If you're looking for a way to increase your mental focus, there are two common amino acids that offer different benefits.
L-Tyrosine is the precursor to dopamine and norepinephrine, which can help improve moods and support cognitive function.
L-Theanine helps promote alpha brain waves, which are associated with relaxation.
So which one should you take? Let's find out!
L-Tyrosine Overview
L-Tyrosine is an amino acid that is used by the body to produce dopamine, norepinephrine, and epinephrine.
These neurotransmitters are responsible for mood regulation as well as cognitive function.
When your levels of these neurotransmitters drop, it can lead to depression and anxiety disorders.
By supplementing with L-tyrosine you can support your mood and cognitive function.
L-Tyrosine works by helping to maintain healthy levels of neurotransmitters.
When your body is under stress, it releases catecholamines such as dopamine and norepinephrine in order to help you deal with the situation.
However, when these chemicals are released too often or not enough they can start to cause damage over time.
This will allow your body to continue functioning as it should without experiencing mood swings or cognitive impairment that is common with low dopamine and norepinephrine levels.
L-Theanine Overview
L-theanine is a natural amino acid that is commonly found in green tea. It has been shown to promote alpha brain waves, which are associated with relaxation.
It does this by crossing the blood-brain barrier where it then binds itself to glutamate receptors in the brain.
This reduces the number of stress hormones in your body while promoting relaxation.
The result is a reduction of anxiety and an increase in mental focus.
People take L-theanine for a variety of reasons including:
To support relaxation and reduce anxiety.
Reduce stress by promoting alpha brain waves.
Maintain healthy neurotransmitter levels within the body, which will help improve moods and cognitive function over time.
L-theanine has also become increasingly popular in the nootropic community where it is typically taken in conjunction (stacked) with caffeine.
This combination provides an increased level of focus and attention without increasing anxiety levels and jitters, which can occur when using caffeine by itself.
For this reason, it's a great idea to start with l-theanine and see what your results are like before moving on to more expensive options such as tyrosine supplements.
So Which is Better For Increasing Mental Focus?
L-theanine is one of the most potent nootropics when it comes to increasing mental focus.
However, L-tyrosine is supposed to be the king of increasing mental focus.
So which one's better?
It depends.
L-theanine may be your best choice for certain situations, like highly-demanding work.
On the other hand, L-tyrosine may be your best choice for other situations, like when you need to focus on creative or memory tasks.
I always recommend starting out with L-theanine.
If you find that it doesn't work well with you, then consider trying L-tyrosine.
This way, you save money because you're not paying for two expensive supplements when one will do.
L-theanine also tends to be much more tolerable than L-tyrosine for most people first starting out.
I frequently encounter inquiries about the intricate aspects of dietary supplements, especially those linked to brain health and cognitive function. Two substances that often come up in these discussions are CDP Choline (Citicoline) and Alpha-GPC, both popular supplements in the nootropic community.
CDP Choline, also known as Citicoline, is a naturally occurring compound found in every cell of our body. It's an essential intermediary in the synthesis of phosphatidylcholine, a major component of the brain's grey matter. On the other hand, Alpha-GPC (Alpha-glycerophosphocholine) is a cholinergic compound that is considered to have cognitive-promoting properties and is believed to support cellular membranes.
Choline, the common factor between these two compounds, plays a crucial role in human health. It's an essential nutrient, vital for a variety of physiological functions, including cell structure integrity, cell messaging, fat transport, and metabolism, DNA synthesis, and most importantly, brain and nervous system function.
While both CDP Choline and Alpha-GPC are significant sources of choline, they differ in several key areas, including their mechanisms of action, metabolic pathways, bioavailability, potential health benefits, and side effects. We will delve into these differences throughout this discussion.
Let's take a closer look below.
Understanding Choline and Its Role in the Human Body
Structurally, choline is a quaternary ammonium salt that consists of a nitrogenous base, a hydroxyl group, and three methyl groups. It is categorized as a water-soluble, essential nutrient and is the precursor molecule for the neurotransmitter acetylcholine.
Acetylcholine (ACh), synthesized from choline, is crucial for many functions including muscle control, mood regulation, memory, and other central and peripheral nervous system responses. Choline's role in neurotransmitter synthesis underscores its importance in maintaining optimal cognitive function.
Choline deficiency, although uncommon, can have significant health implications. It can lead to liver dysfunction, muscle damage, and neurological disorders. More subtly, it can contribute to cognitive impairment, including memory and learning deficits, making it essential in diets for both physical and cognitive health.
