Saturday, 30 November 2024

8 Safest Nootropics To Try Without Risk In 2024

safest-nootropics-to-try

In this article, I'll examine the 8 safest nootropics to try without risk. I'll cover the benefits, what you can expect from each one, and what to be aware of before trying any nootropic.

As the pace of life continues to accelerate, there is an increasing demand for solutions that can help individuals stay focused and productive in the face of ever-growing challenges.

Nootropics are a category of cognitive supplements that have been gaining traction in recent years due to their ability to improve focus, memory, and other mental abilities. A market analysis estimates that the global nootropics market size will reach USD 29.24 billion by 2028 with a compound annual growth rate (CAGR) of 15.0%.[1]

Searching for the right nootropic to try can be daunting, yet with this guide, you will discover 8 of the safest and most reliable options.

Allowing you to get started on your journey into cognitive enhancement without putting yourself at any risk.

The 8 safest nootropics to try without risk, according to scientific evidence, are:

  • Nooceptin
  • Vyvamind
  • NooCube
  • Mind Lab Pro
  • L-Theanine
  • Caffeine + L-Theanine Stack
  • Creatine
  • CDP-Choline

1. Nooceptin

With Nooceptin (also known as FDG-117), you can maximize your abilities and access heightened cognitive performance.

Nooceptin is an innovative nootropic formula that features 7 distinct ingredients designed to stimulate brain power, bolster energy levels, and inspire a steadfast clarity of thought.

Let science work its magic on you and unlock the exceptional capabilities that lay within with this nootropic blend painstakingly formulated to increase your concentration and performance.

The 7 nootropic ingredients in Nooceptin are:

  1. Citicoline (as CDP Choline aka cytidine 5'-phosphocholine, sodium)
  2. Rhodiola Rosea 150 mg Extract (3% rosavins & 1% salidroside) 
  3. Bacopa Monnieri Extract - 150 mg (40% bacosides)
  4. L-Theanine (L-γ-glutamylethylamide) - 200 mg 
  5. Ginkgo Biloba Extract - 100 mg (24% ginkgo flavone glycosides & 6% terpene lactones) 
  6. Lion's Mane Mushroom Extract - 400 mg (30% polysaccharides)
  7. Panax Ginseng Extract - 200 mg

Lion's Mane Mushroom Extract (H. erinaceus), in particular, has been shown to improve cognitive functions. One study found that taking supplements containing the fruiting body of H. erinaceus for 12 weeks significantly improved cognitive functions.[2]

Saitsu, Yuusuke, et al. conducted 3 tests: Mini-Mental State Examination (MMSE), Benton visual retention test, and Standard verbal paired-associate learning test (S-PA).

Results showed that MMSE alone demonstrated that oral intake of H. erinaceus positively affected cognitive functions, such as memory, attention, language ability, etc. 

Nooceptin Pros

  • An all-natural nootropic blend containing 7 ingredients
  • Safe and ideal for people who want to access heightened cognitive performance
  • Uses scientifically-proven ingredients that can support cognitive functions
  • You get more bang for your buck
  • No prescription needed

Nooceptin Cons

  • Not ideal for people on a tight budget

Nooceptin in Summary

Containing a blend of nootropic ingredients that work synergistically to stimulate cognitive abilities, Nooceptin is a dietary supplement that can provide substantial performance-enhancing results without any harsh side effects. It is ideal for people looking to maximize their mental performance without any risks.

2. Vyvamind

Unlock the limits of your mental prowess with Vyvamind (NSV-313) – an evidence-based nootropic blend developed from 6 powerful natural ingredients in perfect convergence.

Tap into this revolutionary cognitive enhancer and take on any challenge you face, experiencing improved clarity and focus that can last for hours giving long-term benefits extending to months.

Vyvamind contains the following nootropic ingredients:

  1. Vitamin B6 (2.5 mg)
  2. Vitamin B12 (50 mcg)
  3. L-Tyrosine (300 mg)
  4. Citicoline (CDP Choline) - 200 mg
  5. L-Theanine (150 mg)
  6. Caffeine Anhydrous (75 mg)

Caffeine stacked with L-Theanine has been shown to deliver improved cognitive performance without the annoying side effects of consuming too much caffeine.[3] The perfect recipe of the two in Vyvamind enhances their effects while reducing any jitteriness caused by caffeine on its own.

Vyvamind Pros

  • It contains 6 scientifically-proven nootropic ingredients
  • The perfect blend of L-Theanine and Caffeine for improved cognitive performance
  • No harsh side effects due to low caffeine levels
  • Ideal for long-term use
  • No prescription needed

Vyvamind Cons

  • Shipping times may take up to 2 weeks to the EU

Vyvamind in Summary

Carefully crafted to deliver maximum cognitive performance, Vyvamind is an innovative nootropic supplement that contains 6 scientifically-proven ingredients in perfect synergy. It can improve focus and clarity without any side effects, making it ideal for people looking to enhance their mental capabilities safely and naturally.

3. NooCube

NooCube is the latest innovative nootropic stack offering a range of impressive cognitive benefits. Containing 13 carefully selected nootropic ingredients, this advanced blend has been scientifically crafted to help you stay concentrated and energized throughout your day.

NooCube's nootropic ingredients are:

  1. Lutemax® 2020
  2. Bacopa Monnieri 12:1 (20% bacosides) 250 mg
  3. Huperzia Serrata (0.5% huperzine-a) 20 mg
  4. Pterostilbene 140 mcg
  5. Resveratrol 99% 14.3 mg
  6. L-Theanine 100 mg
  7. L-Tyrosine 250 mg
  8. Alpha GPC (Glycerylphosphorylcholine) 50 mg
  9. Oat Straw Extract 10:1
  10. Cat's Claw 4:1
  11. Vitamin B1 1.1 mg
  12. Vitamin B7 50 mcg
  13. Vitamin B12 2.5 mcg

Notably, Resveratrol - a polyphenol with strong antioxidant properties found in red wine and blueberries - has been added to NooCube for improved brain health.

