 mg of caffeine with and without 100 mg of L-theanine on cognition and mood in healthy volunteers.[10]
The cognitive abilities tested included word recognition, rapid visual information processing, critical flicker fusion threshold, and attention switching. The mood was also assessed. 27 participants were tested at baseline and again 60 min and 90 min after each treatment (separated by a 7-day washout).
The results showed that caffeine improved subjective alertness at the 60 min mark and accuracy on the attention-switching task at 90 min.
Furthermore, the combination of L-theanine and caffeine improved both speed and accuracy of performance for the attention-switching task at 60 min. It also reduced susceptibility to distracting information in the memory task at both 60 min and 90 min marks.
This research indicates that when L-theanine and caffeine are combined, cognitive performance is heightened significantly, while distraction during memory tasks becomes a thing of the past.
These outcomes mirror other studies, demonstrating that combining these two nootropic ingredients can be highly advantageous for excelling in activities requiring intense mental focus.
L-Theanine + Caffeine Pros
An all-natural nootropic stack widely available in stores
Improves mental performance, focus, alertness, and energy levels
Reduces stress, relaxation, anxiety, and sleep quality
L-Theanine + Caffeine Cons
L-Theanine can cause drowsiness in high dosages
L-Theanine + Caffeine in Summary
L-Theanine and caffeine are two natural nootropics that have powerful cognitive benefits when used together. They can heighten mental performance, focus, alertness, and energy levels while reducing stress levels and promoting relaxation.
8. CDP-Choline
CDP-choline (cytidine-5'-diphosphocholine) is a phospholipid clinically proven to aid in treating cognitive disorders. It works by restoring and preserving brain cell membranes, thus allowing for improved mental health and performance.
It is a nootropic supplement that has been used to optimize cognitive performance by enhancing neurotransmission in the brain. It works by increasing the synthesis of acetylcholine (ACh), which is essential for many cognitive functions such as memory and learning.
CDP-choline acts on the Alpha7 nicotinic receptor, a type of receptor found in neurons throughout the brain, enabling improved communication between neurons. This can lead to faster and more efficient processing of information in the brain.[11]
According to Knott, Verner et al., CDP-choline can modulate brain waves and neural oscillations associated with cognitive processes through EEG (electroencephalography) recordings.
The EEG recordings have revealed that CDP-choline can induce dose-dependent changes in delta and alpha oscillations in healthy volunteers given both low (500 mg) and moderate (1000 mg) doses of CDP-choline when compared to placebo.
This effect is thought to be driven by increased cholinergic transmission resulting from increased acetylcholine synthesis with CDP-choline administration.
This makes CDP-choline a powerful nootropic if you're looking to optimize brain function and cognition.
CDP-Choline Pros
Can help treat cognitive disorders
Enhances neurotransmission in the brain
Increases acetylcholine synthesis for improved cognition
CDP-Choline Cons
Not as potent as other nootropics like Nooceptin and Modafinil
CDP-Choline in Summary
CDP-choline is a powerful nootropic compound clinically proven to aid cognition and brain function. It works by increasing acetylcholine synthesis, an essential neurotransmitter for many cognitive functions such as memory and learning.
What Are The Most Powerful Nootropics?
According to my market research, clinical trials, and user reviews, the 8 most powerful nootropics are:
Nooceptin
Modafinil
Armodafinil
Phenibut
Piracetam
Noopept
L-Theanine + Caffeine
CDP-Choline
My list contains a mix of natural and pharmaceutical compounds that have been tested for their cognitive enhancement capabilities.
All of these nootropics can be used to improve mental performance, focus, alertness, and energy levels while reducing stress levels and promoting relaxation.
If you're brand spanking new to the world of nootropic supplements, I highly recommend looking into nootropic blends like Nooceptin. With Nooceptin you get 7 all-natural nootropic ingredients that have been clinically tested and proven effective for cognitive enhancement.
It's a great starting point for anyone looking to experience the power of nootropics without having to take multiple supplements.
How to Choose The Most Powerful Nootropics?
When choosing which nootropic to take, it’s important to do your research and consider the pros and cons of each. Consider your goals for using a nootropic, as different types will be better suited for certain tasks.