As we progress, I'll further illustrate the differences between the two prominent choline supplements, CDP Choline and Alpha-GPC, to better inform your nootropic decisions.
In-Depth Look at CDP Choline (Citicoline) as a Nootropic
As mentioned above, CDP Choline, or Citicoline, is a compound that naturally occurs in the body. Its molecular structure consists of cytidine and choline, joined together by a diphosphate bridge. As a nootropic supplement, it provides a potent source of choline and supports the synthesis of important phospholipids, including phosphatidylcholine.
When ingested, CDP Choline is broken down in the intestines into cytidine and choline. These components are then absorbed separately and recombined in the brain, creating citicoline again. Citicoline then donates choline for acetylcholine synthesis and cytidine for RNA and DNA synthesis, supporting brain function and health.
Nootropic benefits associated with CDP Choline include enhanced memory, improved focus, and better overall cognitive function. It's been studied for its potential therapeutic benefits in conditions like Alzheimer's disease, stroke, and glaucoma. Additionally, it has been indicated to support neural repair and reduce inflammation in the brain.[1]
CDP Choline is generally well tolerated, but like any supplement, potential side effects may occur. These can include headaches, nausea, diarrhea, and other gastrointestinal issues. Always consult a healthcare provider before starting any new supplement, especially if you are currently on other medications or have pre-existing health conditions.
Detailed Examination of Alpha-GPC as a Nootropic
Alpha-GPC (Alpha-glycerophosphocholine) is a naturally occurring compound that provides a potent source of choline. Its molecular structure consists of a glycerophosphate molecule bound to a choline molecule, allowing for effective penetration of the blood-brain barrier (BBB).
After ingestion, Alpha-GPC is quickly absorbed in the intestines and transported to the brain where it readily gives up its choline for the synthesis of acetylcholine. The remaining glycerophosphate can be used in the synthesis of phosphatidylcholine, a major component of cell membranes.
The nootropic benefits associated with Alpha-GPC are primarily related to cognitive enhancement and neuroprotection. It's been suggested to improve memory, thinking skills, and learning. It's also been explored in the treatment of Alzheimer's disease, dementia, and stroke, and has potential benefits in physical performance and recovery.[2]
Alpha-GPC is generally considered safe but may occasionally cause side effects like headaches, fatigue, nervousness, nausea, diarrhea, and low blood pressure. As with any supplement, it's essential to consult with a healthcare provider before beginning a regimen, particularly if you have existing health conditions or are on other medications.
Comparative Analysis of CDP Choline (Citicoline) & Alpha-GPC
Both CDP Choline and Alpha-GPC exhibit high bioavailability and efficient absorption. Alpha-GPC, however, has been found to increase serum choline levels more rapidly due to its quicker absorption from the gastrointestinal tract and ready passage across the blood-brain barrier.
While both supplements undergo metabolic pathways that contribute choline to the acetylcholine synthesis process, they do so differently. CDP Choline is hydrolyzed into cytidine and choline before being recombined in the brain. Alpha-GPC directly supplies choline, with the remaining glycerophosphate molecule contributing to phospholipid synthesis.
Both nootropic supplements have demonstrated potential for cognitive enhancement and neuroprotection, although their applications may differ. CDP Choline has been explored more thoroughly in neural repair post-stroke and in treating glaucoma. Alpha-GPC has shown promise in Alzheimer's treatment and enhancing cognitive function in healthy adults, and potentially improving physical performance.
Both compounds are generally well-tolerated, with potential side effects often being mild and gastrointestinal in nature. Alpha-GPC, however, may lower blood pressure, a consideration for those with hypotension.
The standard dosages for these nootropic compounds can vary widely depending on individual needs, the specific cognitive benefits being sought, and the overall health and lifestyle of the user.
For CDP Choline (Citicoline), the typical nootropic dose ranges are as follows:
For cognitive enhancement in generally healthy individuals: 250-500 mg per day
For therapeutic usages, such as in the treatment of memory impairments or cognitive decline: 1000-2000 mg per day
Alpha-GPC tends to have slightly lower typical dosage ranges:
For cognitive enhancement in healthy individuals: 300-600 mg per day
For therapeutic usages, such as in addressing cognitive decline or enhancing physical performance: 600-1200 mg per day
Again, it's important to emphasize that these are general guidelines and the optimal dosage can vary widely between individuals. Some people may find lower doses to be effective, while others may require higher doses for the same effects.