Randomized clinical trials have conclusively shown that Resveratrol protects against oxidative stress damage[4] and is also beneficial for boosting memory recall and promoting greater cerebral blood flow - keeping your mind at its peak performance.

Noocube Pros

  • Naturally-sourced ingredients
  • Contains 13 scientifically proven nootropic ingredients
  • Added Resveratrol for improved brain health
  • No prescription needed
  • Safe and effective

Noocube Cons

  • The dosage of each ingredient could be higher

Noocube in Summary

With NooCube, you get 13 carefully selected nootropic ingredients in perfect synergy for maximum cognitive performance. It increases alertness, focus, and clarity with no harsh side effects or risk of addiction. Perfectly safe, NooCube is ideal for those looking to boost their mental capabilities without needing a prescription.

4. Mind Lab Pro

Mind Lab Pro is a nootropic stack synergistically formulated to boost the brain's full potential. Combining 11 natural ingredients, Mind Lab Pro offers unmatched cognitive enhancement without any unwanted side effects like jitters or crashes.

This premier blend includes key nootropic ingredients such as:

  1. Vitamin B6, 2,5 mg
  2. Vitamin B9, 100 mcg
  3. Vitamin B12, 7.5 mcg
  4. L-theanine, 100 mg
  5. Citicoline, 250 mg
  6. Bacopa monnieri, 150 mg
  7. Organic lion’s mane mushroom, 500 mg
  8. Phosphatidylserine, 100 mg
  9. N-acetyl L-tyrosine, 175 mg
  10. Rhodiola rosea, 50 mg
  11. Maritime pine bark extract, 75 mg

While you strive to maintain a busy lifestyle, make sure your brain is not left behind. Feed it essential nourishment like N-acetyl L-tyrosine and Vitamin B6 to keep it at its peak performance.

One study on N-acetyl L-tyrosine found that it significantly impacted cognitive performance in challenging situations. It was observed to counteract the decreased working memory and information processing resulting from demanding environmental conditions such as extreme weather or mental workload.[5]

According to Hase, Adrian et al., this effect was attributed to its ability to restore neurotransmitter catecholamine levels in the brain, which had been depleted due to these stressful conditions.

Mind Lab Pros

  • 11 natural and safe nootropic ingredients
  • Contains nootropics backed by clinical research
  • No jitters or crashes
  • No prescription needed

Mind Lab Pro Cons

  • Pricier than other blends on my list

Mind Lab Pro in Summary

Mind Lab Pro is an optimal blend of 11 natural and safe nootropic ingredients. It provides the perfect balance between effectiveness and safety, offering unmatched cognitive enhancement without any unwanted side effects like jitters or crashes. Perfectly safe, Mind Lab Pro is ideal for those looking to boost their mental capabilities without needing a prescription.

5. L-Theanine

L-Theanine (γ-glutamylethylamide) is an amino acid found naturally in green tea. It has been used for centuries as a nootropic supplement that reduces stress and improves mood.

Research has shown L-Theanine to be safe, non-toxic, and effective at improving cognitive function. It is known to increase brain serotonin, dopamine, GABA, and glycine levels to improve mental clarity and focus.[6]

Additionally, it can reduce anxiety and symptoms of depression by decreasing levels of cortisol and other stress hormones. L-Theanine works by blocking excitatory pathways in the brain while activating inhibitory pathways that help relax the mind.

L-Theanine Pros

  • Readily available in supplement form
  • L-Theanine is naturally found in green tea
  • Safe, non-toxic, and effective
  • Improves mental clarity and focus
  • Reduces anxiety and symptoms of depression

L-Theanine Cons

  • High dosages can cause drowsiness

L-Theanine in Summary

One of the most popular nootropics on the market, L-Theanine is an amino acid found naturally in green tea. It has been used for centuries to reduce stress and improve mood. Research has shown it to be safe, non-toxic, and effective at improving cognitive function. Perfectly safe for long-term use, L-Theanine is a great choice for those looking to boost their mental powers without any risks.

6. Caffeine + L-Theanine Stack

Caffeine is the most widely consumed psychoactive substance in the world. It works by blocking adenosine receptors in the brain, which causes an increase in alertness and energy levels.[7]

However, caffeine can also lead to restlessness, anxiety, jitters, and insomnia when taken in large doses or on an empty stomach.

But stacked (combined) with L-Theanine, caffeine can be a powerful nootropic supplement that can help improve focus and mental performance without unwanted side effects.

L-Theanine works synergistically with caffeine to give you an energized yet calm feeling, improving your concentration and focus while reducing any jitters or anxiety. Feel more awake without the usual side effects of stimulants.

Caffeine + L-Theanine Stack Pros

  • Energized yet calm feeling
  • Improves focus and mental performance
  • Reduces jitters and anxiety
  • Safe and non-toxic

Caffeine + L-Theanine Stack Cons

  • It can become less effective with regular use

Caffeine + L-Theanine Stack in Summary

The Caffeine and L-Theanine stack is a powerful nootropic combination that combines the stimulating effects of caffeine with the calming effects of L-Theanine. It provides an energized yet calm feeling and improves focus and mental performance without unwanted side effects like jitters or anxiety.