Also, read up on reviews from other people who have used the product in question and the manufacturer’s instructions on how to safely use the nootropic. Your health should always be a priority, so ensure you read up on potential side effects before taking a new supplement.
There's a big difference between synthetic and natural nootropics, and it's important to be aware of the pros and cons of each type. Synthetics tend to be more effective but can also have more side effects than natural nootropics.
What Are the Benefits of The Most Powerful Nootropics?
The benefits of using some of the most powerful nootropics on the market are numerous. They range from improved mental performance, focus, and alertness to reduced stress levels and cognitive enhancement.
Synthetic nootropics such as Phenibut and Modafinil are some of the best for improving your productivity while providing you with long-term benefits such as better memory formation, learning speed, and increased relaxation.
Natural nootropics such as Nooceptin and L-Theanine + Caffeine are some of the healthiest alternatives as they are derived from natural sources and lack the harsh side effects often associated with synthetics.
When you use nootropic blends like Nooceptin you get the added bonus of having multiple nootropic ingredients working synergistically, meaning that they can provide greater benefits than a single nootropic.
What Are the Side Effects of The Most Powerful Nootropics?
The side effects come from various factors, including the type of nootropic you’re taking, your body chemistry, and pre-existing medical conditions.
That being said, some common side effects associated with the most powerful nootropics include headaches, nausea, and dizziness. Modafinil and Phenibut can cause more serious side effects. Phenibut can cause severe withdrawals when used in high doses, so it’s important to discuss with your doctor how much is safe for you.
Modafinil has been associated with a rare skin condition called Stevens-Johnson Syndrome. It’s important to pay attention to any changes in your skin after taking Modafinil and discuss them with your doctor.
Do The Most Powerful Nootropics Really Work?
So do these powerful nootropics on my list really work? The answer is yes.
These nootropics have been clinically tested and proven to provide cognitive enhancement, focus, alertness, improved mental performance, and energy levels while reducing stress and promoting relaxation.
Synthetics may be more effective, but they come with the risk of possible side effects, so it’s important to discuss with your doctor which type of nootropic would be best for you.
Natural nootropics are safer and have fewer risks, so they’re great for beginners or people who are more sensitive to the effects of synthetic nootropics.
Final Thoughts
So what do we know about the most powerful nootropics?
We know they can help improve mental performance, focus, alertness, and cognitive function while reducing stress levels. Some synthetic nootropics can be more effective than natural nootropics but come with the risk of side effects.
We also know that nootropic blends like Nooceptin can provide greater benefits than a single nootropic on its own. This is because different ingredients work together synergistically, meaning that they can provide more efficient and greater results.
So if you're looking for a powerful ally to help you stay sharp and focused, the most powerful nootropics are definitely worth considering!
It's been a while since we have seen any new nootropic developments.
This is what makes the recent discovery of functional yeast extract so exciting.
In this article, I'm going to introduce you to a new type of nootropic that has been gaining popularity recently among students and professionals alike - functional yeast extract.
We will look at what functional yeast extract is, its potential benefits, and how to take it. So without further ado, let's get started!
What is Functional Yeast Extract?
The term "yeast extract" refers to yeast extracts produced by removing the cell walls from the yeast cells and extracting the cell contents.
Yeast extract is commonly used in foods as a flavor enhancer and food additive.
Yeast extract is a liquid or powdery form of yeast. Yeast extract can be found in a variety of foods including crackers, gravy, and frozen meals.
Saccharomyces cerevisiae is a strain of yeast that has been used in the production of bread, beer, and winemaking for thousands of years. It was discovered by dipping grape skins into wine.
Yeast extracts are high in B vitamins, especially B1-3, B6, and B12.
B Vitamins have been implicated in the breakdown of carbohydrates, proteins, and fats into usable energy. Vitamin B12 has been observed to improve mood in several studies.
During fermentation, yeasts produce beta-glucans.
Beta-glucans are sugars that may be found in the cell walls of yeasts, fungus, bacteria, algae, and other plants.
Beta-glucans have been used for health benefits on occasion.
The primary advantage of yeast extract is the presence of beta-glucans.
What are Beta Glucans?