Additionally, as with any supplement, both of these compounds should be started at the lower end of the dosage range to assess tolerance and effect, with gradual increases as needed and tolerated.
Medical Uses and Potential Therapeutic Applications
Choline supplementation can be beneficial in a variety of conditions, including neurodegenerative diseases, stroke recovery, certain liver diseases, and conditions related to choline deficiency. It is also often used for general cognitive enhancement.[3]
In medical treatment, CDP Choline has been applied in stroke recovery, reducing the risk of further brain damage and enhancing neural repair. Its potential benefits in treating glaucoma and Parkinson's disease have also been explored.[4]
A recent study aimed to evaluate the effectiveness of Alpha-GPC (Choline alphoscerate) in treating cognitive impairments in patients suffering from adult-onset neurological disorders. Despite its long history, there have been discrepancies in the global medical community regarding its authorization and discussions about its effectiveness.[5]
The research involved a comprehensive analysis of relevant studies sourced from PubMed, Web of Science, and Embase. The criteria for consideration included studies evaluating the effects of Alpha-GPC, either alone or combined with other compounds, on adult-onset cognitive impairment. The studies must report on cognition, function, and behavior. The selected studies were then assessed for risk of bias using the Cochrane risk of bias tool.
After meticulous screening of 1,326 studies and 300 full-text articles, the researchers included seven randomized controlled trials (RCTs) and one prospective cohort study in their analysis. The results pointed to significant positive effects of Alpha-GPC. Specifically, when combined with donepezil, it showed significant improvements in cognition, functional outcomes, and behavioral outcomes.
Furthermore, patients who received Alpha-GPC demonstrated significantly better cognition than those who received either a placebo or other medications. The mean difference (MD) in cognitive scores was reported at 3.50, with a 95% confidence interval (CI) of 0.36 to 6.63.
In conclusion, the study presents strong evidence suggesting that Alpha-GPC, either alone or combined with donepezil, improves cognition, behavior, and functional outcomes among patients with neurological conditions associated with cerebrovascular injury.
My Final Thoughts on Alpha-GPC and CDP-Choline
As we wrap up this discussion on Alpha-GPC and CDP Choline (Citicoline), it's important to acknowledge that both these choline-containing compounds have distinct strengths that can serve specific needs in the field of cognitive enhancement and neuroprotection.
Both compounds show promise in supporting cognitive health, enhancing memory, and offering neuroprotective benefits. They act as crucial sources of choline and participate in essential metabolic pathways, impacting brain health and function in notable ways. Whether used for general cognitive enhancement or as part of a therapeutic strategy for neurodegenerative conditions, both Alpha-GPC and CDP Choline have scientific backing that underscores their potential.
However, remember that while they have similarities, they also have key differences. Alpha-GPC is rapidly absorbed, increasing serum choline levels swiftly and has shown promise in cognitive enhancement in healthy adults and Alzheimer's treatment. CDP Choline, on the other hand, has a unique metabolic pathway and has been extensively studied for its potential in stroke recovery and glaucoma treatment.
In my personal exploration and understanding of cognitive enhancers, I've found both Alpha-GPC and CDP Choline (Citicoline) to be effective and unique in their own ways.
Alpha-GPC, with its swift absorption and marked influence on serum choline levels, has shown promise not only in my day-to-day cognitive enhancement but also in scientific studies relating to Alzheimer's treatment.
On the other hand, CDP Choline, with its distinct metabolic pathway, has been an interesting component of my health regimen. My personal experience aligns with research suggesting its potential in supporting brain health, particularly in areas like stroke recovery.
However, I should stress that individual experiences can vary greatly due to our unique biochemistry. As always, consult with a healthcare provider before starting any new supplement regimen.
All in all, Alpha-GPC and CDP Choline both offer compelling benefits. Choosing between the two, or considering a combination, depends largely on individual health goals, tolerance, and medical history. My journey continues to evolve as I learn more about these fascinating compounds and their effects on cognitive health.
L-Theanine, often known as Theanine, is a glutamic acid analog that can be found in tea (particularly green tea) and the basidiomycete fungus Boletus badius and guayusa.
This chemical is most commonly known as L-theanine, which refers to the L-amino acid.
Theanine is an analog to glutamine and glutamate. It is carried into the intestinal brush-border membrane via a Na(+)-dependent cotransport in the small intestine.