7. Creatine

Commonly known in the bodybuilding and fitness world, Creatine is a supplement used to improve athletic performance. But it can also be used as a nootropic for enhanced mental functions such as improved memory, learning, focus and overall brain health.[8]

Creatine works by increasing the body’s phosphocreatine stores, which helps produce ATP, a molecule that provides energy to cells. This enhances mental energy and focus. It also increases dopamine levels, which is beneficial for memory formation.[9]

It has a robust safety profile, with no serious side effects reported making it a great nootropic for people looking to improve their cognitive performance without risk.

Creatine Pros

  • Improves memory and learning
  • Enhances mental energy and focus
  • Increases dopamine levels
  • Protects neurons from damage
  • Safe and readily available in stores

Creatine Cons

  • Not ideal for people with kidney diseases

Creatine in Summary

Creatine is a well-known supplement used to improve athletic performance. But it can also be used as a nootropic to enhance mental functions such as memory, learning, focus, and overall brain health. It’s safe and readily available without any serious side effects reported making it an ideal choice for those looking to improve their cognitive performance without risk.

8. CDP-Choline

CDP-choline, commonly known as Citicoline or Cytidine 5'-diphosphocholine is a compound responsible for synthesizing the phospholipids which form cell membranes.[10]

When administered orally or directly into the bloodstream, it releases two compounds, cytidine, and choline, that play an important role in cellular structure maintenance. It is known to increase dopamine and acetylcholine levels (ACh) in the brain, which helps with focus, attention span, and learning.

CDP-choline is well-tolerated and non-toxic, making it a safe option without risk.

CDP-Choline Pros

  • Improves focus and attention span
  • Increases dopamine and ACh levels
  • Protects neurons from damage
  • Safe and readily available

CDP-Choline Cons

  • Not as effective as other nootropics on this list

CDP-Choline in Summary

CDP-Choline is an important source of nutrients for cell maintenance and enhances cognitive functions such as focus and attention span. It is safe and readily available without any serious side effects reported making it an ideal choice for those looking to improve their cognitive performance without risk.

What Are the Best Safest Nootropics To Try Without Risk?

safest nootropics to try

According to my market research, user reviews, and scientific studies, these are the 8 safest nootropics to try without risk:

  1. Nooceptin
  2. Vyvamind
  3. NooCube
  4. Mind Lab Pro
  5. L-Theanine
  6. Caffeine + L-Theanine Stack
  7. Creatine
  8. CDP-Choline

All the nootropics on my list have been scientifically tested and proven safe and effective, so you can confidently try them without fear. However, it is always important to consult your healthcare professional before taking any of these supplements.

You can enhance your cognitive capabilities without any adverse side effects by leveraging the safest nootropics on this list. Whether you want to improve focus, boost memory, or become more productive, these nootropics will help you reach your goals without risk.

I want to make sure your journey in cognitive enhancement is safe and efficient, which is why I've only included natural nootropics that have been used by thousands of people worldwide - including myself.

With these nootropics, you can improve your mental performance without compromising safety or wasting money.

How to Choose the Safest Nootropics?

When it comes to choosing the safest nootropics, certain criteria need to be considered:

  • Safety: This one is obvious. Firstly, ensure your chosen nootropic has a proven safety profile and is free from any side effects based on the available scientific literature.
  • Potency: Secondly, make sure the nootropic is potent enough to provide noticeable results. That means looking at the doses and dosages recommended by experts (especially if you choose nootropic blends).
  • Availability: Lastly, the nootropic should be easy to obtain through online stores or local supplement shops. This way, you’ll always have access whenever you need it.

These are the 3 main criteria to consider when choosing the safest nootropics.

If you have any kidney diseases, it is highly recommended that you speak with your healthcare professional before following my advice.

What Are the Benefits of the Safest Nootropics?

By taking the safest nootropics, you can:

  • Improve cognitive performance
  • Boost focus and attention span
  • Enhance memory recall and learning capacity
  • Increase energy levels naturally
  • Reduce stress and anxiety levels

These benefits can be experienced without any adverse side effects, making these nootropics a safe and effective solution for improving mental performance.

It's worth pointing out that all of the nootropics on my list are only natural, so they're free from any harsh chemicals that can lead to side effects.

This makes any nootropics on this list great for long-term use and can be combined/stacked for better results.

What Are the Side Effects of the Safest Nootropics?

The side effects of the safest nootropics are minimal. For example, some users have reported feeling headaches and dizziness when taking caffeine-based nootropic blends like Vyvamind.

Stacking two or more nootropics can also increase side effects, so it’s important to stick to recommended dosages and not exceed them. However, given the nature of these natural nootropics, the side effects are rare, usually mild, and don’t last long.

The bottom line is that all of these nootropics have been tested thoroughly and proven to be safe when taken as directed. So, if you follow the recommended dosages and guidelines, you should not experience serious side effects.

Do the Safest Nootropics Without Risk Really Work?

So do I personally think that the safest nootropics without risk really work?

In short, yes. I have personally used many of these nootropics and can confirm that they do have a noticeable effect on your cognitive performance.

The key is finding a balanced approach to combining them in order to maximize their efficacy while minimizing potential side effects. With some experimentation, you can find the perfect nootropic stack for your needs.

If you don't want to experiment too much or find the world of nootropics a bit overwhelming, I highly recommend looking into nootropic blends like Nooceptin.

With Nooceptin, you can be confident that it contains the right dose of safe and effective nootropics, making it a great option for those who want to get started without worrying about potential side effects.

You also get more bang for your buck compared to buying individual nootropics.

Final Thoughts

So what do we know about the safest nootropics to try without risk?

Firstly, they must have a proven safety profile with minimal side effects. Secondly, they must be potent enough to provide noticeable results. Thirdly, they should be easy to obtain online or in local supplement shops.

Lastly, the scientific literature should be able to back up their efficacy.

We know that natural nootropics are more favorable than synthetic ones due to their lower risk of side effects. We also know that you can stack more than one nootropic for better results, but it is important to stick to recommended dosages.