As briefly mentioned above, beta-glucans are sugars that may be found in the cell walls of yeasts, fungus, bacteria, algae, and other plants.
Beta-glucan is a soluble fiber known as "yeast polysaccharide."
Yeast extract contains up to 50% beta-glucans by weight! That's an incredible amount.
In fact, yeast extract contains more beta-glucans than other dietary sources of soluble fiber.
Beta-glucan is a type of polysaccharide that has been associated with the maintenance and improvement of overall immune function in humans, but it can benefit your brain as well!
When you take it as a Nootropic supplement, the beta-glucans in yeast extract may enhance cognition by stimulating neuron growth and protecting neurons.
What are the benefits of yeast extract?
The benefits of yeast extract are often attributed to the presence of beta-glucans.
Beta-glucan is known for its anti-viral and anti-bacterial properties, but it also has a number of cognitive benefits as well!
In addition to improving your immune system and supporting cardiovascular health, beta-glucan may enhance cognition by stimulating neuron growth and protecting neurons in the brain.
The abundance of beta-glucans in yeast extract may also enhance overall cognitive function, improving memory and focus in healthy individuals.
How do I take yeast extract?
While you can find yeast extracts in a variety of foods, the best way to obtain them is through supplementation.
If you are interested in taking functional yeast extract as a supplement, make sure that it contains at least 50% beta-glucans by weight!
This ensures that your dosage will be potent and effective.
If you'd like to try functional yeast extract as a nootropic, I recommend taking between 250mg-500mg daily with food!
This is the standard dose used in studies on this supplement so far.
Remember that all supplements should be taken responsibly and if you have any questions about how to take functional yeast extract as a supplement, consult your doctor.
What foods should I avoid?
If you are taking yeast extract as a supplement, make sure that you do not eat any food containing yeast!
Yeast is naturally high in beta-glucans and it may cancel out the effects of supplementation.
Yeast extract supplements typically come with this warning, but keep an eye on your diet to make sure you don't eat any food with yeast in it!
What else should I know?
There is not much known about the long-term effects of supplementation on human subjects, but there are some concerns that have been raised.
Supplements containing beta-glucans may increase blood sugar levels and interact with diabetes medications or insulin in some cases.
You should also be aware that yeast extract may affect how other medications and supplements are metabolized.
Can I stack Functional Yeast with other Nootropics?
As long as you avoid food that contains yeast, then stacking functional yeast extract with other nootropics is perfectly fine!
Functional yeast extract can provide a variety of cognitive benefits and it may enhance the effects of other supplements.
You should also be aware that there are some reports indicating beta-glucans in functional yeasts could interact with MAO-inhibitors and thyroid medications.
The effects of yeast extract may also be enhanced by stacking it with other nootropic supplements such as L-theanine and Lion's mane mushroom.
What are the side effects of yeast extract?
While there is not much known about the safety and long-term efficacy of supplementation, some studies have indicated that beta-glucans may interact with certain medications.
In theory, yeast extracts containing high concentrations of functional beta-glucan could increase blood sugar levels or alter insulin regulation in diabetics.
Additionally, yeast extract supplements could increase the risk of bleeding when taken in conjunction with blood thinners like warfarin or aspirin.
However, there is not much known about these interactions at this time!
It's still recommended that anyone taking medications seek the advice of their doctor before beginning supplementation.
So how do I get my hands on Functional Yeast Extract?
If you are interested in trying functional yeast extract as a nootropic, then your best bet is to purchase it online!
While this supplement isn't available at most brick and mortar stores yet, you can find it online (Nootropicsdepot for instance.)
If you are interested in trying this nootropic, then make sure to purchase it from reputable suppliers that clearly list the number of beta-glucans present in each dose.
Keep an eye out for supplements containing high concentrations of beta-glucans by weight to ensure you are getting a potent dosage!
Conclusion
In summary, functional yeast extract provides a variety of cognitive benefits and it is particularly effective at improving memory!
It may also enhance the effects of other nootropics or supplements you take to further boost your brainpower.
However, there are some concerns about its long-term efficacy as well as interactions with medications that should be considered before supplementation.