Free L-theanine in the circulation can then pass through the blood-brain barrier after absorption.
L-Theanine helps you relax, get a good night's sleep, and focus. It also works well with caffeine.
Furthermore, those who take Theanine have greater alpha wave activity, the alertness that occurs when you are not yet stressed but still attentive.
The effects of L-theanine parallel those of GABA neurotransmission, which regulates a delicate balance between activation and inhibition.
These inhibitory signals are vital for mood, memory, attention, and relaxation in our cognitive framework.
Green or black tea has approximately 20 mg L-theanine per cup, whereas a 200 mg dose is used in most research.
The Japanese have conducted a large number of clinical trials to demonstrate that Theanine is both effective and safe.
As early as 1964, Japan authorized Theanine as a completely safe supplement, allowing for unrestricted dosages in all meals except those for newborns.
L-theanine is able to pass the blood-brain barrier, as previously said.
Theanine has psychoactive effects, such as promoting mental and physical relaxation while also enhancing cognitive function and mood.
The mechanism of action of L-theanine is to raise inhibitory neurotransmitter levels as well as work immediately to block the production of excitatory neurotransmitters which leads to neuroprotection and relaxation.
L-theanine is an analog of glutamate, a neurotransmitter. Excess glutamate may be neurotoxic and cause cell death, contributing to the cognitive losses seen in dementia and stroke patients.
L-theanine's neuroprotective effects are two-fold. L-theanine resembles glutamate in its chemical makeup, allowing it to compete with glutamate for postsynaptic receptors and inhibiting its binding.
L-theanine binds to the glutamate transporter as well, preventing uptake and limiting available glutamate levels.
Theanine also affects the glutamine (Gln) transporter and suppresses the conversion of Gln to glutamate by glutaminase, which in turn prevents neurons from taking up extracellular Gln.
This mechanism contributes to L-theanine's neuroprotective properties in stressed cells.
The primary action of L-Theanine is to boost the entire brain inhibitory neurotransmitter GABA. It also increases brain dopamine levels and has a low affinity for AMPA, kainate, and NMDA receptors.
L-Theanine can be taken orally, and it has antioxidant, anti-inflammatory, and neuroprotective actions.
L-Theanine acts as a glutamate receptor antagonist and inhibits cortical neuron excitation by inhibiting the activity of glutamatergic neurotransmission pathways.
Alpha-band Oscillatory Brain Activity
The alpha-band (8-14 Hz) is a relaxed, yet alert state. Researchers examined variations in alpha-band activity during a demanding attention effort where participants ingested either 250 mg L-theanine or placebo using EGs.
L-theanine increased attention-related alpha-band signals in the brains of those who received it. Furthermore, the topographical analysis revealed greater activity in the right hemispheric posterior parietal cortex.
These findings support a strong psychoactive effect of L-theanine, especially on visual attention.
L-Theanine activates the Alpha wave in the brain, an awake, alert, and calm physical and mental state is attained that demonstrates Theanine's value in stress management.
Inhibitory Neurotransmitter Glycine
Glycine is a neurotransmitter that has GABA-like effects. An L-theanine supplement can quickly boost glycine levels in the brain.
The release of dopamine within the striatum, a region of the telencephalon that receives input from the cortex to control behavior, is aided by glycine.
Elevated glycine is thought to cause the beneficial effects of L-theanine, such as its ability to soothing.
Certain mood-regulating benefits and balance in neurotransmission are attributed directly to increased glycine.
Immune System Effects
Human gamma-delta T cells are a type of T cell that is part of the first line of defense against germs and malignancies. Certain short-chain alkylamines can activate human gamma-delta T cells.
The personalized monoclonal antibodies raised against the antigens specific to the GD2 protein in OSNs and APCs are able to stimulate gamma-delta T cells.
L-theanine, an amino acid found only in tea beverages that is broken down to ethylamine, is the most important dietary source of alkylamines.
The supplementation with L-theanine and catechins-enriched capsules has recently been reported to reduce the incidence of cold and flu symptoms while improving gamma-delta T cell function.
A four-week trial, published in 2003, included 11 coffee drinkers and 10 tea drinkers who drank 600 milliliters of coffee or black tea every day.
The production of antibacterial proteins was up to five times higher in tea drinkers, suggesting a stronger immune response, according to blood sample analysis.
Circulatory System Effects
Tea (Camellia sinensis) has been found to increase vascular function and decrease the risk of heart disease.