Nootropic blends like Nooceptin are the best value for money as they contain the right dosage of safe and effective nootropics, making them a great option for those who want to get started without worrying about potential side effects.

I hope this article has given you an insight into which are the safest nootropics to try without risk; if you have any questions, please feel free to reach out to me privately.

Thank you for reading!

John

References
  1. Nootropics market size & share analysis report, 2028. Nootropics Market Size & Share Analysis Report, 2028. (n.d.). Retrieved February 13, 2023, from https://www.grandviewresearch.com/industry-analysis/nootropics-market 
  2. Saitsu, Yuusuke et al. “Improvement of cognitive functions by oral intake of Hericium erinaceus.” Biomedical research (Tokyo, Japan) vol. 40,4 (2019): 125-131. doi:10.2220/biomedres.40.125
  3. Owen, Gail N et al. “The combined effects of L-theanine and caffeine on cognitive performance and mood.” Nutritional neuroscience vol. 11,4 (2008): 193-8. doi:10.1179/147683008X301513
  4. Cicero, Arrigo F G et al. “Resveratrol and cognitive decline: a clinician perspective.” Archives of medical science : AMS vol. 15,4 (2019): 936-943. doi:10.5114/aoms.2019.85463
  5. Hase, Adrian et al. “Behavioral and cognitive effects of tyrosine intake in healthy human adults.” Pharmacology, biochemistry, and behavior vol. 133 (2015): 1-6. doi:10.1016/j.pbb.2015.03.008
  6. Baba, Yoshitake et al. “Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study.” Journal of medicinal food vol. 24,4 (2021): 333-341. doi:10.1089/jmf.2020.4803
  7. Daly, John W et al. “The role of adenosine receptors in the central action of caffeine.” Pharmacopsychoecologia vol. 7,2 (1994): 201-213.
  8. Roschel, Hamilton et al. “Creatine Supplementation and Brain Health.” Nutrients vol. 13,2 586. 10 Feb. 2021, doi:10.3390/nu13020586
  9. Andres, R H et al. “Effects of creatine treatment on the survival of dopaminergic neurons in cultured fetal ventral mesencephalic tissue.” Neuroscience vol. 133,3 (2005): 701-13. doi:10.1016/j.neuroscience.2005.03.004
  10. Secades, J J, and G Frontera. “CDP-choline: pharmacological and clinical review.” Methods and findings in experimental and clinical pharmacology vol. 17 Suppl B (1995): 1-54.


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Thursday, 28 November 2024

Neuroprotective and Antidepressant Effects of Oleamide

Oleamide

Oleamide is a naturally occurring chemical that has been studied for its neuroprotective and antidepressant effects.

It is also known as an endocannabinoid, which means it can bind to the same receptors in the brain that are targeted by marijuana.

Oleamide was discovered when scientists were doing research on oleic acid metabolism in rats.

They found that one of the metabolites they had created, called oleamide, had some interesting properties.

In this article, we're going to talk about what oleamide is, its effects on the brain and body.

We'll also look at some potential uses for this compound as a nootropic supplement. So without further ado, let's get started.

What is Oleamide?

Oleamide is a chemical that is derived from oleic acid.

It was first discovered in the blood of humans and animals as an endogenous compound, which means it occurs naturally within your body.

Oleamide works by binding to cannabinoid receptors CB1 and CB2, just like other cannabinoids such as tetrahydrocannabinol (THC) and THCV.

Oleamide is considered an endocannabinoid because it can produce effects similar to cannabinoids found in the cannabis plant, without causing any mind-altering or intoxicating effects at all.

It's metabolized by enzymes that are part of your body's innate immune system called fatty acid amide hydrolase (FAAH).

In addition to binding cannabinoid receptors in your brain, oleamide also binds serotonin and dopamine receptors.

This action has been found to help regulate other neurotransmitters, such as glutamate and GABA (gamma-aminobutyric acid).

Oleamide is able to bind all of these receptors because it has a similar structure to the endogenous cannabinoids that your body produces, called anandamide and arachidonoylethanolamine (AEA).

Oleamide's Effects on the Body and Brain

Oleamide

In a study looking at oleamide's effects on rats, scientists found that it increased their appetite.

They also saw an increase in locomotor behavior when they injected oleamide into rats' brains.

This is believed to be caused by its ability to bind to CB1-receptors in the hypothalamus, which is responsible for regulating locomotor behavior.

Oleamide also has neuroprotective effects.

It binds to adenosine A-type receptor sites and GABA C receptor sites both of which are known to be involved with mood regulation and stress response.

This helps protect your brain cells from damage, which is why it has been studied as a potential treatment for neurodegenerative diseases.

Oleamide also acts as an antidepressant in mice by binding to serotonin receptors and increasing the synthesis of serotonin.

It's currently being investigated for its therapeutic effects on human depression.

As you can see, oleamide has many interesting effects on the brain and body.

What is Oleamide Used For?

Oleamide has recently gained a lot of interest as a potential treatment for neurodegenerative diseases.

It has been studied in animal models of Alzheimer's Disease, Parkinson's Disease, and Huntington's disease to help protect brain cells from damage caused by these conditions.

Oleamide has also shown some promise as an antidepressant drug.

This is because it binds serotonin receptors and helps increase serotonin production in the brain.

It's also been shown to bind dopamine receptors, which may contribute to its antidepressant effects as well.

This is also why it has become popular among biohackers looking for a nootropic supplement to improve their mood and motivation.

Oleamide is often combined with choline sources like Alpha GPC or Citicoline because its neuroprotective effects depend on an adequate supply of acetylcholine in your brain.