It's also important to note that functional yeast extract is not available in local stores, so you'll need to purchase it online if you want this nootropic!
Make sure the supplier lists the number of beta-glucans present in each dose and always consult with your doctor before starting supplementation.
In recent years, the use of Glutathione Powder as a nootropic supplement has been on the rise.
It is sold by companies such as LifeExtension and NootropicsDepot and it is often marketed for its antioxidant properties.
However, there are not many studies that have looked into whether or not this supplement actually provides any cognitive benefits to people who take it.
In this article, we will explore some of the possible reasons why taking glutathione powder could be beneficial to your brain health and what you should know about using it safely before trying it out yourself.
So without further ado, let’s look at why Glutathione could be a useful nootropic to take if you want to improve your brain function.
What is Glutathione?
Glutathione is a substance that is naturally produced within the body and it has been called “the mother of all antioxidants” as it helps with detoxification.
It also plays a role in making sure that cells are healthy, repairing DNA damage, and preventing cell death from occurring by protecting against free radicals which can cause oxidative stress on our bodies if there isn’t enough glutathione present.
Glutathione is used by the body to make sure that there are enough antioxidants available in order to fight oxidative stress, but many of us do not get optimal levels due to our lifestyles and diet choices.
This can lead to impairments in cognitive function as well as other health problems such as atherosclerosis and neurodegenerative diseases.
For this reason, many people are now taking glutathione supplements in order to increase their antioxidant levels but do it really work?
What Does the Research Say?
There is some evidence that suggests that organic forms of Glutathione (GSH) could be useful as a nootropic supplement for people who want to improve their brain function.
In a study, older adults were given either GSH or placebo for 16 weeks and results showed that those who took the glutathione performed better on cognitive function tests than those who hadn’t.
The researchers concluded by saying “Oral GSH supplementation was effective at reversing age-related cognitive decline in healthy older adults.”
In another study using animal models, it has been suggested that glutathione could be useful for improving memory and learning ability as well as protecting the brain against oxidative stress caused by neurotoxicity (which can occur when substances such as mercury bind with glutathione).
In this study, it was found that the glutathione actually restored many of the cognitive dysfunctions caused by neurotoxicity and it reduced oxidative stress in order to protect against further damage.
The researchers concluded, “These findings highlight a novel mechanism for GSH neuroprotection following [mercury] exposure and suggest that GSH preconditioning may be a promising neuroprotective strategy against neurotoxicity-mediated oxidative stress.”
In both of these studies, there was no evidence to suggest that the glutathione supplementation had any negative effects on cognition and it actually helped improve cognitive function.
What are the benefits of Glutathione?
There are many benefits associated with taking Glutathione as a nootropic supplement and these can be very useful for people who want to improve their brain function.
These include:
Helping reduces oxidative stress which has been linked to the development of neurodegenerative diseases such as Parkinson’s disease, Alzheimer’s disease, and multiple sclerosis.
Protecting against the damage caused by neurotoxicities such as mercury poisoning or other environmental toxins which could affect brain health.
Decreasing levels of homocysteine in the body, helping to reduce cardiovascular risks such as atherosclerosis and stroke which can also affect cognitive function.
Helping increase white blood cells in order to help fight infection.
Increasing the production of natural killer cells which are important for fighting off cancerous tumors and improving immune system function.
Improving mood by helping produce dopamine, serotonin, and norepinephrine in the brain can help improve cognitive functions but also affect our psychological health too.
It's worth noting that some people may experience side effects when taking glutathione. Let's take a closer look at those below.
Are There Any Negatives?
The only downside to taking glutathione for cognitive benefits is that it can cause some unpleasant side effects such as nausea, vomiting, and diarrhea.
However, this only happens in a very small percentage of people who take these supplements so it isn’t something to be overly concerned about.
In addition, there have been no studies that show that there are any negative effects on people who take glutathione for cognitive benefits.
Glutathione is an antioxidant that has many health benefits in the body and it could also be useful as a nootropic supplement, but make sure to talk to your doctor before using it yourself.
This will ensure that you know how much you should be taking and what the potential side effects may be.
If you’re interested in using glutathione as a nootropic, make sure to take the organic form and start at low dosages before building up to avoid any side effects.