Endothelial nitric oxide is a key regulator of endothelial functions.
In a study, L-theanine's effects on NO production and vasodilation were investigated in response to ERK/eNOS activation in vitro.
The findings of our studies suggest that tea's l-theanine-mediated vascular health advantages may be attributed to its ERK/eNOS signaling activity.
A lot of people are looking for ways to increase dopamine in the brain, but is Alpha GPC the answer? Does it increase dopamine levels in the brain?
Alpha GPC is a form of choline that has powerful cognitive effects. It helps to transport choline to the brain and boosts the production of acetylcholine, as well as dopamine, calcium, and cell membrane phospholipids.
Alpha GPC will improve dopamine levels, which can help with mood and brain function.
In this article, I'll take a closer look at the Alpha GPC effects on dopamine.
So without further ado, let's just get straight into it, shall we?
How Alpha-GPC Affects Dopamine in The Brain
Alpha-GPC is a choline compound that increases the brain's synthesis of acetylcholine, an important neurotransmitter.
It also facilitates the release and uptake of other key neurotransmitters such as dopamine, serotonin, and norepinephrine.
This helps to boost attention span and mental focus, improve memory formation and recall capacity, increase motivation and drive, increase the ability to learn complex tasks, and more.
Alpha-GPC plays a role in the reward circuits of the brain.
It has been shown to increase dopamine levels independent of whether it is injected, ingested orally, or combined with other supplements such as caffeine and L-theanine (found naturally in green tea).
By increasing catecholamine activity within neurons that release these neurotransmitters, Alpha-GPC can enhance mood and decrease feelings of stress.
Alpha-GPC is also known to have neuroprotective properties on brain cells by blocking NMDA receptors in the hippocampus region, which protects neurons from glutamate toxicity.
Why Dopamine is Important
Dopamine is responsible for our survival.
It plays a prominent role in the brain’s limbic system, which controls emotions and behavior including motivation, pleasure-seeking behaviors (such as eating), moods, sexual behavior, and feelings of well-being.
Dopamine is important in the brain’s reward pathway, which reinforces behaviors that ensure our survival and reproduction.
The dopamine pathways associated with motivation have been called the “seeking circuit.”
If a rat can turn on this seeking system by pressing a lever or pulling a chain to get food pellets, it will keep pressing the lever again and again – to the exclusion of all other activities.
Dopamine is a neurotransmitter that serves as a chemical messenger between neurons, or nerve cells in the brain.
It helps control the movement of muscles throughout our body, from breathing to heart rate and digestion.
Dopamine also helps us feel pleasure and motivates many behaviors that are necessary for our survival as human beings.
Our brains naturally release dopamine when we eat or have sex – reinforcing these activities through feelings of satisfaction and motivation for more.
COMT is an enzyme that breaks down dopamine, norepinephrine, and epinephrine.
By inhibiting COMT, Alpha-GPC prevents the breakdown of these neurotransmitters thus increasing their levels in the brain for improved cognitive function.
Alpha-GPC boosts dopamine levels through reuptake inhibition.
Dopamine then binds to its receptors on the postsynaptic neuron to elicit its effect.
By inhibiting reuptake, Alpha-GPC allows for more dopamine binding and thus increases the effects of dopamine on neurons in different parts of your brain for improved cognitive function.
A key point is that Alpha-GPC boosts dopamine levels while not decreasing extracellular concentrations of dopamine like methylphenidate (Ritalin) does.
This is an important distinction because the decreased extracellular dopamine concentrations caused by Ritalin results in the desensitization of dopamine receptors.
The increased levels of dopamine induced by Alpha-GPC do not cause this problem and, thus, allow for improved cognitive function throughout your entire day without the need to take breaks (cycle on and off).
Alpha-GPC Boosts Dopamine Levels in The Prefrontal Cortex
The prefrontal cortex is responsible for controlling memory, attention, thought processes, and decision making.
It is also important for inhibiting impulsivity and aggression.
Dopamine plays a critical role in the prefrontal cortex, as it can signal to other parts of your brain that you’re ready to take action (ie: stop what you’re doing and do something else).
As dopamine declines with age, so does cognitive ability. Alpha-GPC is the best way to boost dopamine in this area of your brain.
A study from 2017 found that administration of Alpha GPC increased levels of acetylcholine and improved cognitive performance, particularly working memory tasks.
In addition, it also boosted dopamine levels when compared to a placebo.