Biohackers also experiment with stacking oleamide together with other supplements like L-theanine, ashwagandha, or curcumin to help improve their focus and mood.

Some people have also found that taking oleamide together with a low dose of THC can produce interesting effects as well.

The combination has been called "the Entourage effect", which refers to the idea that cannabinoids work better together than they do alone.

This is because oleamide helps increase the permeability of cannabinoid receptors in your blood-brain barrier, which allows THC to cross into your brain more easily.

What are the benefits?

As briefly mentioned above, the benefits of Oleamide, when used as a Nootropic, are:

  • Protection of brain cells from damage
  • Helps regulate neurotransmitters such as serotonin, dopamine, and GABA
  • May act as an antidepressant in humans
  • Helps regulate mood and behavior

The benefits of Oleamide are well-established in the scientific literature.

However, there are also some potential side effects of taking oleamide as a nootropic supplement.

Let's take a closer look at those below.

What are the side effects?

Oleamide has been shown to have some side effects in clinical trials.

Some of these include headaches, nausea, and vomiting, stomach aches or pain, dizziness, or drowsiness.

However, it's important to note that oleamide is still being studied for its therapeutic potentials so there could be more negative side effects yet to be discovered.

That being said, most people don't experience any side effects when taking oleamide as a nootropic supplement.

What's the optimal dosage?

In terms of dosage, most studies have used a dose of around 200mg to 800mg per day for oleamide's nootropic effects.

It's important to note that the optimal dosage of Oleamide in a nootropic stack will depend on your goals and how it affects you personally.

People react differently to supplements, so it might be best for you to start with a low dose and work yourself up from there if necessary.

What I like about Oleamide

I like Oleamide for a number of reasons.

First, I have personally experienced the antidepressant effects of oleamide firsthand and found it to be quite effective in helping regulate my mood when dealing with anxiety or depression.

Second, oleamide is very well-tolerated by most people who take it as a nootropic supplement.

This makes it easier to experiment with different dosages and find what works best for you, without worrying about negative side effects.

Finally, oleamide seems to work synergistically with other nootropics like Alpha GPC or L-theanine, which means you can stack it together with these supplements for enhanced cognitive effects.

What I don't like about Oleamide

However, there are also some potential side effects of taking oleamide as a nootropic supplement.

Some of these include headaches, nausea, and vomiting, stomach aches or pain, dizziness, or drowsiness.

It's also unclear how oleamide works in our body at the molecular level to produce its beneficial effects on brain health and neurotransmitter regulation.

There are anecdotal reports online that taking Oleamide can cause a "strange" feeling in your body.

Some people have also reported negative effects such as jitters or irritability, which can be quite unpleasant if you don't take the right dosage for your individual needs.

Personally, I have only experienced drowsiness which can be quite annoying if you need to be alert and focused on a task.

In Summary

Oleamide is a natural nootropic supplement that has been shown to have neuroprotective and antidepressant effects in clinical trials.

It also doesn't seem to cause negative side effects when taken at the right dosage for your needs.

Luckily, Oleamide is very well-tolerated by most people who take it as a nootropic supplement.

This makes it easier to experiment with different dosages and find what works best for you, without worrying about negative side effects.

However, there are also some potential side effects of taking oleamide as a nootropic supplement.

Some of these include headaches, nausea, and vomiting, stomach aches or pain, dizziness, or drowsiness.



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Wednesday, 27 November 2024

8 Most Powerful Nootropics In 2024

the-most-powerful-nootropics

In this article, I'll look at the 8 most powerful nootropics. I'll also cover the potential risks and side effects you may run into and the benefits you can expect.

Nootropics come in all shapes and sizes, and it can be challenging to determine which one is best for you. The market is full of options, and it can sometimes be difficult to know which will work best.

Today I'll be discussing the 8 most powerful nootropics available in 2023. These have a proven track record and are backed by research, so you can be sure they'll provide the results you're looking for.

Let's see what Science says about these 8 brain boosters, shall we?

The most powerful nootropics, according to scientific evidence, are:

  • Nooceptin
  • Modafinil
  • Armodafinil
  • Phenibut
  • Piracetam
  • Noopept
  • L-Theanine + Caffeine
  • CDP-Choline

1. Nooceptin

Nooceptin (FDG-117) is a powerful nootropic blend scientifically developed to help unlock your full mental capacity. Its amazing formula contains 7 carefully selected nootropic ingredients designed to provide energy and clarity of mind.

These ingredients work synergistically to improve focus and performance, allowing you to maximize your potential.

Nooceptin contains the following nootropic ingredients:

  1. Citicoline (as CDP Choline aka cytidine 5'-phosphocholine, sodium)
  2. Rhodiola Rosea 150 mg Extract (3% rosavins & 1% salidroside) 
  3. Bacopa Monnieri Extract - 150 mg (40% bacosides)
  4. L-Theanine (L-γ-glutamylethylamide) - 200 mg 
  5. Ginkgo Biloba Extract - 100 mg (24% ginkgo flavone glycosides & 6% terpene lactones) 
  6. Lion's Mane Mushroom Extract - 400 mg (30% polysaccharides)
  7. Panax Ginseng Extract - 200 mg

With the synergistic combination of Ginkgo Biloba, L-Theanine, Citicoline, and Rhodiola Rosea, you can unleash peak performance in all aspects of your life.

This powerful stack not only boosts mental alertness but also offers protection from stress, increasing concentration capabilities and improving cognitive abilities for maximum focus.