You should also consider taking it with an absorption support supplement such as alpha-lipoic acid or NAC (which will improve its uptake within the body) and be sure to drink plenty of water throughout the day, especially on an empty stomach.
Glutathione's role in cognitive function
Glutathione helps to protect and regenerate neurons in the brain which can help improve cognitive function.
Glutathione protects against neurotoxicities such as mercury poisoning or other environmental toxins which can affect levels of glutathione within the body, leading to oxidative stress and impaired cognition.
It has also been shown to increase the production of natural killer cells (important for fighting off cancerous tumors) and improve immune system function to help with overall cognitive health.
People also take it for its mood-boosting properties which can affect cognitive function too.
How does glutathione work to improve cognition?
As briefly mentioned above, glutathione helps protect, regenerate and repair neurons which are important for cognitive function.
It does this by protecting the mitochondria within cells from oxidative damage caused by free radicals (by acting as an antioxidant) but also because it has been shown to strengthen neuronal membranes too.
Glutathione is not only useful in helping improve cognitive function but it can also help improve mood which in turn contributes to cognitive function.
As well as helping produce dopamine, serotonin and norepinephrine (known as the ‘happy neurotransmitters’) glutathione has been shown to increase levels of BDNF (brain-derived neurotrophic factor), an important growth hormone for neural tissue.
All in all, taking glutathione as a nootropic can be useful for protecting and repairing neurons which is important for cognitive function.
Who is Glutathione good for?
Glutathione is good for anyone who wants to improve cognitive function and protect themselves from neurotoxicity or environmental toxins.
If you’re interested in boosting mood, it may also help with that too although there are other supplements which can be used more specifically for this purpose such as Rhodiola Rosea.
Those looking to use glutathione for its antioxidant properties should know that it is not a general antioxidant and does not have the same effect as other antioxidants such as vitamin C.
It’s also good for anyone who wants to improve their immune system function which can help with cognitive health too by protecting against illnesses or infections of the brain, eyes or ears.
In particular, those with autoimmune conditions such as Lupus and Parkinson’s disease may find it particularly useful.
However, just like with any health supplement or nootropic, you should always check with your doctor before using glutathione to make sure that there are not any contraindications for use (such as current medical issues) and ensure the dosage is appropriate.
Conclusion
Glutathione is a useful supplement to use as part of your nootropic stack.
It can be particularly helpful for protecting and repairing neurons which are important for cognitive function.
It also has mood-boosting properties which contribute to cognitive function too.
You can use glutathione as a standalone supplement or combine it with other nootropics such as Rhodiola Rosea for an even greater effect on your cognition and brain health.
First off, it is a very powerful nootropic that has the ability to improve cognitive function and facilitate an increase in mental energy.
In this article, I'll be looking at 5 of the benefits of this product, so you can decide if it is right for you!
So without further ado, let's just get straight into it, shall we?
First things first, what is Sabroxy?
Sabroxy (or Oroxylum Indicum) has been used in traditional Ayurvedic medicine to treat and prevent a variety of ailments and may have neuroprotective effects.
Sabroxy® is a standardized extract comprised of the dried bark, which contains at least 10% Oroxylin A to help boost memory and support cerebral functions.
Oroxylin A is a flavone that is O-methylated from Scutellaria baicalensis and Scutellaria lateriflora plants as well as the Oroxylum Indicum tree.
Oroxylum Indicum is an Asian plant that has a long history of usage in Ayurveda.
In Ayurveda, the bark of the tree, which is high in Oroxylin A, is used to enhance the immune system and cognitive function.
Oroxylin A has been studied in several countries and has a varied profile of effects, ranging from:
Increases focus, motivation, and energy
Supports healthy inflammation levels
Provide better skin health and immune system function.
Oroxylin A has also been found to enhance CREB and BDNF, two important brain proteins that are critical for cognitive function and neurogenesis.
This study reveals that these interactions enhance NMDA signaling as well, which aids in neurogenesis.
It is also important to note that Oroxylin A has been shown to aid in the release of dopamine and acetylcholine, which are two neurotransmitters that play a key role in cognitive function.
Let's take a closer look at each benefit down below.