In this article, I'll take a closer at the 8 best nootropics for dementia. I'll also cover the potential risks and side effects you may run into and the benefits you can expect.
Dementia is one of the most feared diseases in the world. It can rob you of your memories, your independence, and even your life.
While there is no cure for dementia, there are some medications and supplements that can help slow its progression.
In this article, I will take a look at 8 of the best nootropics for dementia.
So without further ado, let's dive in, shall we?
The best nootropics for dementia, according to scientific evidence, are:
Mind Lab Pro
Ginkgo Biloba
Rhodiola Rosea
Bacopa Monnieri
Noopept
Piracetam
Aniracetam
Oxiracetam
1. Mind Lab Pro
Mind Lab Pro is a nootropic supplement that contains 11 different cognitive-enhancing ingredients. One of these ingredients, citicoline, has been shown to be a promising nootropic for improving cognitive impairment such as vascular dementia.[1]
Citicoline works by increasing acetylcholine (ACh) levels in the brain. Acetylcholine is a neurotransmitter that plays an important role in memory and learning. Citicoline also provides the building blocks for phospholipids, which are essential for neuronal function and cell membranes.[2]
Mind Lab Pro also contains adaptogens like Rhodiola Rosea and Ashwagandha, which can help reduce stress and improve cognitive function.[3]
Mind Lab Pros
11 nootropic ingredients work together to support cognitive function
Protects the brain from age-related damage
Mind Lab Cons
Can be a bit pricey
Not available in stores
Mind Lab Pro in Summary
Mind Lab Pro is an excellent nootropic supplement for those with dementia or cognitive impairment. It contains ingredients that can help increase ACh levels, protect the brain from damage, and reduce stress.
2. Ginkgo Biloba
Ginkgo Biloba is a popular herbal remedy that has been used for centuries to treat a variety of ailments. More recently, it has been studied for its cognitive-enhancing effects.
It is thought to work by improving blood circulation and reducing inflammation in the brain. This can help protect nerve cells and improve communication between them, leading to improved cognitive function.
One study found that Ginkgo Biloba Extract is effective in people with dementia at 200mg/day for at least 5 months.[4]
Ginkgo Biloba Pros
It can improve blood circulation and reduce inflammation in the brain
It helps protect nerve cells and improve communication between them
Ginkgo Biloba Cons
It may not be effective for everyone
May interact with other medications (such as blood thinners)
Gingko Biloba in Summary
Gingko Biloba is an effective nootropic for dementia. It can help improve blood circulation, reduce inflammation, and protect nerve cells. However, it may not work for everyone and may interact with other medications.
3. Rhodiola Rosea
Rhodiola Rosea is an adaptogenic herb that has been used for centuries to treat various conditions.
Rhodiola Rosea has been shown to improve cognitive function in animal models of dementia and Parkinson's disease. The mechanisms by which it does this are not fully understood but may involve reducing inflammation and oxidative stress and increasing levels of key neuroprotective factors.
Additionally, Rhodiola Rosea has been shown to activate the PI3K/Akt pathway, a key regulator of cell survival and synaptic function. This may help protect neurons from damage caused by Aβ peptides and other pathogenic factors associated with Alzheimer's disease and dementia.[5]
Wang, Hualong et al. also found that salidroside, which is the active compound in Rhodiola Rosea, protects neurons against Aβ-induced neurotoxicity. It was also shown to improve locomotor activity in the APP/PS1 mice. Salidroside exerts its protective effects by activating the PI3K/Akt targets of the mTOR cell signaling pathway.[6]
Rhodiola Rosea Pros
Shown to improve cognitive function in animal models of dementia and Parkinson's disease
Reduces inflammation and oxidative stress
Activates the PI3K/Akt pathway
Rhodiola Rosea Cons
Most of the data on Rhodiola Rosea's efficacy is from animal studies
Rhodiola Rosea in Summary
Rhodiola Rosea is an adaptogenic herb that has shown promise in treating dementia and cognitive impairment. It works by reducing inflammation and oxidative stress, increasing levels of key neuroprotective factors and activating the PI3K/Akt pathway, a key regulator of cell survival and synaptic function.
4. Bacopa Monnieri
Bacopa Monnieri, also known as Brahmi, is a plant that has been used for centuries in Ayurvedic medicine to treat various conditions.