Rhodiola Rosea, in particular, has been shown to increase cognitive function, memory, attention span, and reduce stress.[1]

Nooceptin Pros

  • An all-natural blend containing 7 nootropics
  • Increases mental alertness and cognitive abilities
  • Protects from stress Improves memory, attention span, and focus
  • You don't need a prescription from your doctor

Nooceptin Cons

  • Shipping times can take up to 2 weeks

Nooceptin in Summary

Nooceptin is a nootropic blend, meaning it contains several different ingredients that have been scientifically tested and proven to help increase your focus, mental alertness, and cognitive abilities. This powerful combination of 7 nootropics will give you the energy and clarity of mind to reach peak performance in all aspects of your life.

2. Modafinil

Modafinil (Provigil) is a eugeroic (wakefulness-promoting) nootropic used to treat excessive sleepiness caused by narcolepsy, shift work disorder, and obstructive sleep apnea.

It is one of the most popular nootropics on the market as it has a long history of clinical use for treating excessive daytime fatigue in patients with narcolepsy.[2]

Modafinil has been found to remarkably affect the human brain, boosting dopamine levels far beyond what is considered clinically relevant. Remarkably, it does this by occupying and blocking the same binding site for cocaine in the striatum - an important area associated with reward motivation.[3]

While the precise mechanism of Modafinil is yet to be elucidated, Volkow, Nora D et al. suggest that it may act on certain areas in our brain related to hypocretin, histamine, epinephrine, γ-aminobutyric acid (GABA), and glutamate.

Modafinil Pros

  • Increases wakefulness and alertness
  • Improves cognitive abilities and focus
  • Reduces fatigue
  • One of the most powerful nootropics currently on the market

Modafinil Cons

  • You need a prescription from your doctor

Modafinil in Summary

Considered one of the most powerful nootropics currently on the market, Modafinil is a wakefulness-promoting drug widely used to treat narcolepsy and shift work disorders. It is known for increasing alertness and cognitive abilities and reducing fatigue. While it does require a prescription from your doctor, Modafinil can be a great choice for those looking to take their cognitive performance to the next level.

3. Armodafinil

Armodafinil (Nuvigil) is a newer version of Modafinil and shares many of the same benefits. It is slightly more powerful than Modafinil and has been found to have longer-lasting effects.

Armodafinil is the longer-acting isomer of Modafinil and is used to treat obstructive sleep apnea, narcolepsy, and shift work disorder. Compared with Modafinil, Armodafinil maintains higher plasma concentrations later in the day in healthy subjects.[4]

If you're looking for a powerful nootropic lasting up to 15 hours, then Armodafinil should be your go-to choice.

Armodafinil Pros

  • Longer lasting effects than Modafinil
  • Increases wakefulness and alertness
  • Improves cognitive abilities and focus
  • Reduces fatigue

Armodafinil Cons

  • Requires a prescription from your doctor

Armodafinil in Summary

Armodafinil is the newer and more powerful version of Modafinil. It maintains higher plasma concentrations later in the day and lasts up to 15 hours. Like its predecessor, Armodafinil increases wakefulness, alertness, cognitive abilities, and focus while reducing fatigue.

4. Phenibut

Phenibut (beta-phenyl-gamma-aminobutyric acid HCl) is an amazing neuropsychotropic drug that was discovered and first used in Russia during the 1960s.

Not only does it have anxiolytic properties, but it also increases cognition by mimicking GABA receptors of both types A and B.[5] Phenibut is considered a tranquilizer and nootropic drug and is widely used to ease anxiety, improve sleep quality, and reduce stress.

More recently, Phenibut has gained popularity among people with social anxiety and is often used to promote feelings of well-being. The downside of Phenibut is that it can be addictive and cause withdrawals in people who take it for too long.

That said, Phenibut is one of the most powerful nootropics on the market and can be a great choice for those looking to reduce anxiety and improve cognition.

Phenibut Pros

  • Anxiolytic properties
  • Improves sleep quality and cognitive abilities
  • Reduces stress levels
  • Promotes feelings of well-being

Phenibut Cons

  • It can be addictive with overuse
  • Tolerance can develop quickly with regular use

Phenibut in Summary

Phenibut is an amazing neuropsychotropic drug that has gained popularity among people with social anxiety. It is a tranquilizer and nootropic drug used to ease anxiety, improve sleep quality, reduce stress levels, and promote feelings of well-being. Despite its many benefits, Phenibut can be addictive and cause withdrawal when taken for too long. Therefore, using this nootropic wisely and taking breaks during long-term use is important.

5. Piracetam

Piracetam (2-oxo-1-pyrrolidine-acetamide) is one of the most widely used nootropic drugs and holds tremendous promise for optimizing brain function.

It's a cyclic derivative of gamma-aminobutyric acid, which increases learning abilities, memory retention capacity, and overall metabolism in cerebral activity.

Studies have demonstrated that Piracetam can modify the physical attributes of plasma membranes by making them more liquid and safeguarding cells from hypoxia (low levels of oxygen in body tissues).[6]

Piracetam is a versatile nootropic compound possessing antithrombotic, neuroprotective, and rheological properties. Restoring membrane fluidity through its interaction with phospholipids in the membranes of cells is highly efficacious for various disorders, from dementia and vertigo to myoclonus and stroke.

Piracetam Pros

  • Improves learning abilities and memory retention capacity
  • Reduces hypoxia
  • Modifies physical attributes of plasma membranes
  • Antithrombotic, neuroprotective, and rheological properties

Piracetam Cons

  • It can be difficult to obtain because it is unregulated in many countries

Piracetam in Summary

Piracetam is one of the most widely used nootropics and holds tremendous promise for optimizing brain function. It increases learning abilities, memory retention capacity, and overall metabolism in cerebral activity.