5. Improves cognitive function
As I mentioned previously, Sabroxy contains Oroxylin A which has been shown to increase the production of CREB and BDNF proteins in your brain.
These are two proteins that play a key role in memory formation.
A study conducted on mice found that Oroxylin A increased long-term potentiation (LTP) and memory formation in these animals.
Other studies have found that it can also aid the release of dopamine, which is important for focus and concentration during cognitive tasks.
Another study on rats with Alzheimer's Disease (AD), showed a significant improvement in cognition when compared to the control group after treatment with Oroxylin A over an extended period of time.
Memory recall, or the ability to quickly remember information that you have recently learned is another benefit of taking Sabroxy.
BDNF and CREB are proteins in your brain that are critical for proper cognitive function and neurogenesis.
In a study, Oroxylin A was shown to improve memory recall and learning ability in animals that were given a dose of the extract prior to taking part in an exercise designed for cognitive training.
Oroxylin A also improved short-term working memory as well as long-term memory formation during this process.
In addition, it was able to increase NMDA receptor activity which promotes neurogenesis.
3. It can improve your mood
In a study in mice, Oroxylin A was shown to have powerful antidepressant effects.
It was able to decrease fear and anxiety in these animals by blocking the NMDA receptor.
Similar results were found in another rat study that looked at how this extract affects depressive behaviors after traumatic brain injury (TBI).
Oroxylin A was able to reduce depressive symptoms in these animals when given before, during, and after TBI.
It also reversed the deficits in memory formation associated with brain injury and reduced anxiety levels as well.
Since many individuals who suffer from depression have underlying inflammation issues within their bodies, it is important to note that Oroxylin A has been shown to aid in healthy inflammation levels as well.
In a study, it was found that Oroxylin A reduced depressive symptoms and inhibited the release of pro-inflammatory cytokines when compared to the control group.
This shows how Oroxylin A in Sabroxy can not only improve your mood but also reduce any underlying inflammation that may be causing depressive behavior.
2. Improves skin quality
When it comes to skin health, Oroxylin A has been shown to be a powerful antioxidant that can aid in the formation of collagen and elastin as well.
In tests, it was found that this extract increased both proteins by stimulating their respective synthesis enzymes.
It also had an anti-aging effect on these animals due to its ability to suppress the release of collagenase, an enzyme that breaks down collagen in your skin.
Oroxylin A also has potent anti-inflammatory properties which can aid with redness and inflammation on various parts of your body.
But it doesn't stop there; Oroxylin A is able to penetrate into deeper layers of the dermis and can aid in diminishing wrinkles and other signs of aging.
This is because it inhibits the release of MMP-2, an enzyme that breaks down collagen.
1. Promotes immune health
Sabroxy has powerful antioxidant properties that can help aid your body in fighting off free radicals and toxins.
In a study, Oroxylin A was shown to be effective against oxidative stress from glutamate toxicity by enhancing T-cell production.
In addition to this, Oroxylin A was able to reduce the production of inflammatory cytokines such as tumor necrosis factor (TNF) and interleukin 17a (IL17A).
It also reduced levels of nitric oxide which promotes diseases such as asthma and atherosclerosis.
Oroxylin A also has anti-inflammatory properties which help to reduce the symptoms of various autoimmune diseases such as lupus, rheumatoid arthritis, and type I diabetes.
What is the most optimal Sabroxy dosage?
Sabroxy can be taken in one of two ways, either by purchasing capsules or buying the powder.
If it's your first time taking Sabroxy, I recommend taking 100mg in the morning on an empty stomach.
Beginners should start off with 100mg and work their way up from there until they find out what dosage works best for them.
You can also stack Sabroxy with other popular nootropics like; L-theanine and caffeine.
FAQ
What is Sabroxy?
Sabroxy is a standardized extract derived from the Indian trumpet tree's dried bark, which has at least 10% Oroxylin A to aid memory and neurodendritic functioning.
How do you take Sabroxy?
The best Sabroxy dosage to start off with is 100 mg taken once a day on an empty stomach. Preferably earlier in the day.
Where can I buy Sabroxy?
You can find Sabroxy in powder and capsule form on Nootropicdepot.