More recently, it has been studied for its cognitive-enhancing effects. Bacopa Monnieri is thought to work by increasing levels of the neurotransmitters acetylcholine (ACh) and serotonin[7] which are involved in memory and learning.
According to a double-blind, randomized, placebo control study, Brahmi significantly affected memory retention. Specifically, it seemed to decrease the rate of forgetting newly acquired information.
The study also found that Brahmi had no effect on other areas of memory, such as attention, verbal and visual short-term memory, and the retrieval of pre-experimental knowledge.[8]
Thus, Bacopa Monnieri may be effective at improving memory retention in people with cognitive impairment diseases such as Alzheimer's disease and dementia.
Bacopa Monnieri Pros
Significantly affects memory retention
Decreases the rate of forgetting newly acquired information
Bacopa Monnieri Cons
May not be effective at improving other areas of memory
Bacopa Monnieri in Summary
The plant Bacopa Monnieri has been used for centuries in Ayurvedic medicine to treat various conditions such as cognitive impairment. It is thought to work by increasing levels of the neurotransmitters acetylcholine (ACh) and serotonin, which are involved in memory and learning.
5. Noopept
Noopept is a cognitive enhancer that was specifically designed as a dipeptide analog of the standard cognition enhancer, piracetam.
According to one study, Noopept was shown to prevent ionic disbalance, excitotoxicity, free radicals, pro-inflammatory cytokines accumulation, and neurotrophin deficit typical for different kinds of brain damage.[9]
The study provides evidence that novel cognitive enhancer noopept protects PC12 cells against deleterious actions of Aβ through inhibiting oxidative damage and calcium overload and suppressing the mitochondrial apoptotic pathway.
According to Ostrovskaya et al., the neuroprotective properties of Noopept likely include its ability to decrease tau phosphorylation[10] and restore the altered morphology of PC12 cells.[11]
Noopept Pros
Inhibits oxidative damage and calcium overload
Suppresses the mitochondrial apoptotic pathway
It helps to decrease tau phosphorylation
Restores altered morphology of PC12 cells
Noopept Cons
Need more research to support its efficacy
Noopept in Summary
The cognitive enhancer Noopept was specifically designed as a dipeptide analog of the standard cognition enhancer, piracetam. It is thought to work by preventing ionic disbalance, excitotoxicity, free radicals, pro-inflammatory cytokines accumulation, and neurotrophin deficit typical for different kinds of brain damage.
6. Piracetam
Piracetam is a neurotransmitter gamma-aminobutyric acid (GABA) derivative, which modulates neurotransmission in various transmitter systems.
It has neuroprotective and anticonvulsant properties, and improves neuroplasticity. At a vascular level, it appears to reduce erythrocyte adhesion to vascular endothelium, hinder vasospasm, and facilitate microcirculation.[12]
This diverse range of physiological effects contributes to Piracetam's beneficial effects on cognitive impairment, such as dementia and other neurological disorders.
Piracetam Pros
It has neuroprotective and anticonvulsant properties
Improves neuroplasticity
Reduces erythrocyte adhesion to vascular endothelium
Hinders vasospasm
Facilitates microcirculation
Piracetam Cons
It's hard to get your hands on in some countries
Piracetam in Summary
Piracetam is a derivative of the neurotransmitter gamma-aminobutyric acid (GABA) that has various physiological effects, including restoring cell membrane fluidity. It has neuroprotective and anticonvulsant properties, and improves neuroplasticity. It is used in various clinical indications, including cognitive disorders and dementia.
7. Aniracetam
Aniracetam is a pyrrolidone derivative and cognition enhancer that has been shown to reverse memory deficits in several studies of dementia.
It increases the production of acetylcholine, a neurotransmitter involved in memory and learning.[13] Aniracetam also has anti-inflammatory and antioxidant properties, which may help to protect the brain from damage caused by age-related inflammation and oxidative stress.[14]
According to one study, Aniracetam was shown to improve cognitive function in elderly patients with mild to moderate cognitive impairment.[15] The study found that Aniracetam improved psychobehavioural parameters in patients with dementia.
Aniracetam Pros
It increases the production of acetylcholine
It has anti-inflammatory and antioxidant properties
It improves cognitive function in elderly patients with mild to moderate cognitive impairment
Aniracetam Cons
Can be hard to get your hands on in some countries
Oxiracetam is a racetam drug that is used for cognitive enhancement. It is believed to work by increasing cholinergic and glutamatergic neurotransmission.