6. Noopept

Noopept (GVS-111), a proline-containing dipeptide, has both nootropic and neuroprotective properties. This remarkable compound can stimulate inhibitory interneurons in the hippocampus stratum radiatum, which is the area of the brain responsible for learning and memory.[7]

Noopept has shown remarkable potential in protecting the brain from various damaging forces, such as ionic disruption, excessive excitation of nerve cells, free radical formation, and pro-inflammatory cytokine accumulation.[8]

Its ability to prevent neurotrophin deficits - which are common features of neurological diseases like Alzheimer's Disease (AD) – has led researchers to investigate its neuroprotective action in various studies.

Noopept is a powerful ally in the fight against cognitive decline and numerous neurological diseases.

Noopept Pros

  • Stimulates inhibitory interneurons in the hippocampus stratum radiatum
  • Protects the brain from various damaging forces
  • Prevents neurotrophin deficits common to neurological diseases like Alzheimer’s Disease

Noopept Cons

  • More long-term studies are needed to understand the risks of long-term use

Noopept in Summary

Noopept is a proline-containing dipeptide with nootropic and neuroprotective properties. It can stimulate inhibitory interneurons in the hippocampus stratum radiatum, a brain area responsible for learning and memory. It has demonstrated the potential to protect the brain from various damaging forces.

7. L-Theanine + Caffeine

L-Theanine and Caffeine are two natural nootropic ingredients that, on their own, have powerful cognitive benefits. But when combined, they form a powerful duo that can improve mental performance, focus, alertness, energy levels and promote relaxation and well-being.

L-Theanine is an amino acid found in green tea that has been shown to reduce stress, relaxation, anxiety, and sleep quality.[9] It can also reduce the stimulating effects of caffeine, improving its overall efficacy.

Caffeine is a powerful stimulant that increases alertness and concentration; it has been used for centuries to improve cognitive performance. Caffeine also enhances memory, mood, reaction time, and decision-making skills.

One study aimed to compare the effects of 50 mg of caffeine with and without 100 mg of L-theanine on cognition and mood in healthy volunteers.[10]

The cognitive abilities tested included word recognition, rapid visual information processing, critical flicker fusion threshold, and attention switching. The mood was also assessed. 27 participants were tested at baseline and again 60 min and 90 min after each treatment (separated by a 7-day washout).

The results showed that caffeine improved subjective alertness at the 60 min mark and accuracy on the attention-switching task at 90 min.

Furthermore, the combination of L-theanine and caffeine improved both speed and accuracy of performance for the attention-switching task at 60 min. It also reduced susceptibility to distracting information in the memory task at both 60 min and 90 min marks.

This research indicates that when L-theanine and caffeine are combined, cognitive performance is heightened significantly, while distraction during memory tasks becomes a thing of the past.

These outcomes mirror other studies, demonstrating that combining these two nootropic ingredients can be highly advantageous for excelling in activities requiring intense mental focus.

L-Theanine + Caffeine Pros

  • An all-natural nootropic stack widely available in stores
  • Improves mental performance, focus, alertness, and energy levels
  • Reduces stress, relaxation, anxiety, and sleep quality

L-Theanine + Caffeine Cons

  • L-Theanine can cause drowsiness in high dosages

L-Theanine + Caffeine in Summary

L-Theanine and caffeine are two natural nootropics that have powerful cognitive benefits when used together. They can heighten mental performance, focus, alertness, and energy levels while reducing stress levels and promoting relaxation.

8. CDP-Choline

CDP-choline (cytidine-5'-diphosphocholine) is a phospholipid clinically proven to aid in treating cognitive disorders. It works by restoring and preserving brain cell membranes, thus allowing for improved mental health and performance.

It is a nootropic supplement that has been used to optimize cognitive performance by enhancing neurotransmission in the brain. It works by increasing the synthesis of acetylcholine (ACh), which is essential for many cognitive functions such as memory and learning.

CDP-choline acts on the Alpha7 nicotinic receptor, a type of receptor found in neurons throughout the brain, enabling improved communication between neurons. This can lead to faster and more efficient processing of information in the brain.[11]

According to Knott, Verner et al., CDP-choline can modulate brain waves and neural oscillations associated with cognitive processes through EEG (electroencephalography) recordings.

The EEG recordings have revealed that CDP-choline can induce dose-dependent changes in delta and alpha oscillations in healthy volunteers given both low (500 mg) and moderate (1000 mg) doses of CDP-choline when compared to placebo.

This effect is thought to be driven by increased cholinergic transmission resulting from increased acetylcholine synthesis with CDP-choline administration. 

This makes CDP-choline a powerful nootropic if you're looking to optimize brain function and cognition.

CDP-Choline Pros

  • Can help treat cognitive disorders
  • Enhances neurotransmission in the brain
  • Increases acetylcholine synthesis for improved cognition

CDP-Choline Cons

  • Not as potent as other nootropics like Nooceptin and Modafinil

CDP-Choline in Summary

CDP-choline is a powerful nootropic compound clinically proven to aid cognition and brain function. It works by increasing acetylcholine synthesis, an essential neurotransmitter for many cognitive functions such as memory and learning.

What Are The Most Powerful Nootropics?

the most powerful nootropics

According to my market research, clinical trials, and user reviews, the 8 most powerful nootropics are:

  1. Nooceptin
  2. Modafinil
  3. Armodafinil
  4. Phenibut
  5. Piracetam
  6. Noopept
  7. L-Theanine + Caffeine
  8. CDP-Choline

My list contains a mix of natural and pharmaceutical compounds that have been tested for their cognitive enhancement capabilities.

All of these nootropics can be used to improve mental performance, focus, alertness, and energy levels while reducing stress levels and promoting relaxation.

If you're brand spanking new to the world of nootropic supplements, I highly recommend looking into nootropic blends like Nooceptin. With Nooceptin you get 7 all-natural nootropic ingredients that have been clinically tested and proven effective for cognitive enhancement.