This increases communication efficiency between neurons, leading to improved learning and memory. Oxiracetam has also been found to protect neurons from damage, which may explain its usefulness in treating dementia.
One study found that Oxiracetam was efficacious in treating dementia, with significant improvements seen in neuropsychological test scores and quality of life ratings.[16]
According to the study, Oxiracetam showed a statistically significant improvement in the neuropsychological battery and the quality of life scale compared to placebo. The drug was generally well tolerated.
Oxiracetam Pros
Works by increasing cholinergic and glutamatergic neurotransmission
It has been found to protect neurons from damage
It was found to be efficacious in treating dementia in one study
Oxiracetam Cons
More studies are needed to confirm its efficacy
Not all online vendors sell it
Oxiracetam in Summary
Oxiracetam is a cognitive enhancer that is used to improve learning and memory. It is believed to protect neurons from damage, making it useful in treating dementia.
What Are the Best Nootropics for Dementia?
The best nootropics for dementia are those that increase levels of acetylcholine and serotonin in the brain. Nootropics that protect neurons from damage are also thought to be useful in treating dementia.
The best nootropics for dementia are:
Mind Lab Pro
Ginkgo Biloba
Rhodiola Rosea
Bacopa Monnieri
Noopept
Piracetam
Aniracetam
Oxiracetam
My recommendation for the best nootropic for dementia is Mind Lab Pro. It is a natural nootropic blend that contains 11 cognitive-enhancing ingredients. Mind Lab Pro improves overall cognitive function making it a great supplement for those suffering from cognitive impairment.
How to Choose the Right Nootropic Supplement for Dementia?
When choosing a nootropic supplement for dementia, it is important to choose one that has been clinically tested and shown to be effective.
Natural adaptogens have the most evidence regarding cognitive enhancement and dementia. Therefore, I recommend choosing a nootropic supplement that contains natural adaptogens such as Bacopa Monnieri, Rhodiola Rosea, and Ginkgo Biloba.
It's also important to choose a supplement that is made by a reputable company, and that contains high-quality ingredients, so you don't end up wasting your money on a poor-quality product.
What Are the Benefits of Nootropics for Dementia?
Nootropics offer several benefits for those suffering from dementia.
Nootropics that increase levels of acetylcholine and serotonin in the brain can improve cognitive function and help to reduce symptoms of dementia.
Nootropics that protect neurons from damage are also thought to be useful in treating dementia, as they can help slow the disease's progression.
Overall, the benefits of nootropics for dementia include:
Improved cognitive function
Reduced symptoms of dementia
Slowed progression of the disease
If you want to improve your cognitive function and reduce your risk of dementia, then nootropics may be an excellent option.
What Are the Side Effects of Nootropics for Dementia?
Nootropics are generally well-tolerated and have few side effects.
The most common side effects of nootropics for dementia are mild and include:
Headache
Nausea
Anxiety
Insomnia
Dizziness
It's worth noting that the side effects differ from synthetic nootropics to natural nootropics.
Natural nootropics such as Mind Lab Pro are generally considered to be much safer than synthetic nootropics such as Piracetam, as they don't come with the same risks.
If you experience any severe side effects while taking nootropics for dementia, stop taking the supplement and speak to a doctor.
Do Nootropics Really Work for Dementia?
According to science and the available evidence, nootropics can effectively be used as supplements for dementia.
Specifically, nootropics that work to increase levels of acetylcholine and serotonin in the brain and protect neurons from damage are the most effective in treating dementia symptoms.
That being said, dementia is a complex disease, and no supplement will cure it. However, nootropics can help improve cognitive function, slow the progression of the disease, and improve quality of life.
Final Thoughts
If you're looking for a way to improve your cognitive function and reduce your risk of dementia, then nootropics may be a good option for you.
When choosing a nootropic supplement, it's important to choose one that contains natural adaptogens and is made by a reputable company.
Overall, nootropics offer several benefits for those suffering from dementia, including improved cognitive function, reduced symptoms, slowed disease progression, and improved quality of life.
Hemmings, Brian A, and David F Restuccia. “PI3K-PKB/Akt pathway.” Cold Spring Harbor perspectives in biology vol. 4,9 a011189. 1 Sep. 2012, doi:10.1101/cshperspect.a011189
Roodenrys, Steven et al. “Chronic effects of Brahmi (Bacopa monnieri) on human memory.” Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology vol. 27,2 (2002): 279-81. doi:10.1016/S0893-133X(01)00419-5