It's a great starting point for anyone looking to experience the power of nootropics without having to take multiple supplements.

How to Choose The Most Powerful Nootropics?

When choosing which nootropic to take, it’s important to do your research and consider the pros and cons of each. Consider your goals for using a nootropic, as different types will be better suited for certain tasks.

Also, read up on reviews from other people who have used the product in question and the manufacturer’s instructions on how to safely use the nootropic. Your health should always be a priority, so ensure you read up on potential side effects before taking a new supplement.

There's a big difference between synthetic and natural nootropics, and it's important to be aware of the pros and cons of each type. Synthetics tend to be more effective but can also have more side effects than natural nootropics.

What Are the Benefits of The Most Powerful Nootropics?

The benefits of using some of the most powerful nootropics on the market are numerous. They range from improved mental performance, focus, and alertness to reduced stress levels and cognitive enhancement.

Synthetic nootropics such as Phenibut and Modafinil are some of the best for improving your productivity while providing you with long-term benefits such as better memory formation, learning speed, and increased relaxation.

Natural nootropics such as Nooceptin and L-Theanine + Caffeine are some of the healthiest alternatives as they are derived from natural sources and lack the harsh side effects often associated with synthetics.

When you use nootropic blends like Nooceptin you get the added bonus of having multiple nootropic ingredients working synergistically, meaning that they can provide greater benefits than a single nootropic.

What Are the Side Effects of The Most Powerful Nootropics?

The side effects come from various factors, including the type of nootropic you’re taking, your body chemistry, and pre-existing medical conditions.

That being said, some common side effects associated with the most powerful nootropics include headaches, nausea, and dizziness. Modafinil and Phenibut can cause more serious side effects. Phenibut can cause severe withdrawals when used in high doses, so it’s important to discuss with your doctor how much is safe for you.

Modafinil has been associated with a rare skin condition called Stevens-Johnson Syndrome. It’s important to pay attention to any changes in your skin after taking Modafinil and discuss them with your doctor.

Do The Most Powerful Nootropics Really Work?

So do these powerful nootropics on my list really work? The answer is yes.

These nootropics have been clinically tested and proven to provide cognitive enhancement, focus, alertness, improved mental performance, and energy levels while reducing stress and promoting relaxation.

Synthetics may be more effective, but they come with the risk of possible side effects, so it’s important to discuss with your doctor which type of nootropic would be best for you.

Natural nootropics are safer and have fewer risks, so they’re great for beginners or people who are more sensitive to the effects of synthetic nootropics.

Final Thoughts

So what do we know about the most powerful nootropics?

We know they can help improve mental performance, focus, alertness, and cognitive function while reducing stress levels. Some synthetic nootropics can be more effective than natural nootropics but come with the risk of side effects.

We also know that nootropic blends like Nooceptin can provide greater benefits than a single nootropic on its own. This is because different ingredients work together synergistically, meaning that they can provide more efficient and greater results.

So if you're looking for a powerful ally to help you stay sharp and focused, the most powerful nootropics are definitely worth considering!

References
  1. Ivanova Stojcheva, Emilija, and José Carlos Quintela. “The Effectiveness of Rhodiola rosea L. Preparations in Alleviating Various Aspects of Life-Stress Symptoms and Stress-Induced Conditions-Encouraging Clinical Evidence.” Molecules (Basel, Switzerland) vol. 27,12 3902. 17 Jun. 2022, doi:10.3390/molecules27123902
  2. da Silva Behrens, Nilce Sanny Costa et al. “Experience with the use of modafinil in the treatment of narcolepsy in a outpatient facility specialized in diurnal excessive sleepiness in São Paulo.” Sleep science (Sao Paulo, Brazil) vol. 7,1 (2014): 65-8. doi:10.1016/j.slsci.2014.07.017
  3. Volkow, Nora D et al. “Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications.” JAMA vol. 301,11 (2009): 1148-54. doi:10.1001/jama.2009.351
  4. Darwish, Mona et al. “Armodafinil and modafinil have substantially different pharmacokinetic profiles despite having the same terminal half-lives: analysis of data from three randomized, single-dose, pharmacokinetic studies.” Clinical drug investigation vol. 29,9 (2009): 613-23. doi:10.2165/11315280-000000000-00000
  5. Lapin, I. “Phenibut (beta-phenyl-GABA): a tranquilizer and nootropic drug.” CNS drug reviews vol. 7,4 (2001): 471-81. doi:10.1111/j.1527-3458.2001.tb00211.x
  6. Winnicka, Katarzyna et al. “Piracetam--an old drug with novel properties?.” Acta poloniae pharmaceutica vol. 62,5 (2005): 405-9.
  7. Kondratenko, Rodion V et al. “Effect of nootropic dipeptide noopept on CA1 pyramidal neurons involves α7AChRs on interneurons in hippocampal slices from rat.” Neuroscience letters vol. 790 (2022): 136898. doi:10.1016/j.neulet.2022.136898
  8. Ostrovskaya, Rita U et al. “Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation.” Journal of biomedical science vol. 21,1 74. 6 Aug. 2014, doi:10.1186/s12929-014-0074-2
  9. Hidese, Shinsuke et al. “Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.” Nutrients vol. 11,10 2362. 3 Oct. 2019, doi:10.3390/nu11102362
  10. Owen, Gail N et al. “The combined effects of L-theanine and caffeine on cognitive performance and mood.” Nutritional neuroscience vol. 11,4 (2008): 193-8. doi:10.1179/147683008X301513
  11. Knott, Verner et al. “Effects of acute CDP-choline treatment on resting state brain oscillations in healthy volunteers.” Neuroscience letters vol. 591 (2015): 121-125. doi:10.1016/j.neulet.2015.02.032


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